The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Dendrimer-Encapsulated Camptothecins: Increased Solubility, Cellular Uptake, and Cellular Retention Affords Enhanced Anticancer Activity In vitro
Abstract
A biocompatible polyester dendrimer composed of the natural metabolites, glycerol and succinic acid, is described for the encapsulation of the antitumor camptothecins, 10-hydroxycamptothecin and 7-butyl-10-aminocamptothecin. The cytotoxicity of the dendrimer-drug complex toward four different human cancer cell lines [human breast adenocarcinoma (MCF-7), colorectal adenocarcinoma (HT-29), non–small cell lung carcinoma (NCI-H460), and glioblastoma (SF-268)] is also reported, and low nmol/L IC50 values are measured. Cellular uptake and efflux measurements in MCF-7 cells show an increase of 16-fold for cellular uptake and an increase in drug retention within the cell when using the dendrimer vehicle. (Cancer Res 2006; 66(24): 11913-21)
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Nanoparticles in Medicine: Therapeutic Applications and Developments
Zhang, L., Gu, F., Chan, J., Wang, A., Langer, R., & Farokhzad, O. (2008) · Clinical Pharmacology & Therapeutics · doi:10.1038/sj.clpt.6100400 · Cited by 2,657
Advanced targeted therapies in cancer: Drug nanocarriers, the future of chemotherapy
Pérez-Herrero, E., & Fernández-Medarde, A. (2015) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2015.03.018 · Cited by 1,875
Gold nanoparticle platforms as drug and biomacromolecule delivery systems
Duncan, B., Kim, C., & Rotello, V. M. (2010) · Journal of Controlled Release · doi:10.1016/j.jconrel.2010.06.004 · Cited by 469
Polymeric nanoparticles for targeted treatment in oncology: current insights
Joshi, M. D., Patravale, V., & Prabhu, R. (2015) · International Journal of Nanomedicine · doi:10.2147/ijn.s56932 · Cited by 438
Dendrimers: A versatile nanocarrier for drug delivery and targeting
Sherje, A. P., Jadhav, M., Dravyakar, B. R., & Kadam, D. (2018) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2018.07.030 · Cited by 373
Metadata
- Authors
- Morgan, M. T., Nakanishi, Y., Kroll, D. J., Griset, A. P., Carnahan, M. A., Wathier, M., Oberlies, N. H., Manikumar, G., Wani, M. C., & Grinstaff, M. W.
- Venue
- Cancer Research
- Published
- 2006-12-15
- Volume
- 66
- Issue
- 24
- Pages
- 11913-11921
- ISSN
- 0008-5472 (ISSN-L)
- 1538-7445
- OpenAlex
- W2123557591
- Cited by
- 301
- References
- 35
- FWCI
- 8.32
- Type
- journal article
- Language
- en
- Open access
- closed
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- Morgan, M. T., Nakanishi, Y., Kroll, D. J., Griset, A. P., Carnahan, M. A., Wathier, M., Oberlies, N. H., Manikumar, G., Wani, M. C., & Grinstaff, M. W. (2006). Dendrimer-Encapsulated Camptothecins: Increased Solubility, Cellular Uptake, and Cellular Retention Affords Enhanced Anticancer Activity In vitro. Cancer Research. https://doi.org/10.1158/0008-5472.can-06-2066
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