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GRP78 Induction in Cancer: Therapeutic and Prognostic Implications
Abstract
Cancer cells adapt to chronic stress in the tumor microenvironment by inducing the expression of GRP78/BiP, a major endoplasmic reticulum chaperone with Ca2+-binding and antiapoptotic properties. GRP78 promotes tumor proliferation, survival, metastasis, and resistance to a wide variety of therapies. Thus, GRP78 expression may serve as a biomarker for tumor behavior and treatment response. Combination therapy suppressing GRP78 expression may represent a novel approach toward eradication of residual tumors. Furthermore, the recent discovery of GRP78 on the cell surface of cancer cells but not in normal tissues suggests that targeted therapy against cancer via surface GRP78 may be feasible. [Cancer Res 2007;67(8):3496–9]
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Cited by
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Endoplasmic reticulum stress signals in the tumour and its microenvironment
Chen, X., & Cubillos-Ruiz, J. R. (2021) · Nature Reviews Cancer · doi:10.1038/s41568-020-00312-2 · Cited by 1,356
Targeting the unfolded protein response in disease
Hetz, C., Chevet, E., & Harding, H. P. (2013) · Nature Reviews Drug Discovery · doi:10.1038/nrd3976 · Cited by 910
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Urra, H., Dufey, E., Avril, T., Chevet, E., & Hetz, C. (2016) · Trends in Cancer · doi:10.1016/j.trecan.2016.03.007 · Cited by 615
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Self-citation
Metadata
- Authors
- Lee, A. S.
- Venue
- Cancer Research
- Published
- 2007-04-15
- Volume
- 67
- Issue
- 8
- Pages
- 3496-3499
- ISSN
- 0008-5472 (ISSN-L)
- 1538-7445
- OpenAlex
- W2084276537
- Cited by
- 856
- References
- 0
- FWCI
- 19.21
- Type
- journal article
- Language
- en
- Open access
- closed
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