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Identification of Let-7–Regulated Oncofetal Genes
Open accessAbstract
MicroRNAs (miRNA) are small RNA molecules of ∼20 to 22 nucleotides that reduce expression of proteins through mRNA degradation and/or translational silencing. Each known miRNA has a large number of predicted targets. Members of the let-7/miR-98 family of miRNAs are up-regulated at the end of embryonic development. Let-7 is often down-regulated early during cancer development, suggesting that let-7–regulated oncofetal genes (LOG) may become reexpressed in cancer cells. Using comparative bioinformatics, we have identified 12 conserved LOGs that include HMGA2 and IMP-1/CRD-BP. IMP-1 has growth-promoting activities through stabilization of c-myc mRNA. We experimentally confirmed that IMP-1 is a direct let-7 target that promotes cell growth and motility of tumor cells, and we confirmed by proteomics analysis that IMP-1 and HMGA2 are major miRNA targets. Our data suggest that a substantial part of the growth inhibitory activities of let-7 comes from suppressing the expression of IMP-1. LOGs could be novel therapeutic targets and potential biomarkers for cancer treatment. [Cancer Res 2008;68(8):2587–91]
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Cited by
Widespread changes in protein synthesis induced by microRNAs
Selbach, M., Schwanhäusser, B., Thierfelder, N., Fang, Z., Khanin, R., & Rajewsky, N. (2008) · Nature · doi:10.1038/nature07228 · Cited by 3,429
Transcriptome-wide Identification of RNA-Binding Protein and MicroRNA Target Sites by PAR-CLIP
Hafner, M., Landthaler, M., Burger, L., Khorshid, M., Hausser, J., Berninger, P., Rothballer, A., Ascano, M., Jungkamp, A.-C., Munschauer, M., et al. (2010) · Cell · doi:10.1016/j.cell.2010.03.009 · Cited by 2,873
Park, S.-M., Gaur, A. B., Lengyel, E., & Peter, M. E. (2008) · Genes & Development · doi:10.1101/gad.1640608 · Cited by 2,272
Self-citationThe Imprinted H19 LncRNA Antagonizes Let-7 MicroRNAs
Kallen, A. N., Zhou, X.-B., Xu, J., Qiao, C., Ma, J., Yan, L., Lu, L., Liu, C., Yi, J.-S., Zhang, H., et al. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.08.027 · Cited by 1,048
Self-citationBell, J. L., Wächter, K., Mühleck, B., Pazaitis, N., Köhn, M., Lederer, M., & Hüttelmaier, S. (2013) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1186-z · Cited by 783
Metadata
- Authors
- Boyerinas, B., Park, S.-M., Shomron, N., Hedegaard, M. M., Vinther, J., Andersen, J. S., Feig, C., Xu, J., Burge, C. B., & Peter, M. E.
- Venue
- Cancer Research
- Published
- 2008-04-15
- Volume
- 68
- Issue
- 8
- Pages
- 2587-2591
- ISSN
- 0008-5472 (ISSN-L)
- 1538-7445
- OpenAlex
- W1963717607
- Cited by
- 214
- References
- 0
- FWCI
- 5.96
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Boyerinas, B., Park, S.-M., Shomron, N., Hedegaard, M. M., Vinther, J., Andersen, J. S., Feig, C., Xu, J., Burge, C. B., & Peter, M. E. (2008). Identification of Let-7–Regulated Oncofetal Genes. Cancer Research. https://doi.org/10.1158/0008-5472.can-08-0264
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