The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Tube Travel: The Role of Proteases in Individual and Collective Cancer Cell Invasion
Abstract
Recent advances in high-resolution multimodal microscopy reveal how MT1-matrix metalloproteinase (MMP)/MMP-14 and other cell surface proteases degrade and remodel the extracellular matrix (ECM) to drive the dissemination of cancer cells into normal adjacent tissue. By cleaving collagen fibers and repatterning them into parallel bundles, individual cells reorient the ECM to permit movement in tube-like microtracks. Cells along the edge of these tubes can excavate ECM outward, generating macrotracks through which collective mass movement of cancer cells can occur. These findings develop our understanding of invasive processes in cancer and how to attack them by interfering with MMP-14 activity. [Cancer Res 2008;68(18):7247–9]
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Citations
Cites
Gaggioli, C., Hooper, S., Hidalgo-Carcedo, C., Grosse, R., Marshall, J. F., Harrington, K., & Sahai, E. (2007) · Nature Cell Biology · doi:10.1038/ncb1658 · Cited by 1,589 · cited 2×
“Consequently, broadspectrum MMP inhibitors or RNA knockdown of MMP-14 abrogate collagen micropatterning and macropatterning to equal extent (14, 17).”
Background
Cited by
Hallmarks of Cancer: The Next Generation
Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590
Matrix Metalloproteinases: Regulators of the Tumor Microenvironment
Kessenbrock, K., Plaks, V., & Werb, Z. (2010) · Cell · doi:10.1016/j.cell.2010.03.015 · Cited by 5,151
Collective cell migration in morphogenesis, regeneration and cancer
Friedl, P., & Gilmour, D. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2720 · Cited by 2,712
Self-citationCancer Invasion and the Microenvironment: Plasticity and Reciprocity
Friedl, P., & Alexander, S. (2011) · Cell · doi:10.1016/j.cell.2011.11.016 · Cited by 1,940
Self-citationRole of Extracellular Matrix in Development and Cancer Progression
Walker, C., Mojares, E., & Del Río Hernández, A. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19103028 · Cited by 1,084
Metadata
- Authors
- Friedl, P., & Wolf, K.
- Venue
- Cancer Research
- Published
- 2008-09-14
- Volume
- 68
- Issue
- 18
- Pages
- 7247-7249
- ISSN
- 0008-5472 (ISSN-L)
- 1538-7445
- OpenAlex
- W2147336841
- Cited by
- 338
- References
- 1
- FWCI
- 9.10
- Type
- journal article
- Language
- en
- Open access
- closed
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- Friedl, P., & Wolf, K. (2008). Tube Travel: The Role of Proteases in Individual and Collective Cancer Cell Invasion. Cancer Research. https://doi.org/10.1158/0008-5472.can-08-0784
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
