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The High Mobility Group A1 Gene: Transforming Inflammatory Signals into Cancer?

Resar, Linda M.S.·2010·Cancer Research
DOI 10.1158/0008-5472.can-09-1212PMC PMC2807996
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Abstract

High mobility group A1 (HMGA1) is highly expressed during embryogenesis and in poorly differentiated cancers, and high levels portend a poor prognosis in some tumors. HMGA1 induces oncogenic transformation in cultured cells and causes aggressive cancers in transgenic mice, whereas blocking it interferes with transformation in experimental models. These findings suggest a pivotal role for HMGA1 in cancer. This review focuses on two recently described HMGA1 transcriptional targets that mediate inflammatory signals and drive malignant transformation because they could serve as biomarkers or therapeutic targets. Further elucidation of HMGA1 function in transformation promises to have a major impact on our war on cancer. Cancer Res; 70(2); 436–9

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  • HMGA1 promotes an inflammatory transcriptional profile, at least in part by increasing Cox-2 and STAT-3 levels.

    “Particularly relevant to the role of miR-181 repression of HMGA1 in the inflammatory response, HMGA1 has been shown to promote an inflammatory transcriptional profile, at least in part by increasing Cox-2 and STAT-3 levels (Resar, 2010 for a review; Schuldenfrei et al., 2011).”

    From Evidence for miR‐181 involvement in neuroinflammatory responses of astrocytes (2013) · cites this paper as Resar, 2010

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Cited by

Sorted by citations

Authors
Resar, L. M. S.
Affiliations
Author's Affiliation: The Johns Hopkins University School of Medicine, Baltimore, Maryland
Venue
Cancer Research
Publisher
American Association for Cancer Research (AACR)
Published
2010-01-13
Volume
70
Issue
2
Pages
436-439
ISSN
  • 0008-5472
  • 1538-7445
DOI
10.1158/0008-5472.can-09-1212
PMC
PMC2807996
Cited by
103
References
1
Language
en

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