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The Sympathetic Nervous System Induces a Metastatic Switch in Primary Breast Cancer
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Abstract
Metastasis to distant tissues is the chief driver of breast cancer–related mortality, but little is known about the systemic physiologic dynamics that regulate this process. To investigate the role of neuroendocrine activation in cancer progression, we used in vivo bioluminescence imaging to track the development of metastasis in an orthotopic mouse model of breast cancer. Stress-induced neuroendocrine activation had a negligible effect on growth of the primary tumor but induced a 30-fold increase in metastasis to distant tissues including the lymph nodes and lung. These effects were mediated by β-adrenergic signaling, which increased the infiltration of CD11b+F4/80+ macrophages into primary tumor parenchyma and thereby induced a prometastatic gene expression signature accompanied by indications of M2 macrophage differentiation. Pharmacologic activation of β-adrenergic signaling induced similar effects, and treatment of stressed animals with the β-antagonist propranolol reversed the stress-induced macrophage infiltration and inhibited tumor spread to distant tissues. The effects of stress on distant metastasis were also inhibited by in vivo macrophage suppression using the CSF-1 receptor kinase inhibitor GW2580. These findings identify activation of the sympathetic nervous system as a novel neural regulator of breast cancer metastasis and suggest new strategies for antimetastatic therapies that target the β-adrenergic induction of prometastatic gene expression in primary breast cancers. Cancer Res; 70(18); 7042–52. ©2010 AACR.
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“In the context of metastatic breast cancer, for example, stress effects on tumor metastasis are mediated by β-adrenergic up-regulation of monocytes and macrophages within the tumor microenvironment [44] (i.e., the same dynamic that drives the CTRA transcriptome shift in circulating blood [9]).”
From Human Social Genomics (2014) · cites this paper as [44]
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“Furthermore, Sloan et al. found that both stress-induced and pharmacological β-adrenergic stimulation promoted macrophage migration into tumor tissue in a mouse model of breast cancer. These macrophages then adopted an immunosuppressive M2 phenotype, leading to increased production of TGF-β, VEGF, and MMP-9, which in turn promoted angiogenesis and metastasis.322”
From Drug repurposing for cancer therapy (2024) · cites this paper as [322]
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“Parallel findings in animal and in vitro models support these data [11, 16–22].”
From Living Well: Protocol for a web-based program to improve quality of life in rural and urban ovarian cancer survivors (2024) · cites this paper as [20]
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“Parallel effects have been observed in experimental animal models of cancer, and those analyses again identify a prominent role for SNS activation of β-adrenergic signaling [43], [44].”
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Citations
Cites
Statistical Power Analysis for the Behavioral Sciences
Muller, K. E., & Cohen, J. (1989) · Technometrics · doi:10.2307/1270020 · Cited by 99,603
Statistical power analysis for the behavioral sciences
Cohen, J. (1990) · Computers Environment and Urban Systems · doi:10.1016/0198-9715(90)90050-4 · Cited by 65,417
Tumour-educated macrophages promote tumour progression and metastasis
Pollard, J. W. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1256 · Cited by 3,414
Ferguson, S. S. G. (2001) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01478-9 · Cited by 1,827
DeNardo, D. G., Barreto, J., Andreu, P., Vásquez, L. J., Tawfik, D., Kolhatkar, N. S., & Coussens, L. M. (2009) · Cancer Cell · doi:10.1016/j.ccr.2009.06.018 · Cited by 1,395
Chronic stress promotes tumor growth and angiogenesis in a mouse model of ovarian carcinoma
Thaker, P. H., Han, L. Y., Kamat, A. A., Arevalo, J. M., Takahashi, R., Lu, C., Jennings, N. B., Armaiz-Pena, G., Bankson, J. A., Ravoori, M., et al. (2006) · Nature Medicine · doi:10.1038/nm1447 · Cited by 1,320
Self-citationDo stress-related psychosocial factors contribute to cancer incidence and survival?
Chida, Y., Hamer, M., Wardle, J., & Steptoe, A. (2008) · Nature Clinical Practice Oncology · doi:10.1038/ncponc1134 · Cited by 1,072
The influence of bio-behavioural factors on tumour biology: pathways and mechanisms
Antoni, M. H., Lutgendorf, S. K., Cole, S. W., Dhabhar, F. S., Sephton, S. E., McDonald, P. G., Stefanek, M., & Sood, A. K. (2006) · Nature Reviews Cancer · doi:10.1038/nrc1820 · Cited by 981
Self-citationSocial networks, social support, and survival after breast cancer diagnosis
Kroenke, C. H., Kubzansky, L. D., Schernhammer, E. S., Holmes, M. D., & Kawachi, I. (2006) · Journal of Clinical Oncology · doi:10.1200/jco.2005.04.2846 · Cited by 792
Catecholamine Influences and Sympathetic Neural Modulation of Immune Responsiveness
Madden, K. S., Sanders, V. M., & Felten, D. L. (1995) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.35.040195.002221 · Cited by 441
Cited by
Sorted by citations
Items 701–800 of 928
Sun, J., Zhang, C., Zhong, J., & Zhou, B. (2026) · Cancer Letters · doi:10.1016/j.canlet.2026.218460 · Cited by 2
Disarming the “Neural Hijack”: Repurposing neuroactive drugs for cancer therapy
Jin, M.-Z., Dang, H.-R., & Jin, W.-L. (2026) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2026.109051 · Cited by 3
Molecular mechanisms and therapeutic targets in lung cancer–nerve crosstalk
Xu, Z., Huang, S., & Chu, Q. (2026) · Chinese Medical Journal - Pulmonary and Critical Care Medicine · doi:10.1016/j.pccm.2026.05.003 · Cited by 2
Cancer innervation: from mechanisms to clinical implications
Dai, X., Wang, X., & Wang, S. (2026) · Journal of the National Cancer Center · doi:10.1016/j.jncc.2026.06.004 · Cited by 2
Hiller, J. G., Schier, R., & Riedel, B. (2017) · Springer eBooks · doi:10.1007/978-3-319-57943-6_4 · Cited by 2
Осадча, Ю. В. (2021) · Animal Science and Food Technology · doi:10.31548/animal2021.04.005 · Cited by 2
Johnson, A. K., Lorimer, E., Szabó, A., Wu, R., Shah, N. N., D’Souza, A., Chhabra, S., Hamadani, M., Dhakal, B., Hari, P., et al. (2022) · PubMed Central · Cited by 2
Neurobiology of cancer – the role of cancer tissue innervation
Mravec, B., & Blaško, F. (2022) · Klinicka onkologie · doi:10.48095/ccko2022208 · Cited by 2
Neuroimmune Crosstalk in the Tumor Microenvironment
Krishnan, A. (2022) · Springer eBooks · doi:10.1007/978-3-030-80962-1_92-1 · Cited by 3
Blaško, F., & Horváthová, Ľ. (2024) · Endocrine Regulations · doi:10.2478/enr-2024-0008 · Cited by 2
Nakajima, K. (2014) · Springer eBooks · doi:10.1007/978-3-319-07145-9_11 · Cited by 2
Cancer recurrence, peri-operative interventions and anaesthesia: Review of current evidence
Ismail, H., & Hiller, J. G. (2012) · Sri Lankan Journal of Anaesthesiology · doi:10.4038/slja.v20i2.4494 · Cited by 2
Wang, X., & Li, S. (2015) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2015.2081 · Cited by 2
“Investigators have demonstrated that activation of the sympathetic nervous system is a novel neural regulator of breast cancer metastasis (25).”
Anestesia no paciente oncológico
Rangel, F. P., Simões, C. M., & Júnior, J. O. C. A. (2020) · Revista de Medicina · doi:10.11606/issn.1679-9836.v99i1p40-45 · Cited by 2
Selby, L. V., Fernandez-Bustamante, A., Ejaz, A. M., Gleisner, A., Pawlik, T. M., & Douin, D. J. (2021) · Journal of Gastrointestinal Surgery · doi:10.1007/s11605-021-05037-7 · Cited by 2
Sung, C.-H., Tsuang, F.-Y., Lin, C., Chan, K., Chou, W., & Wu, C. (2021) · Scientific Reports · doi:10.1038/s41598-021-95851-5 · Cited by 2
Jianqing, W., & Zha, P. (2022) · Global Journal of Cancer Therapy · doi:10.17352/2581-5407.000044 · Cited by 2
Dubowitz, J. A., Ziegler, A. I., Beare, R. J., Jost‐Brinkmann, F., Walker, A. K., Gillis, R. D., Chang, A., Chung, N.-C., Martin, O. A., Hollande, F., et al. (2023) · PLoS ONE · doi:10.1371/journal.pone.0293905 · Cited by 2
“Using three well-characterized mouse models of breast cancer progression [21–23], we investigated the effect of anesthesia with sevoflurane or propo-fol-based total intravenous anesthesia on primary tumor recurrence and metastasis onset and development.”
Self-citationIncidence and Survival in Breast Cancer Patients and Stressful Life Events
Fallah, R., Akbari, M. E., Azargashb, E., & Khayamzadeh, E. (2016) · Asian Pacific Journal of Cancer Prevention · doi:10.7314/apjcp.2016.17.s3.245 · Cited by 2
Kazi, R., & Bunimovich, Y. L. (2018) · Anti-Cancer Drugs · doi:10.1097/cad.0000000000000698 · Cited by 2
An In Vivo Mouse Model of Total Intravenous Anesthesia During Cancer Resection Surgery
Dubowitz, J. A., Jost‐Brinkmann, F., Ziegler, A. I., Gillis, R. D., Riedel, B., & Sloan, E. K. (2021) · Journal of Visualized Experiments · doi:10.3791/62747 · Cited by 2
Self-citationSurgery, Chemotherapy and Radiotherapy May Promote Cancer Growth Speeds and Shorten Patient Lives
Jianqing, W., & Zha, P. (2019) · Global Journal of Cancer Therapy · doi:10.17352/2581-5407.000043 · Cited by 4
Wu, J., & Zha, P. (2021) · OSF Preprints (OSF Preprints) · doi:10.31219/osf.io/skf8e · Cited by 2
Tumor-associated macrophages enhance tumor innervation and spinal cord repairPreprint
Dolci, S., Mannino, L., Campanelli, A., Rossi, E., Bottani, E., Ciarpella, F., Karkossa, I., Setten, E., Savino, B., Pruonto, G., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.12.19.629374 · Cited by 2
Stressed out neutrophils drive metastasis.
Lupo, F., & Coffelt, S. (2024) · Immunity · doi:10.1016/j.immuni.2024.03.013 · Cited by 1
Guo, W., & Shi, R. (2024) · Journal of Experimental and Clinical Application of Chinese Medicine · doi:10.62767/jecacm501.8668 · Cited by 1
Association between resting heart rate and prognosis in patients with gastric cancer
Lee, D. H., Park, D., Lee, T. H., Giovannucci, E. L., Park, S. H., Cho, G. S., Kim, Y. M., Hyung, W. J., Jeon, J. Y., & Kim, H. (2025) · Scientific Reports · doi:10.1038/s41598-025-89577-x · Cited by 1
Hongdan, C. H. E. N., Zhang, L., & Li, C. (2025) · Journal of Zhejiang University (Medical Sciences) · doi:10.3724/zdxbyxb-2025-0090 · Cited by 2
Telonis, A. G., Hernandez, A. E., Borowsky, P. A., Hernandez, E. D. R., Lyon, P. D., Cimmino, L., Garcia-Martinez, L., Zha, M., Morey, L., Net, J., et al. (2025) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-25-0123 · Cited by 1
Modi, N. D., Abuhelwa, A. Y., Kuderer, N. M., Li, L. X., Lyman, G. H., Koczwara, B., Kichenadasse, G., Selth, L. A., Rickard, C., Haseloff, M., et al. (2025) · Cancer Medicine · doi:10.1002/cam4.71320 · Cited by 1
Liang, M., Wang, J., Li, R., Yang, J., Liu, Y., & Zhao, L. (2025) · Medicine · doi:10.1097/md.0000000000045653
Zhang, L., Huang, X., Wang, S., Chen, S., Wang, J., Chen, L., & Sun, P. (2025) · Human Mutation · doi:10.1155/humu/8719836 · Cited by 1
“Preclinical investigations con fi rm this link, demonstrating that autonomic β -adrenergic signaling can accelerate tumor progression in breast and ovarian cancers [42, 43] and that diverse neuronal subtypes are instrumental to proliferation across various malignancies.”
Li, R., Chen, J., Chen, Y., Jin, K., Chen, Y., Deng, C., Liu, X., & Li, Y. (2026) · Clinical Medicine Insights Oncology · doi:10.1177/11795549251411762 · Cited by 3
“11,12 Given the potential to modulate the sympathetic nervous system, beta blockers (BBs) have emerged as promising candidates for repurposing in oncology.”
Brain-cancer interactions outside the CNS
Li, W., Huo, R., Liu, S., He, K., Wu, H., Wang, H., Jiang, S., & Xue, J. (2026) · Oncogene · doi:10.1038/s41388-026-03684-1 · Cited by 1
“This process promotes M2-like polarization and facilitates distant metastasis to organs such as the lung and lymph nodes [41].”
Courtes, A. C., Myers, B., Daly, N., Jones, G., Soares, J. C., Zarate, C. A., & Machado‐Vieira, R. (2026) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2026.02.011 · Cited by 1
Beyond tumor biology: nursing interventions for psychological and immune health in cancer patients
Gou, Y. R., Gu, H., & Wang, L. (2026) · Supportive Care in Cancer · doi:10.1007/s00520-026-10574-5 · Cited by 1
Liu, J., Qin, J., Zheng, W., Wang, X., Wei, Z., Xie, Z., Yan, T., Li, X. W., Ding, Z., Liu, H., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-72847-1 · Cited by 2
“Pharmacological block-adeofADRB2decreasednervein fi ltrationwithintumors 16 ,reducedthe number of macrophages in tumor tissues, and inhibited their polarization into the M2 phenotype 18,19 , thereby slowing tumor development and metastasis and enhancing chemotherapy sensitivity 7,16,28,29 .”
InfluentialChronic psychosocial stress: a role in breast cancer etiology?
Fosse, R., & Behr, C. (2026) · Frontiers in Oncology · doi:10.3389/fonc.2026.1790548 · Cited by 1
“Do preclinical in vivo studies provide evidence that chronic psychosocial stress contributes to initiating BC tumor formation, rather than only tumor growth and metastasis after its initiation (37, 94)?”
Psychoneuroimmunology and Cancer: Biobehavioral Influences on Tumor Progression
Lutgendorf, S. K., Costanzo, E. S., & Sood, A. K. (2012) · Oxford University Press eBooks · doi:10.1093/oxfordhb/9780195394399.013.0019 · Cited by 1
Self-citationHuerta, M. S. S., López, C. G. F., Díaz, B. C., & García, R. R. G. R. (2016) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) · Cited by 1
Distress andneoangiogenesis in ovarian cancer patients
Guens, G. P., Oleynikova, I. N., Sirota, N. A., Моисеева, Н. И., Shikina, V. Е., & Kirkin, V. V. (2019) · Siberian Journal of Oncology · doi:10.21294/1814-4861-2019-18-2-22-27 · Cited by 1
Social Genomics and Cancer: Neural Regulation of the Cancer Genome
Knight, J. M., & Cole, S. W. (2022) · Springer eBooks · doi:10.1007/978-3-030-85702-8_21 · Cited by 1
Self-citationAydın, B., Gören, M. Z., Kanlı, Z., & Cabadak, H. (2022) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.13627 · Cited by 1
Greenberger, S. (2018) · Springer eBooks · doi:10.1007/978-3-319-72156-9_16 · Cited by 1
Neurogenesis in the Tumor Microenvironment
Vethe, H., Bjørnstad, O. V., Carrasco, M., & Akslen, L. A. (2022) · Springer eBooks · doi:10.1007/978-3-030-98950-7_16 · Cited by 1
The Role of the Microenvironment in Tumor Promoting Stress Responses
Dillekås, H., Schuster, C., Davidsen, K. T., & Straume, O. (2022) · Springer eBooks · doi:10.1007/978-3-030-98950-7_31 · Cited by 1
Tumor-Nerve Interface: An Emerging Therapeutic Intervention Point for Solid Cancers
Krishnan, A. (2022) · Interdisciplinary cancer research · doi:10.1007/16833_2022_35 · Cited by 1
Canali, M. M., Guyot, M., Simon, T., Daoudlarian, D., Chabry, J., Panzolini, C., Petit-Paitel, A., Hypolite, N., Nicolas, S., Bourdely, P., et al. (2023) · Cancer Cell International · doi:10.1186/s12935-023-02855-4 · Cited by 1
Flawed foundation is the root cause of failure of medicine and precludes cures for chronic diseases
Jianqing, W., & Zha, P. (2023) · Global Journal of Cancer Therapy · doi:10.17352/2581-5407.000050 · Cited by 2
Yang, R., Rush, T., & Huang, C. (2023) · Springer eBooks · doi:10.1007/978-3-031-50977-3_8 · Cited by 1
Shakery, A., Pourvali, K., Shimi, G., & Zand, H. (2023) · PubMed Central · doi:10.22088/ijmcm.bums.12.2.144 · Cited by 1
Wang, Y., Guan, W., Zhang, Y., Wang, Y., Shi, B., Liu, J., & Zhang, S. (2024) · Oncology Letters · doi:10.3892/ol.2024.14632 · Cited by 1
Mravec, B. (2024) · Springer eBooks · doi:10.1007/978-3-031-68590-3_37 · Cited by 1
Involvement of sympathetic nerves in bone metastasis
Elefteriou, F., & Campbell, P. J. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-416721-6.00049-2 · Cited by 1
Infantile Hemangioma: New Insights on Pathogenesis and Beta Blockers Mechanisms of Action
Greenberger, S. (2017) · Springer eBooks · doi:10.1007/978-1-4471-7314-4_2 · Cited by 1
β-adrenergic receptor-dependent and -independent effects of propranolol in infantile hemangioma
Kum, J. J. Y. (2015) · Scholarship@Western (Western University) · Cited by 1
Neuroimmunoendocrine Interactions in Tumorigenesis and Breast Cancer
Ruiz‐Manzano, R. A., Ochoa-Mercado, T. D. L., Mendoza, M. S., Castro, K. E. N., Arreola, M. I. P., & Morales‐Montor, J. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.88128 · Cited by 1
Viability and reproductive function of chickens under changes in the height of cage battery location
Osadcha, Y. (2021) · Taurian Scientific Herald · doi:10.32851/2226-0099.2021.121.25 · Cited by 1
Cancer Biology and Implications for the Perioperative Period
Perry, N. J. S., Jhanji, S., & Poulogiannis, G. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-69584-8.00003-7 · Cited by 1
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Осадча, Ю. (2021) · Аграрний вісник Причорномор я · doi:10.37000/abbsl.2021.101.03 · Cited by 1
Erickson, J. R., Pahlkotter, M. K., Thielking, P. D., Porretta, J. M., Rosenthal, R., Matsen, C. B., & Brownson, K. E. (2023) · Patient Experience Journal · doi:10.35680/2372-0247.1645 · Cited by 1
“5,6 Unlike most other health outcome risk factors, the detrimental effects of social isolation seem to be based on the individual’s interpretation of isolation.”
BackgroundDoes Our “Flight and Fight” Response Have a Link With Cancer?
Kohli, M. (2013) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2013.09.005 · Cited by 1
A novel role for macrophages in peripheral nerve regeneration
Emmenis, L. V. (2018) · UCL Discovery (University College London) · Cited by 1
Daher, C., Vimeux, L., Stoeva, R., Peranzoni, E., Bismuth, G., Donnadieu, E., Bercovici, N., Trautmann, A., & Feuillet, V. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/497263 · Cited by 1
Effects of Epinephrine on Gastric Adenocarcinoma and Brain Glioblastoma Cancer CellsPreprint
Shafaroudi, M. M., Rezaei, N., Noori, A., Zarei, H., Akhtari, J., Abediankenari, S., & Shafaroudi, A. M. (2021) · Research Square · doi:10.21203/rs.3.rs-443068/v1 · Cited by 1
Davis, C. M. (2013) · eScholarship (California Digital Library)
A Proposed Mathematical Model of Tumor Growth and Host Consciousness
Kozłowski, M., & Janina Marciak-kozlowska, B. (2011) · NeuroQuantology · doi:10.14704/nq.2011.9.4.411
Will β-Blockers Live up to the Maxim of Sir James Black, Their Creator?
Al-Waili, K., Al‐Rasadi, K., & Banerjee, Y. (2012) · Angiology · doi:10.1177/0003319711434636
Could β-Blockers be a Feasible Treatment option for Lung Cancer?
Wang, H., Gomez, D. R., & Liao, Z. X. (2013) · Lung Cancer Management · doi:10.2217/lmt.13.27
Advanced Cancer Treatment – An Original Approach
Bukhtoyarov, O. V., & Самарин, Д. М. (2015) · InTech eBooks · doi:10.5772/60213
The role of myeloid cells in breast cancer metastasis
Swierczak, A. (2012) · Minerva Access (University of Melbourne)
The Role of Glucocorticoid Receptor in the Racial/Ethnic Disparity of Aggressive Breast Cancer
Al‐Alem, U. (2015) · Figshare
Integrative Oncology Exceptional Patients - Thoughts and Reflections
Frenkel, M. A. (2013)
Perioperative care and cancer recurrence: Is there a connection
Khanna, A. K. (2014) · World Journal of Anesthesiology · doi:10.5313/wja.v3.i1.31
Csef, H., & Hefner, J. (2012) · gynäkologie + geburtshilfe · doi:10.1007/s15013-012-0204-4
Maru, Y. (2016) · Springer eBooks · doi:10.1007/978-4-431-56024-1_12
Mehrdad, Z., Eshaghi, M., Reza, S. M., Naji, H., Masoud, M. S. M., & Sedigheh, A. (2016)
- Self-citation
Lumpkin, M. D. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802381-5.00026-9
A Review of Cancer Immunotherapy and Nutritional Therapies
Westman, J. C. (2017) · Journal of Neoplasm · doi:10.21767/2576-3903.100017
Cancer Biology: a Primer for Perioperative Clinicians
Wilks, J. A. (2018) · Current anesthesiology reports · doi:10.1007/s40140-018-0302-5
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Star, S. (2018) · Minerva Access (University of Melbourne)
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Jianqing, W., & Zha, P. (2019)
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Rekha, S., Peerapur, S. M., Roy, A., & Tejaswini, B. (2020) · IP Journal of Paediatrics and Nursing Science · doi:10.18231/j.ijpns.2019.001
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Anupozu, R. (2020) · Asian Journal of Pharmaceutical and Clinical Research · doi:10.22159/ajpcr.2020.v13i10.38705
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Anker, M. S., Hadzibegovic, S., & von Haehling, S. (2020) · Der Internist · doi:10.1007/s00108-020-00887-w
Jośko-Ochojska, J., & Brus, R. (2020) · Annales Academiae Medicae Silesiensis · doi:10.18794/aams/117864
Death of a Child and Mortality after Cancer: A Nationwide Cohort Study in Sweden
Wang, Y., Wei, D., Chen, H., Chen, B., Li, J., & László, K. D. (2020) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-20-0842
Who is implicated in the care of digestive cancers
Vernet, C., Lepage, C., Lejeune, C., Faivre, J., & Bouvier, A. (2008)
Perioperative use of β-blockers in oncological patients
Сорочан, П. П., Hromakova, I. А., Prokhach, N. E., Роnomarev, I. M., & Hromakova, I. S. (2021) · Український радіологічний та онкологічний журнал · doi:10.46879/ukroj.1.2021.119-132
Botteri, E., Baker, J. G., & Sloan, E. K. (2021) · European Journal of Cancer · doi:10.1016/j.ejca.2021.04.022
Self-citationAnti-Lethal Therapy of COVID-19 for Home Health Outpatient Therapy
Bukhtoyarov, O. V., & Самарин, Д. М. (2021) · European Journal of Medical and Health Sciences · doi:10.24018/ejmed.2021.3.4.960
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Rossel, T., Zhang, B., & Gobat, R. (2020) · ChemRxiv · doi:10.26434/chemrxiv.12084390.v3
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Rossel, T., Bing, Z., & Gobat, R. (2021) · doi:10.33774/chemrxiv-2021-ghnkr-v5
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Geng, Q., Shen, Z., Zheng, Y., Xue, W., Li, L., & Zhao, J. (2021) · Cell Transplantation · doi:10.1177/09636897211049813
Rossel, T., Zhang, B., & Gobat, R. (2020) · ChemRxiv · doi:10.26434/chemrxiv.12084390.v1
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Fink, M. (2014) · Info Onkologie · doi:10.1007/s15004-014-0752-y
No Impact of Psychosocial Stress on Glioblastoma DevelopmentPreprint
Durrechou, Q., Engelhardt, J., Jecko, V., Domblides, C., Catry‐Thomas, I., Loiseau, H., Planchon, C., Grimal, S. D., & Bronnimann, C. (2021) · Research Square · doi:10.21203/rs.3.rs-1138824/v1
“[21,24] In several publications, stress-related psychosocial factors have been suggested to contribute to incidence of cancer, tumour progression and worst survival in cancer patients [9,25] but most studies have focused on high-incidence cancer (especially in breast cancer [26-28] ).”
Metadata
- Authors
- Sloan, E. K., Priceman, S. J., Cox, B. F., Yu, S., Pimentel, M. A., Tangkanangnukul, V., Arevalo, J. M. G., Morizono, K., Karanikolas, B. D. W., Wu, L., Sood, A. K., & Cole, S. W.
- Affiliations
- University of California, Los Angeles (US)
- Authors' Affiliations: 1UCLA Norman Cousins Center at the Semel Institute for Neuroscience and Human Behavior, Department of Medicine, 2Division of Hematology-Oncology, UCLA School of Medicine, UCLA AIDS Institute, 3Jonsson Comprehensive Cancer Center, 4UCLA Department of Molecular and Medical Pharmacology, and 5UCLA Molecular Biology Institute, Los Angeles, California; and 6Departments of Gynecologic Oncology and Cancer Biology, M.D. Anderson Comprehensive Cancer Center, Houston, Texas
- Corresponding author
- Sloan, Erica K.
- ORCID
- Venue
- Cancer Research
- Published
- 2010-09-14
- Volume
- 70
- Issue
- 18
- Pages
- 7042-7052
- ISSN
- 0008-5472 (ISSN-L)
- 1538-7445
- PMC
- PMC2940980
- OpenAlex
- W2107567947
- Cited by
- 930
- References
- 53
- Citations by year
- 2026: 97 · 2025: 76 · 2024: 72 · 2023: 63 · 2022: 78 · 2021: 94 · 2020: 59 · 2019: 65 · 2018: 42 · 2017: 40 · 2016: 45 · 2015: 50 · 2014: 38 · 2013: 49 · 2012: 32
- FWCI
- 23.85
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cancer Research (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (CA 109298, R01CA110793, CA 110793, R01CA109298, R01CA116778, CA-116778, R21CA138687, CA138687, R01CA160890)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Stress, Anesthesia, and Immune Response
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Keywords
- breast cancer metastasis, sympathetic nervous system, neuroendocrine activation, stress, beta-adrenergic signaling, tumor-associated macrophages, M2 macrophage polarization, propranolol, GW2580, lymph node metastasis, lung metastasis, orthotopic mouse model, anti-metastatic therapy
- MeSH terms
- Adenocarcinoma, Animals, Female, Macrophages, Mammary Neoplasms, Experimental, Mice, Inbred BALB C, Mice, Nude, Neoplasm Metastasis, Stress, Physiological, Sympathetic Nervous System, T-Lymphocytes, Cell Line, Tumor, Mice
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