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Tumorigenic and Metastatic Activity of Human Thyroid Cancer Stem Cells
Abstract
Thyroid carcinoma is the most common endocrine malignancy and the first cause of death among endocrine cancers. We show that the tumorigenic capacity in thyroid cancer is confined in a small subpopulation of stem-like cells with high aldehyde dehydrogenase (ALDHhigh) activity and unlimited replication potential. ALDHhigh cells can be expanded indefinitely in vitro as tumor spheres, which retain the tumorigenic potential upon delivery in immunocompromised mice. Orthotopic injection of minute numbers of thyroid cancer stem cells recapitulates the behavior of the parental tumor, including the aggressive metastatic features of undifferentiated thyroid carcinomas, which are sustained by constitutive activation of cMet and Akt in thyroid cancer stem cells. The identification of tumorigenic and metastagenic thyroid cancer cells may provide unprecedented preclinical tools for development and preclinical validation of novel targeted therapies. Cancer Res; 70(21); 8874–85. ©2010 AACR.
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MET Amplification Leads to Gefitinib Resistance in Lung Cancer by Activating ERBB3 Signaling
Engelman, J. A., Zejnullahu, K., Mitsudomi, T., Song, Y., Hyland, C., Park, J. O., Lindeman, N., Gale, C.-M., Zhao, X., Christensen, J., et al. (2007) · Science · doi:10.1126/science.1141478 · Cited by 4,496
Met acts on Mdm2 via mTOR to signal cell survival during development
Moumen, A., Patané, S., Porras, A., Dono, R., & Maina, F. (2007) · Development · doi:10.1242/dev.02820 · Cited by 95
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ALDH1A Isozymes are Markers of Human Melanoma Stem Cells and Potential Therapeutic Targets
Luo, Y., Dallaglio, K., Chen, Y., Robinson, W. A., Robinson, S. E., McCarter, M. D., Wang, J., Gonzalez, R., Thompson, D. C., Norris, D. A., et al. (2012) · Stem Cells · doi:10.1002/stem.1193 · Cited by 281
Regulation of Stem Cell Plasticity: Mechanisms and Relevance to Tissue Biology and Cancer
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Metadata
- Authors
- Todaro, M., Iovino, F., Eterno, V., Cammareri, P., Gambara, G., Espina, V., Gulotta, G., Dieli, F., Giordano, S., De Maria, R., & Stassi, G.
- Venue
- Cancer Research
- Published
- 2010-10-31
- Volume
- 70
- Issue
- 21
- Pages
- 8874-8885
- ISSN
- 0008-5472 (ISSN-L)
- 1538-7445
- OpenAlex
- W2170798389
- Cited by
- 218
- References
- 2
- FWCI
- 13.21
- Type
- journal article
- Language
- en
- Open access
- closed
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- Todaro, M., Iovino, F., Eterno, V., Cammareri, P., Gambara, G., Espina, V., Gulotta, G., Dieli, F., Giordano, S., De Maria, R., & Stassi, G. (2010). Tumorigenic and Metastatic Activity of Human Thyroid Cancer Stem Cells. Cancer Research. https://doi.org/10.1158/0008-5472.can-10-1994
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