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The Promise of MicroRNA Replacement Therapy
Open accessAbstract
MicroRNAs (miRNA), a class of natural RNA-interfering agents, have recently been identified as attractive targets for therapeutic intervention. The rationale for developing miRNA therapeutics is based on the premise that aberrantly expressed miRNAs play key roles in the development of human disease, and that correcting these miRNA deficiencies by either antagonizing or restoring miRNA function may provide a therapeutic benefit. Although miRNA antagonists are conceptually similar to other inhibitory therapies, restoring the function of a miRNA by miRNA replacement is a less well characterized approach. Here, we discuss the specific properties of miRNA replacement and review recent examples that explored the therapeutic delivery of miRNA mimics in animal models of cancer. Cancer Res; 70(18); 7027–30. ©2010 AACR.
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Bartel (2004) · doi:10.1016/s0092-8674(04)00045-5 · Cited by 34,714
Cited by
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Trang, P., Wiggins, J. F., Daige, C. L., Cho, C., Omotola, M., Brown, D., Weidhaas, J. B., Bader, A. G., & Slack, F. J. (2011) · Molecular Therapy · doi:10.1038/mt.2011.48 · Cited by 667
Self-citationBernardo, B. C., Gao, X.-M., Winbanks, C. E., Boey, E. J. H., Tham, Y. K., Kiriazis, H., Gregorevic, P., Obad, S., Kauppinen, S., Du, X.-J., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1206432109 · Cited by 429
MicroRNA therapeutics: Discovering novel targets and developing specific therapy
Bansal, P., Christopher, A., Kaur, R., Kaur, G., Kaur, A., & Gupta, V. (2016) · Perspectives in Clinical Research · doi:10.4103/2229-3485.179431 · Cited by 360
RNAi-Based Therapeutics and Novel RNA Bioengineering Technologies
Traber, G. M., & Yu, A.-M. (2023) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.122.001234 · Cited by 291
Metadata
- Authors
- Bader, A. G., Brown, D., & Winkler, M.
- Venue
- Cancer Research
- Published
- 2010-09-14
- Volume
- 70
- Issue
- 18
- Pages
- 7027-7030
- ISSN
- 0008-5472 (ISSN-L)
- 1538-7445
- OpenAlex
- W2102627944
- Cited by
- 617
- References
- 1
- FWCI
- 13.19
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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