Cited by 256Autophagy in Disease and TherapyCancer, Hypoxia, and MetabolismCancer Immunotherapy and Biomarkers

The DOI matches its Crossref record; 43 of the 44 references it cites were found in a registry or an index.

Blocking Hypoxia-Induced Autophagy in Tumors Restores Cytotoxic T-Cell Activity and Promotes Regression

Noman, Muhammad Zaeem, Janji, Bassam, Kaminska, Bozena, Van Moer, Kris, Pierson, Sandrine, Przanowski, Piotr, Buart, Stéphanie, Berchem, Guy, Romero, Pedro, Mami-Chouaib, Fathia, Chouaib, Salem·2011·Cancer Research

DOI 10.1158/0008-5472.can-11-1094

Published version of a preprint

Open this paper in CoChat — free account

Abstract

The relationship between hypoxic stress, autophagy, and specific cell-mediated cytotoxicity remains unknown. This study shows that hypoxia-induced resistance of lung tumor to cytolytic T lymphocyte (CTL)–mediated lysis is associated with autophagy induction in target cells. In turn, this correlates with STAT3 phosphorylation on tyrosine 705 residue (pSTAT3) and HIF-1α accumulation. Inhibition of autophagy by siRNA targeting of either beclin1 or Atg5 resulted in impairment of pSTAT3 and restoration of hypoxic tumor cell susceptibility to CTL-mediated lysis. Furthermore, inhibition of pSTAT3 in hypoxic Atg5 or beclin1-targeted tumor cells was found to be associated with the inhibition Src kinase (pSrc). Autophagy-induced pSTAT3 and pSrc regulation seemed to involve the ubiquitin proteasome system and p62/SQSTM1. In vivo experiments using B16-F10 melanoma tumor cells indicated that depletion of beclin1 resulted in an inhibition of B16-F10 tumor growth and increased tumor apoptosis. Moreover, in vivo inhibition of autophagy by hydroxychloroquine in B16-F10 tumor-bearing mice and mice vaccinated with tyrosinase-related protein-2 peptide dramatically increased tumor growth inhibition. Collectively, this study establishes a novel functional link between hypoxia-induced autophagy and the regulation of antigen-specific T-cell lysis and points to a major role of autophagy in the control of in vivo tumor growth. Cancer Res; 71(18); 5976–86. ©2011 AACR.

Integrity signals

Registry

Crossref · 10.1158/0008-5472.can-11-1094

Cites

43 of 43 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Autophagy in the Pathogenesis of Disease
Levine, B., & Kroemer, G. (2008) · Cell · doi:10.1016/j.cell.2007.12.018 · Cited by 7,069
Cancer immunotherapy: moving beyond current vaccines
Rosenberg, S. A., Yang, J. C.-H., & Restifo, N. P. (2004) · Nature Medicine · doi:10.1038/nm1100 · Cited by 2,980
Stat3 as an Oncogene
Bromberg, J. F., Wrzeszczynska, M. H., Devgan, G., Zhao, Y., Pestell, R. G., Albanese, C., & Darnell, J. E. (1999) · Cell · doi:10.1016/s0092-8674(00)81959-5 · Cited by 2,790
Immunologic and therapeutic evaluation of a synthetic peptide vaccine for the treatment of patients with metastatic melanoma
Rosenberg, S. A., Yang, J. C., Schwartzentruber, D. J., Hwu, P., Marincola, F. M., Topalian, S. L., Restifo, N. P., Dudley, M. E., Schwarz, S. L., Spiess, P. J., et al. (1998) · Nature Medicine · doi:10.1038/nm0398-321 · Cited by 1,786
Hypoxia-Induced Autophagy Is Mediated through Hypoxia-Inducible Factor Induction of BNIP3 and BNIP3L via Their BH3 Domains
Bellot, G., Garcia-Medina, R., Gounon, P., Chiche, J., Roux, D., Pouysségur, J., & Mazure, N. M. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.00166-09 · Cited by 1,501
Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma
Amaravadi, R. K., Yu, D., Lum, J. J., Bui, T., Christophorou, M. A., Evan, G. I., Thomas‐Tikhonenko, A., & Thompson, C. B. (2007) · Journal of Clinical Investigation · doi:10.1172/jci28833 · Cited by 1,158
Integration of Oxygen Signaling at the Consensus HRE
Wenger, R. H., Stiehl, D. P., & Camenisch, G. (2005) · Science's STKE · doi:10.1126/stke.3062005re12 · Cited by 1,032
Potential therapeutic applications of autophagy
Rubinsztein, D. C., Gestwicki, J. E., Murphy, L. O., & Klionsky, D. J. (2007) · Nature Reviews Drug Discovery · doi:10.1038/nrd2272 · Cited by 862
The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5
Rouschop, K. M. A., van den Beucken, T., Dubois, L., Niessen, H., Bussink, J., Savelkouls, K., Keulers, T., Mujcic, H., Landuyt, W., Voncken, J. W., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci40027 · Cited by 829
Linking of autophagy to ubiquitin-proteasome system is important for the regulation of endoplasmic reticulum stress and cell viability.
Ding, W.-X., Ni, H.-M., Gao, W., Yoshimori, T., Stolz, D. B., Ron, D., & Yin, X.-M. (2007) · The American Journal of Pathology · doi:10.2353/ajpath.2007.070188 · Cited by 708

Show all 44 references

Sorted by citations

Items 101–200 of 256

Inhibition of autophagy with chloroquine is effective in melanoma
Egger, M. E., Huang, J. S., Yin, W., McMasters, K. M., & McNally, L. R. (2013) · Journal of Surgical Research · doi:10.1016/j.jss.2013.04.055 · Cited by 57
Tumor suppression in mice lacking GABARAP, an Atg8/LC3 family member implicated in autophagy, is associated with alterations in cytokine secretion and cell death
Salah, F. S., Ebbinghaus, M., Muley, V. Y., Zhou, Z., Al-Saadi, K. R., Pacyna-Gengelbach, M., O’Sullivan, G. A., Betz, H., König, R., Wang, Z.-Q., et al. (2016) · Cell Death and Disease · doi:10.1038/cddis.2016.93 · Cited by 56
Synergy of Tumor Microenvironment Remodeling and Autophagy Inhibition to Sensitize Radiation for Bladder Cancer Treatment
Lin, T., Zhang, Q., Yuan, A., Wang, B., Zhang, F., Ding, Y., Cao, W., Chen, W., & Guo, H. (2020) · Theranostics · doi:10.7150/thno.45358 · Cited by 56
Relationship between autophagy and perineural invasion, clinicopathological features, and prognosis in pancreatic cancer
Yang, Y., Liu, J., Gui, Y., Lei, L., & Zhang, S. (2017) · World Journal of Gastroenterology · doi:10.3748/wjg.v23.i40.7232 · Cited by 51
Autophagy Takes Center Stage as a Possible Cancer Hallmark
Alvarez-Meythaler, J. G., Garcia‐Mayea, Y., Mir, C., Kondoh, H., & LLeonart, M. E. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.586069 · Cited by 59
The interplay between autophagy and cGAS-STING signaling and its implications for cancer
Schmid, M., Fischer, P., Engl, M., Widder, J., Gruber, S., & Slade, D. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1356369 · Cited by 61
Hypoxia as a potential inducer of immune tolerance, tumor plasticity and a driver of tumor mutational burden: Impact on cancer immunotherapy
Khouzam, R. A., Janji, B., Thiery, J., Zaarour, R. F., Chamseddine, A. N., Mayr, H., Savagner, P., Kiéda, C., Gad, S., Buart, S., et al. (2023) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2023.11.008 · Cited by 54
Self-citation
Therapeutic Targeting of Autophagy for Renal Cell Carcinoma Therapy
Jones, T. M., Carew, J. S., & Nawrocki, S. T. (2020) · Cancers · doi:10.3390/cancers12051185 · Cited by 49
Intracellular Proton Pumps as Targets in Chemotherapy: V-ATPases and Cancer
Hernández, A., Serrano, G., Pérez‐Castiñeira, J. R., & Serrano, A. (2012) · Current Pharmaceutical Design · doi:10.2174/138161212799504821 · Cited by 48
Dasatinib promotes the expansion of a therapeutically superior T-cell repertoire in response to dendritic cell vaccination against melanoma
Lowe, D. B., Bose, A., Taylor, J. L., Tawbi, H. A.-H., Lin, Y., Kirkwood, J. M., & Storkus, W. J. (2014) · OncoImmunology · doi:10.4161/onci.27589 · Cited by 47
Autophagy and Its Role in Protein Secretion: Implications for Cancer Therapy
Cotzomi-Ortega, I., Aguilar‐Alonso, P., Reyes‐Leyva, J., & Maycotte, P. (2018) · Mediators of Inflammation · doi:10.1155/2018/4231591 · Cited by 47
The pleiotropic functions of autophagy in metastasis
Marsh, T., Tolani, B., & Debnath, J. (2021) · Journal of Cell Science · doi:10.1242/jcs.247056 · Cited by 49
How to overcome tumor resistance to anti-PD-1/PD-L1 therapy by immunotherapy modifying the tumor microenvironment in MSS CRC
Chen, L., Jiang, X., Li, Y., Zhang, Q., Li, Q., Zhang, X., Zhang, M., Yu, Q., & Gao, D. (2022) · Clinical Immunology · doi:10.1016/j.clim.2022.108962 · Cited by 46
The role of hypoxia in shaping the recruitment of proangiogenic and immunosuppressive cells in the tumor microenvironment
Chouaı̈b, S., Umansky, V., & Kiéda, C. (2018) · Współczesna Onkologia · doi:10.5114/wo.2018.73874 · Cited by 45
The functions of autophagy at the tumour‐immune interface
Luo, X., Qiu, Y., Dinesh, P., Gong, W., Jiang, L., Feng, X., Li, J., Jiang, Y., Lei, Y. L., & Chen, Q. (2021) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.16331 · Cited by 45
Targeting Cytoprotective Autophagy to Enhance Anticancer Therapies
Xiao, M., Benoit, A., Hasmim, M., Duhem, C., Vogin, G., Berchem, G., Noman, M. Z., & Janji, B. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.626309 · Cited by 47
Self-citation
The Role of Autophagy in Pancreatic Cancer: From Bench to the Dark Bedside
Görgülü, K., Diakopoulos, K. N., Kaya-Aksoy, E., Ciecielski, K. J., Ai, J., Lesina, M., & Algül, H. (2020) · Cells · doi:10.3390/cells9041063 · Cited by 43
Lighting up the fire in the microenvironment of cold tumors: a major challenge to improve cancer immunotherapy
Benoit, A., Vogin, G., Duhem, C., Berchem, G., & Janji, B. (2023) · Cells · doi:10.3390/cells12131787 · Cited by 39
“Interestingly, blocking hypoxia-induced autophagy restored cytotoxic T cell activity and promoted tumor regression [139].”
BackgroundSelf-citation
Cutting Edge: NANOG Activates Autophagy under Hypoxic Stress by Binding to BNIP3L Promoter
Hasmim, M., Janji, B., Khaled, M., Noman, M. Z., Louache, F., Bordereaux, D., Abderamane, A., Baud, V., Mami‐Chouaib, F., & Chouaı̈b, S. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1600981 · Cited by 40
Self-citation
Autophagy-inhibiting biomimetic nanodrugs enhance photothermal therapy and boost antitumor immunity
Huang, P., Zhu, Y.-Y., Zhong, H., Chen, P., Shi, Q., Chen, J., Lai, J.-M., Tu, Y., Liu, S., & Liu, L. (2022) · Biomaterials Science · doi:10.1039/d1bm01888d · Cited by 39
Seeking new anti-cancer agents from autophagy-regulating natural products
Hua, F., Shang, S., & Hu, Z. (2017) · Journal of Asian Natural Products Research · doi:10.1080/10286020.2017.1304385 · Cited by 38
The role of hypoxic signalling in metastasis: towards translating knowledge of basic biology into novel anti-tumour strategies
Henríquez, J. A., Sleeman, J. P., & Garvalov, B. K. (2018) · Clinical & Experimental Metastasis · doi:10.1007/s10585-018-9930-x · Cited by 37
Emerging Cancer Therapeutic Targets in Protein Homeostasis
Bastola, P., Oien, D. B., Cooley, M., & CHIEN, J. R. (2018) · The AAPS Journal · doi:10.1208/s12248-018-0254-1 · Cited by 39
A Stressful Microenvironment: Opposing Effects of the Endoplasmic Reticulum Stress Response in the Suppression and Enhancement of Adaptive Tumor Immunity
Rausch, M. P., & Sertil, A. R. (2015) · International Reviews of Immunology · doi:10.3109/08830185.2015.1018415 · Cited by 35
Old and New Players of Inflammation and Their Relationship With Cancer Development
Chavez-Dominguez, R., Perez-Medina, M., Aguilar‐Cázares, D., Galicia-Velasco, M., Meneses-Flores, M., Islas-Vázquez, L., Camarena, Á., & López-González, J. S. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.722999 · Cited by 40
Modulation of Autophagy Direction to Enhance Antitumor Effect of Endoplasmic‐Reticulum‐Targeted Therapy: Left or Right?
Shen, X., Deng, Y., Chen, L., Liu, C., Li, L., & Huang, Y. (2023) · Advanced Science · doi:10.1002/advs.202301434 · Cited by 34
Selective Reversible Inhibition of Autophagy in Hypoxic Breast Cancer Cells Promotes Pulmonary Metastasis
Dower, C. M., Bhat, N., Wang, W., & Wang, H. (2016) · Cancer Research · doi:10.1158/0008-5472.can-15-3458 · Cited by 35
Semaphorin 3A causes immune suppression by inducing cytoskeletal paralysis in tumour-specific CD8+ T cells
Barnkob, M. B., Michaels, Y. S., André, V., Macklin, P. S., Gileadi, U., Valvo, S., Rei, M., Kulicke, C. A., Chen, J., Jain, V., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-47424-z · Cited by 34
Irradiation combined with PD-L1−/− and autophagy inhibition enhances the antitumor effect of lung cancer via cGAS-STING-mediated T cell activation
Zhao, X., Hu, S., Zeng, L., Liu, X., Song, Y., Zhang, Y., Chen, Q., Bai, Y., Zhang, J., Zhang, H., et al. (2022) · iScience · doi:10.1016/j.isci.2022.104690 · Cited by 36
The role of autophagy in colorectal cancer: Impact on pathogenesis and implications in therapy
Mahgoub, E., Taneera, J., Sulaiman, N. D., & Saber-Ayad, M. M. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.959348 · Cited by 33
Autophagy and senescence in cancer therapy
Patel, N. H., Bloukh, S., Alwohosh, E., Alhesa, A., Saleh, T., & Gewirtz, D. A. (2021) · Advances in cancer research · doi:10.1016/bs.acr.2021.01.002 · Cited by 36
Recent Advances of Autophagy in Non-Small Cell Lung Cancer: From Basic Mechanisms to Clinical Application
Guo, W., Du, K., Luo, S., & Hu, D. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.861959 · Cited by 34
Adapt, Recycle, and Move on: Proteostasis and Trafficking Mechanisms in Melanoma
Demirsoy, Ş., Martín-Acebes, M. A., Maes, H., & Agostinis, P. (2016) · Frontiers in Oncology · doi:10.3389/fonc.2016.00240 · Cited by 35
Hypoxia in Lung Cancer Management: A Translational Approach
Ancel, J., Perotin, J., Dewolf, M., Launois, C., Mulette, P., Nawrocki‐Raby, B., Dalstein, V., Gilles, C., Deslée, G., Polette, M., et al. (2021) · Cancers · doi:10.3390/cancers13143421 · Cited by 32
Resisting T cell attack: tumor-cell-intrinsic defense and reparation mechanisms
McKenzie, B., & Valitutti, S. (2022) · Trends in cancer · doi:10.1016/j.trecan.2022.12.003 · Cited by 33
Autophagy in Tumor Immunity
Amaravadi, R. K. (2011) · Science · doi:10.1126/science.1216428 · Cited by 34
Hypoxia augments MHC class I antigen presentation via facilitation of ERO1‐α‐mediated oxidative folding in murine tumor cells
Kajiwara, T., Tanaka, T., Kukita, K., Kutomi, G., Saito, K., Okuya, K., Takaya, A., Kochin, V., Kanaseki, T., Tsukahara, T., et al. (2016) · European Journal of Immunology · doi:10.1002/eji.201646525 · Cited by 31
The human cathelicidin peptide LL-37 inhibits pancreatic cancer growth by suppressing autophagy and reprogramming of the tumor immune microenvironment
Zhang, Z., Chen, W., Zhang, S., Bai, J., Lau, C.-L., Sze, S. C. W., Yung, K. K. L., & Ko, J. K.-S. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.906625 · Cited by 33
Autophagy: A boon or bane in oral cancer
Adhauliya, N., Kalappanavar, A. N., Ali, I., & Annigeri, R. G. (2016) · Oral Oncology · doi:10.1016/j.oraloncology.2016.09.001 · Cited by 31
Chemokine Receptors and Exercise to Tackle the Inadequacy of T Cell Homing to the Tumor Site
Idorn, M., & Straten, P. T. (2018) · Cells · doi:10.3390/cells7080108 · Cited by 34
Firing up the cold tumors by targeting Vps34
Janji, B., Hasmim, M., Parpal, S., Berchem, G., & Noman, M. Z. (2020) · OncoImmunology · doi:10.1080/2162402x.2020.1809936 · Cited by 30
“Additionally, we showed that targeting autophagy improved the efficacy of cancer vaccination and promoted tumor regression in melanoma.(3) We further revealed that silencing the autophagy-related protein Beclin1 decreased tumor growth by inducing a massive infiltration of NK cells through the release of CCL5/RANTES by…”
BackgroundSelf-citation
Inhibition of autophagy-related protein 7 enhances anti-tumor immune response and improves efficacy of immune checkpoint blockade in microsatellite instability colorectal cancer
Zhang, W., Chen, L., Liu, J., Chen, B., Shi, H., Chen, H., Qi, H., Wu, Z., Mao, X., Wang, X., et al. (2024) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-024-03023-w · Cited by 30
MicroRNAs and Tumor Vasculature Normalization: Impact on Anti-Tumor Immune Response
Matejuk, A., Collet, G., Nadim, M., Grillon, C., & Kiéda, C. (2013) · Archivum Immunologiae et Therapiae Experimentalis · doi:10.1007/s00005-013-0231-4 · Cited by 30
Hijacker of the Antitumor Immune Response: Autophagy Is Showing Its Worst Facet
Viry, E., Noman, M. Z., Arakelian, T., Lequeux, A., Chouaı̈b, S., Berchem, G., Moussay, E., Paggetti, J., & Janji, B. (2016) · Frontiers in Oncology · doi:10.3389/fonc.2016.00246 · Cited by 31
Self-citation
Unfolding the role of autophagy in the cancer metabolism
Pandey, A., Yadav, P., & Shukla, S. (2021) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2021.101158 · Cited by 31
Positron emission tomography imaging sheds new light on hypoxia and antitumor therapies
Fang, H., Wang, X., Lan, X., & Jiang, D. (2023) · Interdisciplinary medicine · doi:10.1002/inmd.20230002 · Cited by 29
Inhibiting Autophagy
Lotze, M. T., Maranchie, J. K., & Appleman, L. J. (2013) · The Cancer Journal · doi:10.1097/ppo.0b013e31829da0d6 · Cited by 31
The Role of Phosphatidylinositol 3-Kinase Catalytic Subunit Type 3 in the Pathogenesis of Human Cancer
Chu, C., Wang, Y.-W., Chen, Y.-L., Chen, H., Chuang, J.-J., Chang, H., Ho, C., Chang, C., Chow, N.-H., & Lee, C. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222010964 · Cited by 31
Anti-tumor immunity influences cancer cell reliance upon ATG7
Arensman, M. D., Yang, X. S., Zhong, W., Bisulco, S., Upeslacis, E., Rosfjord, E. C., Deng, S., Abraham, R. T., & Eng, C. H. (2020) · OncoImmunology · doi:10.1080/2162402x.2020.1800162 · Cited by 27
An Updated Review on Implications of Autophagy and Apoptosis in Tumorigenesis: Possible Alterations in Autophagy through Engineered Nanomaterials and Their Importance in Cancer Therapy
Ghaznavi, H., Shirvaliloo, M., Zarebkohan, A., Shams, Z., Radnia, F., Bahmanpour, Z., Sargazi, S., Saravani, R., Shirvalilou, S., Shahraki, O., et al. (2021) · Molecular Pharmacology · doi:10.1124/molpharm.121.000234 · Cited by 27
Greek Fire, Poison Arrows, and Scorpion Bombs: How Tumor Cells Defend Against the Siege Weapons of Cytotoxic T Lymphocytes
McKenzie, B., Khazen, R., & Valitutti, S. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.894306 · Cited by 27
AMPK-independent autophagy promotes radioresistance of human tumor cells under clinical relevant hypoxia in vitro
Chaachouay, H., Fehrenbacher, B., Toulany, M., Schaller, M., Multhoff, G., & Rodemann, H. P. (2015) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2015.08.012 · Cited by 26
Autophagy therapeutics: preclinical basis and initial clinical studies
Zhan, L., Li, J., & Wei, B. (2018) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-018-3688-3 · Cited by 25
How Cells Communicate with Each Other in the Tumor Microenvironment: Suggestions to Design Novel Therapeutic Strategies in Cancer Disease
Zefferino, R., Piccoli, C., Gioia, S. D., Capitanio, N., & Conese, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22052550 · Cited by 26
Autophagy-modulating biomembrane nanostructures: A robust anticancer weapon by modulating the inner and outer cancer environment
Zhang, X., Zhang, M., Cui, H., Zhang, T., Wu, L., Xu, C., Yin, C., & Gao, J. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.12.032 · Cited by 25
Expression of EPHRIN-A1, SCINDERIN and MHC class I molecules in head and neck cancers and relationship with the prognostic value of intratumoral CD8+T cells
Hasmim, M., Badoual, C., Vielh, P. R., Drusch, F., Marty, V., Laplanche, A., Diniz, M. O., Roussel, H., Guillebon, É. D., Oudard, S. M., et al. (2013) · BMC Cancer · doi:10.1186/1471-2407-13-592 · Cited by 23
Glutamine is essential for overcoming the immunosuppressive microenvironment in malignant salivary gland tumors
Cao, S., Hung, Y., Wang, Y.-C., Chung, Y., Qi, Y., Ouyang, C., Zhong, X., Hu, W., Coblentz, A., Maghami, E. G., et al. (2022) · Theranostics · doi:10.7150/thno.73896 · Cited by 25
Do Tumor Mechanical Stresses Promote Cancer Immune Escape?
Onwudiwe, K. C., Najera, J., Siri, S., & Datta, M. (2022) · Cells · doi:10.3390/cells11233840 · Cited by 22
Exploiting autophagy balance in T and NK cells as a new strategy to implement adoptive cell therapies
Giansanti, M., Theinert, T., Boeing, S. K., Haas, D., Schlegel, P., Vacca, P., Nazio, F., & Caruana, I. (2023) · Molecular Cancer · doi:10.1186/s12943-023-01893-w · Cited by 24
The gluttonous side of malignant melanoma: basic and clinical implications of macroautophagy
Chęcińska, A., & Soengas, M. S. (2011) · Pigment Cell & Melanoma Research · doi:10.1111/j.1755-148x.2011.00927.x · Cited by 23
The Multifaceted Effects of Autophagy on the Tumor Microenvironment
Kang, R., Zeh, H. J., Lotze, M. T., & Tang, D. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-35727-6_7 · Cited by 22
Plasma, cancer, immunity
Bekeschus, S., & Clemen, R. (2022) · Journal of Physics D Applied Physics · doi:10.1088/1361-6463/ac9398 · Cited by 22
CCDC50 promotes tumor growth through regulation of lysosome homeostasis
Jia, P., Tian, T., Li, Z., Wang, Y., Lin, Y., Zeng, W., Ye, Y., He, M., Ni, X., Pan, J., et al. (2023) · EMBO Reports · doi:10.15252/embr.202356948 · Cited by 20
A risk signature of three autophagy-related genes for predicting lower grade glioma survival is associated with tumor immune microenvironment
Lin, J., & Lin, N. (2020) · Genomics · doi:10.1016/j.ygeno.2020.10.008 · Cited by 20
Cell-associated galectin 9 interacts with cytotoxic T cells confers resistance to tumor killing in nasopharyngeal carcinoma through autophagy activation
Kam, N., Lau, C. Y., Lau, J. Y. H., Dai, X., Liang, Y., Lai, S. P. H., Chung, M. K. Y., Yu, V. Z., Qiu, W., Yang, M., et al. (2025) · Cellular and Molecular Immunology · doi:10.1038/s41423-024-01253-8 · Cited by 19
Role of Autophagy in Cancer and Tumor Progression
Janji, B., Viry, E., Bagińska, J., Van, K. T., & Berchem, G. (2013) · InTech eBooks · doi:10.5772/55388 · Cited by 19
Self-citation
Fasting-Mimicking Diet Inhibits Autophagy and Synergizes with Chemotherapy to Promote T-Cell-Dependent Leukemia-Free Survival
Buono, R., Tucci, J., Cutri, R. M., Guidi, N., Mangul, S., Raucci, F., Pellegrini, M. A., Mittelman, S. D., & Longo, V. D. (2023) · Cancers · doi:10.3390/cancers15245870 · Cited by 19
The Role of Metabolism in Tumor Immune Evasion: Novel Approaches to Improve Immunotherapy
Cruz‐Bermúdez, A., Briviesca, R. L., Casarrubios, M., Sierra‐Rodero, B., & Provencio, M. (2021) · Biomedicines · doi:10.3390/biomedicines9040361 · Cited by 20
Lucanthone Targets Lysosomes to Perturb Glioma Proliferation, Chemoresistance and Stemness, and Slows Tumor Growth In Vivo
Radin, D. P., Smith, G. T., Moushiaveshi, V., Wolf, A., Bases, R. E., & Tsirka, S. E. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.852940 · Cited by 18
AC ‐1001 H3 CDR peptide induces apoptosis and signs of autophagy in vitro and exhibits antimetastatic activity in a syngeneic melanoma model
Rabaça, A. N., Arruda, D. C., Figueiredo, C. R., Massaoka, M. H., Farias, C. F., Tada, D. B., Maia, V., Silva, P. I., Girola, N., Real, F., et al. (2016) · FEBS Open Bio · doi:10.1002/2211-5463.12080 · Cited by 20
Metabolic rewiring directs melanoma immunology
Sun, N., Tian, Y., Chen, Y., Guo, W., & Li, C. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.909580 · Cited by 19
Autophagy in BRAF-mutant cutaneous melanoma: recent advances and therapeutic perspective
Fratta, E., Giurato, G., Guerrieri, R., Colizzi, F., Col, J. D., Weisz, A., Steffan, A., & Montico, B. (2023) · Cell Death Discovery · doi:10.1038/s41420-023-01496-w · Cited by 17
Chloroquine enhanced the anticancer capacity of VNP20009 by inhibiting autophagy
Zhang, X., Xu, Q., Zhang, Z., Cheng, W., Cao, W., Jiang, C., Han, C., Li, J., & Hua, Z. (2016) · Scientific Reports · doi:10.1038/srep29774 · Cited by 17
Autophagy Modulation by Viral Infections Influences Tumor Development
Leonardi, L., Sibéril, S., Alifano, M., Cremer, I., & Joubert, P.-E. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.743780 · Cited by 16
The Promise of Targeting Hypoxia to Improve Cancer Immunotherapy: Mirage or Reality?
Janji, B., & Chouaı̈b, S. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.880810 · Cited by 18
Self-citation
Crosstalk between autophagy and immune cell infiltration in the tumor microenvironment
Yang, T., Zhang, Y., Chen, J., & Sun, L. (2023) · Frontiers in Medicine · doi:10.3389/fmed.2023.1125692 · Cited by 17
Mechanisms of HIF-driven immunosuppression in tumour microenvironment
Bandopadhyay, S., & Patranabis, S. (2023) · Journal of the Egyptian National Cancer Institute · doi:10.1186/s43046-023-00186-z · Cited by 20
Visualized photodynamic nanomaterials activating tumor-associated immune landscape as a next-generation anticancer strategy
Tian, L., Li, X., Guo, L., Huang, L., Wu, X., & Gao, W. (2024) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2024.216027 · Cited by 16
Vps34 sustains Treg cell survival and function via regulating intracellular redox homeostasis
Feng, P., Yang, Q., Luo, L., Guan, Z., Fu, J., Zhao, M., Meng, W., Wan, S., He, J., Li, Z., et al. (2024) · Cell Death and Differentiation · doi:10.1038/s41418-024-01353-y · Cited by 17
Multimodality Approaches to Treat Hypoxic Non-Small Cell Lung Cancer (NSCLC) Microenvironment
Liang, S., Galluzzo, P., Sobol, A., Skucha, S., Rambo, B., & Bocchetta, M. (2012) · Genes & Cancer · doi:10.1177/1947601912457025 · Cited by 16
BRCA1/2 Mutation Status Impact on Autophagy and Immune Response: Unheralded Target
Morand, S. M., Stanbery, L., Walter, A., Rocconi, R. P., & Nemunaitis, J. J. (2020) · JNCI Cancer Spectrum · doi:10.1093/jncics/pkaa077 · Cited by 17
Combining VPS34 inhibitors with STING agonists enhances type I interferon signaling and anti‐tumor efficacy
Yu, Y., Jagannathan‐Bogdan, M., Noman, M. Z., Parpal, S., Bartolini, E., Moer, K. V., Kleinendorst, S. C., Sæther, K. B., Tresaugues, L., Silvander, C., et al. (2024) · Molecular Oncology · doi:10.1002/1878-0261.13619 · Cited by 14
Self-citation
Autophagy-Associated Immunogenic Modulation and Its Applications in Cancer Therapy
Duan, Z., Shi, Y., Lin, Q., Hamaï, A., Mehrpour, M., & Gong, C. (2022) · Cells · doi:10.3390/cells11152324 · Cited by 16
Enhancing Therapeutic Efficacy in Cancer Treatment: Integrating Nanomedicine with Autophagy Inhibition Strategies
Walweel, N., & Aydin, Ö. F. (2024) · ACS Omega · doi:10.1021/acsomega.4c02234 · Cited by 15
Distinct subgroup of the Ras family member 3 (DIRAS3) expression impairs metastasis and induces autophagy of gastric cancer cells in mice
Qiu, J., Li, X.-T., He, Y., Sun, D., Li, W., & Yan, X. (2018) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-018-2708-3 · Cited by 14
Associations between HIFs and tumor immune checkpoints: mechanism and therapy
Liu, J., Jiang, Y., Chen, L., Qian, Z., & Zhang, Y. (2024) · Discover Oncology · doi:10.1007/s12672-023-00836-7 · Cited by 13
The Role and Therapeutic Potential of Autophagy Modulation in Controlling Virus‐Induced Cell Death
Tovilović-Kovačević, G., Ristic, B. Z., Milenkovic, M. M., Stanojević, M., & Trajković, V. (2013) · Medicinal Research Reviews · doi:10.1002/med.21303 · Cited by 13
Targeting endocytosis to sensitize cancer cells to programmed cell death
Chan, E. T., & Kural, C. (2024) · Biochemical Society Transactions · doi:10.1042/bst20231332 · Cited by 12
Nanoformula Design for Inducing Non‐Apoptotic Cell Death Regulation: A Powerful Booster for Cancer Immunotherapy
Hu, Y., Yu, Q., Li, X., Wang, J., Guo, L., Huang, L., & Gao, W. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202403493 · Cited by 13
Hypoxia-inducing factor (HIF)-1α-derived peptide capable of inducing cancer-reactive cytotoxic T lymphocytes from HLA-A24+ patients with renal cell carcinoma
Minami, T., Matsumura, N., Sugimoto, K., Shimizu, N., Velasco, M. A. D., Nozawa, M., Yoshimura, K., Harashima, N., Harada, M., & Uemura, H. (2017) · International Immunopharmacology · doi:10.1016/j.intimp.2017.01.014 · Cited by 12
Autophagic cell death participates in POMC-induced melanoma suppression
Wu, J., Tsai, H., Liu, G., Wu, C., & Tai, M. (2018) · Cell Death Discovery · doi:10.1038/s41420-018-0070-5 · Cited by 12
Identification of Immune-Related Breast Cancer Chemotherapy Resistance Genes via Bioinformatics Approaches
Du, Y., Han, Y., Wang, X., Wang, H., Qu, Y., Guo, K., Ma, W., & Fu, L. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.772723 · Cited by 9
From Intestinal Epithelial Homeostasis to Colorectal Cancer: Autophagy Regulation in Cellular Stress
Liu, Q.-L., Chen, Y., Zhou, L., Chen, H., & Zhou, Z. (2022) · Antioxidants · doi:10.3390/antiox11071308 · Cited by 9
Low expression of HIF1AN accompanied by less immune infiltration is associated with poor prognosis in breast cancer
Tang, S., Liu, D., Fang, Y., Yong, L., Zhang, Y., Guan, M., Lin, X., Wang, H., & Cai, F. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1080910 · Cited by 9
Autophagy modulation in cancer
Guilbaud, E., Ryan, K. M., Green, D. R., & Galluzzi, L. (2026) · Nature Reviews Drug Discovery · doi:10.1038/s41573-026-01449-9 · Cited by 11
Genomic Analysis of Waterpipe Smoke-Induced Lung Tumor Autophagy and Plasticity
Zaarour, R. F., Sharda, M., Azakir, B., Venkatesh, G. H., Khouzam, R. A., Rifath, A., Nizami, Z. N., Abdullah, F., Mohammad, F., Karaali, H., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23126848 · Cited by 8
CD8+ T cell metabolic changes in breast cancer
Castoldi, Â., Lee, J., Carvalho, D. D. S., & Souto, F. O. (2022) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2022.166565 · Cited by 9
The dual role of autophagy in HPV-positive head and neck squamous cell carcinoma: a systematic review
Kandathil, S. A., Akhondi, A., Kadletz‐Wanke, L., Heiduschka, G., Engedal, N., & Brkic, F. F. (2024) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-023-05514-3 · Cited by 7
Leptin decreases BC cell susceptibility to NK lysis via PGC1A pathway
Bouguerra, H., Amal, G., Clavel, S., Boussen, H., Louet, J., & Gati, A. (2020) · Endocrine Connections · doi:10.1530/ec-20-0109 · Cited by 7
Targeting the stress support network regulated by autophagy and senescence for cancer treatment
Kim, J., Lee, Y., Roh, K., Kim, M.-S., & Kang, C. (2021) · Advances in cancer research · doi:10.1016/bs.acr.2021.01.003 · Cited by 7

Authors: Noman, M. Z., Janji, B., Kaminska, B., Van Moer, K., Pierson, S., Przanowski, P., Buart, S., Berchem, G., Romero, P., Mami-Chouaib, F., & Chouaib, S.
Affiliations: Inserm (FR)
Authors' Affiliations: 1Unité INSERM U753, Institut de Cancérologie Gustave Roussy, Villejuif Cedex, France; 2Laboratory of Experimental Hemato-Oncology, Department of Oncology, Public Research Center for Health (CRP-Santé), Luxembourg City, Luxembourg; 3Laboratory of Transcription Regulation, Department of Cell Biology, Nencki Institute, Warsaw, Poland; and 4Translational Tumor Immunology group, Ludwig Center for Cancer Research, University of Lausanne, Lausanne, Switzerland
ORCID: Noman, Muhammad Zaeem
Janji, Bassam
Przanowski, Piotr
Buart, Stéphanie
Berchem, Guy
Romero, Pedro
Venue: Cancer Research
Publisher: American Association for Cancer Research (AACR)
Published: 2011-09-13
Volume: 71
Issue: 18
Pages: 5976-5986
ISSN: 0008-5472 (ISSN-L)
1538-7445
DOI: 10.1158/0008-5472.can-11-1094
OpenAlex: W2151713424
Cited by: 256
References: 44
Citations by year: 2026: 8 · 2025: 2 · 2024: 15 · 2023: 15 · 2022: 30 · 2021: 30 · 2020: 24 · 2019: 16 · 2018: 16 · 2017: 16 · 2016: 23 · 2015: 11 · 2014: 14 · 2013: 19 · 2012: 12
FWCI: 12.00
Type: journal article
Language: en
Open access: closed
Locations: Cancer Research (publishedVersion)
PubMed (publishedVersion)
IRIS (submittedVersion)
SERVAL (Université de Lausanne) (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
Keywords: tumor hypoxia, autophagy, cytotoxic T lymphocytes, STAT3 phosphorylation, HIF-1α, Beclin-1, ATG5, Src kinase, ubiquitin-proteasome system, p62, tumor regression, B16F10 melanoma, hydroxychloroquine, tumor immunology
MeSH terms: Sequestosome-1 Protein, Animals, Autophagy, Heat-Shock Proteins, Humans, Lung Neoplasms, Melanoma, Experimental, Mice, Inbred C57BL, Phosphorylation, T-Lymphocytes, Cytotoxic, Cell Hypoxia, src-Family Kinases, Ubiquitin, Cell Line, Tumor, Proteasome Endopeptidase Complex, Adaptor Proteins, Signal Transducing, STAT3 Transcription Factor, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Blocking Hypoxia-Induced Autophagy in Tumors Restores Cytotoxic T-Cell Activity and Promotes Regression

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks