Mechanisms of Ploidy Increase in Human Cancers: A New Role for Cell Cannibalism
Open accessAbstract
Aneuploidy is a hallmark of human cancers originating from abnormal mitoses. Many aneuploid cancer cells also have greater-than-diploid DNA content, suggesting that polyploidy is a common precursor to aneuploidy during tumor progression. Polyploid cells can originate from cell fusion, endoreplication, and cytokinesis failure. Recently we found that cell cannibalism by entosis, a form of cell engulfment involving live cells, also leads to polyploidy, as internalized cells disrupt cytokinesis of their engulfing cell hosts. By this mechanism, cannibalistic cell behavior could promote tumor progression by leading to aneuploidy. Here, we discuss cell cannibalism in cancer and other mechanisms that result in the formation of polyploid cancer cells. Cancer Res; 72(7); 1596–601. ©2012 AACR.
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Entotic invasion has been suggested to favor aneuploidization and polyploidization through cytokinesis failure of engulfing cells.
“entotic invasion has also been suggested to favor aneuploidization and polyploidization (which promote tumor progression) [711–713] through a mechanism involving cytokinesis failure of engulfing cells [714, 715].”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [715]
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References 34 · Cited by 102
- Authors
- Krajcovic, M., & Overholtzer, M.
- Affiliations
- Memorial Sloan Kettering Cancer Center (US)
- Corresponding author
- Overholtzer, Michael
- ORCID
- Overholtzer, Michael
- Venue
- Cancer Research
- Published
- 2012-04-01
- Volume
- 72
- Issue
- 7
- Pages
- 1596-1601
- ISSN
- 0008-5472 (ISSN-L)
- 1538-7445
- PMC
- PMC3319989
- OpenAlex
- W2145393673
- Cited by
- 102
- References
- 34
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 9 · 2023: 4 · 2022: 3 · 2021: 11 · 2020: 6 · 2019: 9 · 2018: 10 · 2017: 5 · 2016: 10 · 2015: 7 · 2014: 10 · 2013: 9 · 2012: 2
- FWCI
- 0.82
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cancer Research (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (R01CA154649)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Keywords
- polyploidy, aneuploidy, entosis, cell cannibalism, cell fusion, endoreplication, cytokinesis failure, tumor progression, abnormal mitosis
- MeSH terms
- Animals, Cell Fusion, Humans, Neoplasms, Polyploidy, Telomere, Disease Progression, Cytokinesis, Entosis, Cytophagocytosis
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