An Antibody–Drug Conjugate That Targets Tissue Factor Exhibits Potent Therapeutic Activity against a Broad Range of Solid Tumors

Breij, Esther C.W.; de Goeij, Bart E.C.G.; Verploegen, Sandra; Schuurhuis, Danita H.; Amirkhosravi, Ali; Francis, John; Miller, Vibeke Breinholt; Houtkamp, Mischa; Bleeker, Wim K.; Satijn, David; Parren, Paul W.H.I.

doi:10.1158/0008-5472.can-13-2440

An Antibody–Drug Conjugate That Targets Tissue Factor Exhibits Potent Therapeutic Activity against a Broad Range of Solid Tumors

Tissue factor (TF) is aberrantly expressed in solid cancers and is thought to contribute to disease progression through its procoagulant activity and its capacity to induce intracellular signaling in complex with factor VIIa (FVIIa). To explore the possibility of using tissue factor as a target f…