Fatty Acid-Binding Protein E-FABP Restricts Tumor Growth by Promoting IFN-β Responses in Tumor-Associated Macrophages
Open accessPublished version of a preprint
Abstract
Fatty acid-binding proteins (FABP) are known central regulators of both metabolic and inflammatory pathways, but their role in tumor development remains largely unexplored. Here, we report that host expression of epidermal FABP (E-FABP) protects against mammary tumor growth. We find that E-FABP is highly expressed in macrophages, particularly in a specific subset, promoting their antitumor activity. In the tumor stroma, E-FABP–expressing tumor-associated macrophages (TAM) produce high levels of IFN-β through upregulation of lipid droplet formation in response to tumors. E-FABP–mediated IFN-β signaling can further enhance recruitment of tumoricidal effector cells, in particular natural killer cells, to the tumor stroma for antitumor activity. These findings identify E-FABP as a new protective factor to strengthen IFN-β responses against tumor growth. Cancer Res; 74(11); 2986–98. ©2014 AACR.
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References 49 · Cited by 129
- Authors
- Zhang, Y., Sun, Y., Rao, E., Yan, F., Li, Q., Zhang, Y., Silverstein, K. A. T., Liu, S., Sauter, E., Cleary, M. P., & Li, B.
- Affiliations
- University of Minnesota (US)
- Corresponding author
- Li, Bing
- ORCID
- Venue
- Cancer Research
- Published
- 2014-05-29
- Volume
- 74
- Issue
- 11
- Pages
- 2986-2998
- ISSN
- 0008-5472 (ISSN-L)
- 1538-7445
- PMC
- PMC4040301
- OpenAlex
- W2015671992
- Semantic Scholar
- 9450d25f8ad5d49f3e12cfcef499513cc9853fc4
- Cited by
- 129
- References
- 49
- Citations by year
- 2026: 5 · 2025: 10 · 2024: 17 · 2023: 13 · 2022: 15 · 2021: 18 · 2020: 18 · 2019: 6 · 2018: 8 · 2017: 6 · 2016: 3 · 2015: 8 · 2014: 2
- FWCI
- 2.89
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Cancer Research (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Mayo Clinic
- National Cancer Institute (R01CA157012)
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK050456)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Keywords
- tumor-associated macrophages, interferon-beta, mammary tumor growth, lipid droplet formation, natural killer cells, antitumor immunity, tumor stroma
- MeSH terms
- Animals, Epidermis, Female, Humans, Killer Cells, Natural, Lipids, Macrophages, Mammary Neoplasms, Experimental, Mice, Inbred C57BL, Tumor Cells, Cultured, Gene Expression, Interferon-beta, Fatty Acid-Binding Proteins, Mice
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