Potent and selective PTDSS1 inhibitors induce collateral lethality in cancers with PTDSS2 deletion

Yoshihama, Yohei; Namiki, Hidenori; Kato, Taiga; Shimazaki, Naomi; Takaishi, Sachiko; Kadoshima-Yamaoka, Kumiko; Yukinaga, Hideo; Maeda, Naoyuki; Shibutani, Tomoko; Fujimoto, Kazunori; Hirasawa, Makoto; Goto, Hiroki; Wada, Naoya; Tsutsumi, Shinji; Hirota, Yasuhide; Ishikawa, Tomoki; Yamamoto, Shoji

doi:10.1158/0008-5472.can-22-1006

Potent and selective PTDSS1 inhibitors induce collateral lethality in cancers with PTDSS2 deletion

Significance This study identifies a specific dependency on PTDSS1 for phosphatidylserine synthesis following PTDSS2 deletion and introduces novel PTDSS1 inhibitors as a therapeutic option to induce collateral lethality in cancer with PTDSS2 loss.