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Prior Hospitalization for Epilepsy, Diabetes, and Stroke and Subsequent Glioma and Meningioma Risk
Abstract
We conducted a case-control study to evaluate the preclinical association between epilepsy, diabetes, and stroke and primary adult brain tumors. We first identified all 1,501 low-grade glioma, 4,587 high-grade glioma (HGG), and 4,193 meningioma cases reported to the Swedish Cancer Registry from 1987 to 1999. Next, controls (137,485) were randomly selected from the continuously updated Swedish Population Registry and matched to cases diagnosed that year on age and sex. Finally, cases and controls were linked to the Swedish Hospital Discharge Registry (1969-1999). We found that ≥8 years before HGG diagnosis (or control reference year) there was an elevated risk of HGG among people discharged with epilepsy [odds ratio (OR), 3.01; 95% confidence interval (95% CI), 1.73-5.22]. Two to 3 years before HGG diagnosis, this risk increased (OR, 5.33; 95% CI, 3.58-7.93) and was especially strong among people ages <55 years (OR, 13.49; 95% CI, 6.99-25.94). During this 2- to 3-year prediagnostic period, we also found an increased risk of HGG among people discharged with meningitis (OR, 3.02; 95% CI, 1.06-8.59) or viral encephalitis (OR, 12.64; 95% CI, 2.24-71.24). Results are similar for glioblastoma multiforme, low-grade glioma, and meningioma. In contrast, risk of HGG among people discharged with diabetes or stroke does not increase until year of brain tumor diagnosis. The occurrence of excess epilepsy ≥8 years before HGG diagnosis suggests a relatively long preclinical phase, but excess diabetes or stroke appear late in HGG development.
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“Actually, in one Swedish study investigating the preclinical association between mobile phone use and primary adult intracranial tumours (Schwartzbaum et al., 2005), an increased risk of meningioma was observed among people discharged with epilepsy ≥ 11 years before the neoplasm diagnosis (OR 2.16; 95 % CI 1.45–3.21).”
From The effect of exposure to radiofrequency fields on cancer risk in the general and working population: A systematic review of human observational studies - Part I: Most researched outcomes. (2024) · cites this paper as Schwartzbaum et al., 2005
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Wideroff, L., Gridley, G., Chow, W. H., Linet, M., Mellemkjaer, L., Olsen, J. H., Keehn, S., & Borch-Johnsen, K. (1997) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/89.18.1360 · Cited by 627 · cited 2×
“In contrast to the positive association with epilepsy and glioma, an inverse association between diabetes and glioma has been observed previously in two studies (7, 8) but not in four others (1, 9-11).”
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Karipidis, K., Baaken, D., Loney, T., Blettner, M., Brzozek, C., Elwood, M., Narh, C., Orsini, N., Röösli, M., Paulo, M. S., et al. (2024) · Environment International · doi:10.1016/j.envint.2024.108983 · Cited by 58
Metadata
- Authors
- Schwartzbaum, J., Jonsson, F., Ahlbom, A., Preston-Martin, S., Malmer, B., Lönn, S., Söderberg, K., & Feychting, M.
- Affiliations
- 1Division of Epidemiology and Biometrics, School of Public Health, Ohio State University, Columbus, Ohio;
- 2Division of Epidemiology, Institute for Environmental Medicine, Karolinska Institutet, Stockholm, Sweden;
- 3University of Southern California School of Medicine, Los Angeles, California; and
- 4Department of Radiation Sciences, Oncology, Umeå University Hospital, Umeå, Sweden
- Venue
- Cancer Epidemiology, Biomarkers & Prevention
- Published
- 2005-03-01
- Volume
- 14
- Issue
- 3
- Pages
- 643-650
- ISSN
- 1055-9965
- 1538-7755
- Cited by
- 56
- References
- 1
- Language
- en
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- Schwartzbaum, J., Jonsson, F., Ahlbom, A., Preston-Martin, S., Malmer, B., Lönn, S., Söderberg, K., & Feychting, M. (2005). Prior Hospitalization for Epilepsy, Diabetes, and Stroke and Subsequent Glioma and Meningioma Risk. Cancer Epidemiology, Biomarkers & Prevention. https://doi.org/10.1158/1055-9965.epi-04-0119
