Cited by 118Pharmacogenetics and Drug MetabolismEstrogen and related hormone effectsMetal-Catalyzed Oxygenation Mechanisms

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Role of Polymorphic Human Cytochrome P450 Enzymes in Estrone Oxidation

Cribb, Alastair E., Knight, M. Joy, Dryer, Dagny, Guernsey, Judy, Hender, Kimberly, Tesch, Marvin, Saleh, Tarek M.·2006·Cancer Epidemiology, Biomarkers & Prevention

DOI 10.1158/1055-9965.epi-05-0801

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Abstract

Estrogen and its metabolites are believed to play important roles in breast cancer. The influence of genetic polymorphisms in the enzymes responsible for formation and disposition of estrogen on breast cancer risk may shed light on the importance of estrogen metabolites in this disease. However, for such studies to be valid, it is important to correctly identify the enzymes involved in estrogen bioactivation. Therefore, we assessed the human cytochrome P450-dependent oxidation of estrone using substrate concentrations that more closely approximate the maximum expected concentrations in breast tissue. The in vitro metabolism of estrone by recombinant human cytochrome P450 enzymes and human liver microsomes was studied. The formation of estrone metabolites (2-hydroxyestrone, 4-hydroxyestrone, and 16alpha-hydroxyestrone) was monitored by high-performance liquid chromatography. 2-Hydroxyestrone formation was catalyzed predominantly by CYP1A2, CYP1A1, and CYP1B1 enzymes; 4-hydroxyestrone formation was catalyzed predominantly by CYP1B1, CYP1A2, and CYP1A1 enzymes; and 16alpha-hydroxyestrone formation was catalyzed predominantly by CYP2C19, CYP1A1, and CYP3A5. This study confirms the important role of members of the CYP1 family in the 2-hydroxylation and 4-hydroxylation of estrone, but the enzymes identified as responsible for the 16alpha-hydroxylation of estrone are different from those previously identified. The relative importance of these enzymes in vivo would depend on the specific tissue expression of the enzymes. These enzymes are all known to be genetically variant in the human population, and additional studies to assess the role CYP1A2, CYP2C19, and CYP3A5 in breast cancer risk are indicated.

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Authors: Cribb, A. E., Knight, M. J., Dryer, D., Guernsey, J., Hender, K., Tesch, M., & Saleh, T. M.
Affiliations: University of Prince Edward Island (CA)
2Queen Elizabeth Hospital, Charlottetown, Prince Edward Island, Canada; and
Dalhousie University (CA)
ORCID: Cribb, Alastair E.
Saleh, Tarek M.
Venue: Cancer Epidemiology, Biomarkers & Prevention
Publisher: American Association for Cancer Research (AACR)
Published: 2006-03-01
Volume: 15
Issue: 3
Pages: 551-558
ISSN: 1055-9965 (ISSN-L)
1538-7755
DOI: 10.1158/1055-9965.epi-05-0801
OpenAlex: W2141239229
Cited by: 118
References: 70
Citations by year: 2025: 3 · 2024: 5 · 2023: 8 · 2022: 7 · 2021: 6 · 2020: 3 · 2019: 6 · 2018: 3 · 2017: 4 · 2016: 2 · 2015: 5 · 2014: 8 · 2013: 7 · 2012: 8
FWCI: 7.31
Type: journal article
Language: en
Open access: closed
Locations: Cancer Epidemiology Biomarkers & Prevention (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
Physical Sciences › Chemistry › Inorganic Chemistry › Metal-Catalyzed Oxygenation Mechanisms
Keywords: estrogen metabolism, cytochrome P450 polymorphisms, breast cancer risk, 2-hydroxyestrone, 4-hydroxyestrone, 16α-hydroxyestrone, CYP1A2, CYP1A1, CYP1B1, CYP2C19, CYP3A5, liver microsomes, genetic variation
MeSH terms: Breast Neoplasms, Chromatography, High Pressure Liquid, Cytochrome P-450 Enzyme System, Estrone, Female, Humans, Mixed Function Oxygenases, Hydroxylation, Microsomes, Liver, Oxidation-Reduction, Sensitivity and Specificity, Tumor Cells, Cultured, Biomarkers, Tumor, Cytochrome P-450 CYP1A1, Cytochrome P-450 CYP1A2, In Vitro Techniques

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Role of Polymorphic Human Cytochrome P450 Enzymes in Estrone Oxidation

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