Human Papillomavirus-16 Modifies the Association between Fruit Consumption and Head and Neck Squamous Cell Carcinoma
Open accessAbstract
Human papillomavirus-16 (HPV-16) is a risk factor for head and neck squamous cell carcinoma (HNSCC). HPV-positive cancers have distinct disease cofactors and improved survival following treatment. There is conflicting evidence of a protective association of fruit consumption with HNSCC. As HPV-related disease is clinically distinct, we investigated whether the association between fruit consumption and HNSCC risk was modified by exposure to HPV-16. We studied 270 cases and 493 controls with fruit intake information and known HPV-16 antibody status. Cases were identified at nine Boston-area medical facilities between 1999 and 2003. Controls were randomly selected from the greater population and frequency matched to cases by age, gender, and town of residence. Controlling for age, gender, race, smoking, alcohol, total energy intake, body mass index, and education, the seronegative individuals had a significantly lower risk of HNSCC with increasing total fruit consumption [odds ratio (OR)tertile 2, 0.60; 95% confidence interval (95% CI), 0.38-0.95; ORtertile 3, 0.57; 95% CI, 0.35-0.95] and specifically increasing citrus fruit consumption (ORtertile 2, 0.61; 95% CI, 0.39-0.97; ORtertile 3, 0.59; 95% CI, 0.37-0.96). However, among the seropositive, risk increased with greater fruit consumption (ORtertile 2, 2.27; 95% CI, 0.92-5.58; ORtertile 3, 1.40; 95% CI, 0.55-3.59) and citrus fruit consumption (ORtertile 2, 3.35; 95% CI, 1.36, 8.24; ORtertile 3, 3.15; 95% CI, 1.23-8.08). This interaction was statistically significant (P < 0.05), showing that fruit consumption was associated with a reduced HNSCC risk among HPV-16-seronegative individuals but an increased HNSCC risk among the HPV-16-seropositive individuals. These findings suggest that dietary factors dramatically alter the pattern of occurrence of HPV-associated HNSCC and show that viral-related disease is clinically and etiologically distinct. (Cancer Epidemiol Biomarkers Prev 2008;17(12):3419–26)
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Periodontitis is also associated with increased risk of oral squamous cell carcinoma.
“Periodontitis is also associated with increased risk of oral squamous cell carcinoma.214, 215”
From The oral microbiome: Role of key organisms and complex networks in oral health and disease (2021) · cites this paper as [214]
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References 55 · Cited by 27
Research works printed but not linked: 1
- [41]Willett W Nutritional Epidemiology Monographs in epidemiology and biostatistics 1998 v. 30 New York Oxford University Press
- Authors
- Meyer, M. S., Applebaum, K. M., Furniss, C. S., Peters, E. S., Luckett, B. G., Smith, J. F., Bryan, J., McClean, M. D., Marsit, C., & Kelsey, K. T.
- Affiliations
- 1Epidemiology, Departments of
- 2Environmental Health, and
- Harvard University (US)
- Louisiana State University (US)
- Merck & Co., Inc., Rahway, NJ, USA (United States) (US)
- Boston University (US)
- Brown University (US)
- ORCID
- Venue
- Cancer Epidemiology, Biomarkers & Prevention
- Published
- 2008-12-01
- Volume
- 17
- Issue
- 12
- Pages
- 3419-3426
- ISSN
- 1055-9965 (ISSN-L)
- 1538-7755
- PMC
- PMC3122126
- OpenAlex
- W2012965535
- Cited by
- 27
- References
- 55
- Citations by year
- 2024: 1 · 2023: 7 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 1 · 2015: 1 · 2014: 2 · 2013: 2 · 2012: 1
- FWCI
- 3.04
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by
- Locations
- Cancer Epidemiology Biomarkers & Prevention (publishedVersion, cc-by)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (T32 CA09001, CA 78609, CA100679, R01CA100679, R01CA078609, T32CA009001)
- National Institute for Occupational Safety and Health (K01 OH009390, OH 009390)
- Topics
- Health Sciences › Medicine › Otorhinolaryngology › Head and Neck Cancer Studies
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Medicine › Epidemiology › Cervical Cancer and HPV Research
- Keywords
- HPV16, head and neck squamous cell carcinoma, fruit consumption, citrus fruit, dietary risk factors, cancer risk modification, interaction effects, HPV-positive cancer
- MeSH terms
- Adult, Carcinoma, Squamous Cell, Diet, Female, Fruit, Head and Neck Neoplasms, Humans, Male, Surveys and Questionnaires, Logistic Models, Case-Control Studies, Human papillomavirus 16
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