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Rotating Night Shift Work and Risk of Ovarian Cancer
Open accessAbstract
Background: Night shift work has been associated with higher risks of breast and endometrial cancer, but few studies have evaluated associations with other reproductive cancers. Methods: We examined the association between rotating night shift work and risk of ovarian cancer during 20 years of follow-up in 181,548 women participating in two large cohort studies, the Nurses' Health Study (NHS) and NHSII. Number of years of rotating night shift work was queried in 1988 for NHS and in 1989, 1991, 1993, 2001, and 2005 for NHSII. We used Cox proportional hazards regression to model HRs and 95% CIs of ovarian cancer for each shift work category (1–2, 3–5, 6–9, 10–14, 15–19, and 20+ years). Results: We confirmed 718 incident cases of ovarian cancer over 2,974,672 person-years of follow-up. Rotating shift work was not associated with ovarian cancer risk in either cohort individually. Combining both cohorts, compared with women without any night work, the HR for 15 to 19 years of rotating night shift work was 1.28 (95% CI: 0.84–1.94) and for 20+ years 0.80 (95% CI: 0.51–1.23). Conclusions: In this large prospective study, there was no association between duration of rotating night shift work and risk of ovarian cancer. Impact: Although associated with other cancers, night shift work does not appear to be associated with increased risk of ovarian cancer. However, further exploration of the association between melatonin and risk of ovarian cancer is warranted. Cancer Epidemiol Biomarkers Prev; 20(5); 934–8. ©2011 AACR.
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Decrease of melatonin levels plays an important role in development of chronic diseases and conditions such as cancer, cardiovascular diseases, reproduction, endometriosis, gastrointestinal and digestive problems, diabetes, obesity, depression, sleep deprivation, bipolar spectrum disorders, and cognitive impairment.
“For instance, decrease of melatonin levels plays an important role in development of chronic diseases and conditions such as cancer 61, 80, 81, 82, 83, cardiovascular diseases 83, reproduction 84, endometriosis 84, gastrointestinal and digestive problems 85, diabetes 86, 87, obesity 88, depression 89, sleep deprivation 90, bipolar spectrum disorders 91, and cognitive impairment 92.”
From The inner clock-Blue light sets the human rhythm (2019) · cites this paper as [80]
The Introduction says diminished melatonin production may link night-shift work to cancer risk and describes possible anti-cancer effects of melatonin. That supports the cancer portion of the citing sentence, but not its stronger assertion that decreased melatonin plays an established, important role in cancer development. The Discussion reports no association between rotating night shifts and ovarian cancer in this study; the other listed conditions are cited to other sources. (LLM, conf=0.86)
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References 26 · Cited by 58
Metadata
- Authors
- Poole, E. M., Schernhammer, E. S., & Tworoger, S. S.
- Affiliations
- Brigham and Women's Hospital (US)
- Corresponding author
- Poole, Elizabeth M.
- Venue
- Cancer Epidemiology, Biomarkers & Prevention
- Published
- 2011-05-01
- Volume
- 20
- Issue
- 5
- Pages
- 934-938
- ISSN
- 1055-9965 (ISSN-L)
- 1538-7755
- PMC
- PMC3089706
- OpenAlex
- W2154152340
- Cited by
- 58
- References
- 26
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 3 · 2023: 2 · 2022: 3 · 2021: 2 · 2020: 5 · 2019: 3 · 2018: 7 · 2017: 3 · 2016: 3 · 2015: 6 · 2014: 4 · 2013: 8 · 2012: 5
- FWCI
- 7.41
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Cancer Epidemiology Biomarkers & Prevention (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (P01CA087969, R01CA050385, [P01 CA87969, T32CA009001)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Oncology › Cancer Risks and Factors
- Keywords
- rotating night shift work, ovarian cancer, occupational cancer risk, Nurses' Health Study, Nurses' Health Study II, melatonin, reproductive cancers
- MeSH terms
- Adult, Aged, Female, Follow-Up Studies, Humans, Middle Aged, Nurses, Ovarian Neoplasms, Prognosis, Prospective Studies, Risk Factors, Work Schedule Tolerance, Cohort Studies
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