The Effect of Exercise Training on Mediators of Inflammation in Breast Cancer Survivors: A Systematic Review with Meta-analysis
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Abstract
Several sources of evidence indicate that exercise during and after breast cancer could positively modulate the tumor microenvironment. This meta-analysis aimed to determine the effects of exercise training on mediators of inflammation in breast cancer survivors. We searched for randomized controlled trials published from January 1990 to March 2014. An inverse variance method of meta-analysis was performed using a random effects model in the presence of statistical heterogeneity. Eight high-quality trials (n = 478) were included. Exercise improved the serum concentrations of IL6 [weighted mean difference (WMD) = −0.55 pg/mL; 95% confidence interval (CI), −1.02 to −0.09], TNFα (WMD = −0.64 pg/mL; 95% CI, −1.21 to −0.06), IL8 (MD = −0.49 pg/mL; 95% CI, −0.89 to −0.09), and IL2 (WMD = 1.03 pg/mL; 95% CI, 0.40 to 1.67). No significant differences were found in the serum concentrations of C-reactive protein (WMD = −0.15; 95% CI, −0.56 to 0.25) or IL10 (WMD = 0.41; 95% CI, −0.18 to 1.02). Exercise training positively modulates chronic low-grade inflammation in women with breast cancer, which may impact upon carcinogenic mechanisms and the tumor microenvironment. These findings align with the other positive effects of exercise for breast cancer survivors, reinforcing the appropriateness of exercise prescription in this population. Cancer Epidemiol Biomarkers Prev; 25(7); 1009–17. ©2016 AACR.
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Low physical activity is directly related to increased anabolic resistance and levels of CRP and pro-inflammatory cytokines in healthy individuals, breast cancer survivors, and patients with type 2 diabetes.
“Low physical activity, therefore, has been found to be directly related to increased anabolic resistance96 and levels of CRP and pro-inflammatory cytokine levels in healthy individuals97, as well as in breast cancer survivors98 and patients with type 2 diabetes99.”
From Chronic inflammation in the etiology of disease across the life span (2019) · cites this paper as [98]
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References 54 · Cited by 169
Research works printed but not linked: 2
- Wolin KY, Schwartz AL, Matthews CE, Courneya KS, Schmitz KH. Imple- menting the exercise guidelines for cancer survivors. J Support Oncol 2012;10:171-7.
- Schubert C, Hong S, Natarajan L, Mills PJ, Dimsdale JE. The association between fatigue and inflammatory marker levels in cancer patients: a quantitative review. Brain Behav Immun 2007;21:413-27.
- Authors
- Meneses-Echávez, J. F., Correa-Bautista, J. E., González-Jiménez, E., Schmidt Río-Valle, J., Elkins, M. R., Lobelo, F., & Ramírez-Vélez, R.
- Affiliations
- 1Norwegian Knowledge Centre for the Health Services in the Norwegian Institute of Public Health, Oslo, Norway.
- 2Centro de Estudios en Medición de la Actividad Física (CEMA), Escuela de Medicina y Ciencias de la Salud, Universidad del Rosario, Bogotá, Colombia.
- 3Department of Nursing, University of Granada, Granada, Spain.
- The University of Sydney (AU)
- Emory University (US)
- Venue
- Cancer Epidemiology, Biomarkers & Prevention
- Published
- 2016-06-30
- Volume
- 25
- Issue
- 7
- Pages
- 1009-1017
- ISSN
- 1055-9965 (ISSN-L)
- 1538-7755
- OpenAlex
- W2338911840
- Cited by
- 169
- References
- 54
- Citations by year
- 2026: 10 · 2025: 15 · 2024: 25 · 2023: 20 · 2022: 14 · 2021: 32 · 2020: 15 · 2019: 13 · 2018: 9 · 2017: 15 · 2016: 1
- FWCI
- 1.27
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cancer Epidemiology Biomarkers & Prevention (publishedVersion)
- PubMed (publishedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Oncology › Cancer survivorship and care
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Health Sciences › Medicine › Oncology › Cancer Risks and Factors
- Keywords
- exercise training, breast cancer survivors, inflammation, tumor microenvironment, interleukin-6, TNF-α, interleukin-8, interleukin-2, C-reactive protein, IL-10, low-grade inflammation, exercise prescription
- MeSH terms
- Cancer Survivors, Breast Neoplasms, C-Reactive Protein, Enzyme-Linked Immunosorbent Assay, Exercise Therapy, Female, Humans, Middle Aged, Regression Analysis, Exercise, Interleukin-6, Randomized Controlled Trials as Topic, Interleukin-10, Inflammation Mediators, Physical Conditioning, Human
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