The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Hematogenous Metastasis in Gastric Cancer Requires Isolated Tumor Cells and Expression of Vascular Endothelial Growth Factor Receptor-1
Abstract
Purpose: Recent studies of cancer metastasis have focused on the role of premetastatic gene expression and circulating tumor cells. We did a blind prospective study in gastric cancer to assess the significance of isolated tumor cells (ITC) and to test the hypothesis that vascular endothelial growth factor receptor-1 (VEGFR-1) is expressed within the bone marrow at tumor-specific, premetastatic sites. Experimental Design: Both bone marrow and peripheral blood samples from 810 gastric cancer patients were collected at the Central Hospital, National Cancer Center (Tokyo, Japan). The samples were transferred to Kyushu University Hospital (Beppu, Japan) where they were analyzed by quantitative real-time reverse transcription-PCR for three epithelial cell markers, carcinoembryonic antigen, cytokeratin-19, and cytokeratin-7, as well as VEGFR-1. Results: ITCs were observed in peripheral blood and bone marrow even in early stages of gastric cancer. The frequency of ITC in bone marrow was significantly associated with the stage of disease by ANOVA (P < 0.01). Gastric cancer metastasized when ITCs were observed in the presence of VEGFR-1. In the 380 patients who were ITC negative and showed low VEGFR-1 expression, synchronous (at the time of surgery) and heterochronous (recurrent) metastases were not observed. Conclusions: ITCs circulate even in early stages of disease. Furthermore, elevated expression of VEGFR-1 facilitates the establishment of hematogenous metastases in gastric cancer. This study indicates that the simultaneous presence of ITC and VEGFR-1 expression at premetastatic sites is clinically significant for disease progression.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Previous literature has demonstrated that gastric tumors may recur a few years after resection even if a curative R0 according to postoperative pathological diagnosis 26, 27.”
From Prognostic significance of postoperative pneumonia after curative resection for patients with gastric cancer (2017) · cites this paper as [26]
Citations
Cites
VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche
Kaplan, R. N., Riba, R. D., Zacharoulis, S., Bramley, A. H., Vincent, L., Costa, C., MacDonald, D. D., Jin, D. K., Shido, K., Kerns, S. A., et al. (2005) · Nature · doi:10.1038/nature04186 · Cited by 3,288
A Perivascular Niche for Brain Tumor Stem Cells
Calabrese, C. R., Poppleton, H., Koçak, M., Hogg, T. L., Fuller, C. E., Hamner, J. B., Oh, E. Y., Gaber, M. W., Finklestein, D., Allen, M., et al. (2007) · Cancer Cell · doi:10.1016/j.ccr.2006.11.020 · Cited by 2,253
Japanese Classification of Gastric Carcinoma – 2nd English Edition –
Japanese Gastric Cancer Association (1998) · Gastric Cancer · doi:10.1007/pl00011681 · Cited by 2,182
Preparing the “Soil”: The Premetastatic Niche
Kaplan, R. N., Rafii, S., & Lyden, D. C. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-2407 · Cited by 681
Folkins, C., Man, S., Xu, P., Shaked, Y., Hicklin, D. J., & Kerbel, R. S. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-4238 · Cited by 383
Burchill, S. A., Bradbury, M., Pittman, K. B., Southgate, J., Smith, B., & Selby, P. J. (1995) · British Journal of Cancer · doi:10.1038/bjc.1995.56 · Cited by 326
Yamaguchi, K., Takagi, Y., Aoki, S., Futamura, M., & Saji, S. (2000) · Annals of Surgery · doi:10.1097/00000658-200007000-00009 · Cited by 322
Lecomte, T., Berger, A., Zinzindohoué, F., Micard, S., Landi, B., Blons, H., Beaune, P. H., Cugnenc, P., & Laurent‐Puig, P. (2002) · International Journal of Cancer · doi:10.1002/ijc.10526 · Cited by 291
Heiss, M. M., Allgayer, H., Gruetzner, K. U., Funke, I., Babic, R., Jauch, K., & Schildberg, F. W. (1995) · Nature Medicine · doi:10.1038/nm1095-1035 · Cited by 252
Prognostic significance of bone marrow micrometastases in patients with gastric cancer.
Jauch, K.-W., Heiss, M. M., Gruetzner, U., Funke, I., Pantel, K., Babic, R., Eissner, H. J., Riethmüeller, G., & Schildberg, F. W. (1996) · Journal of Clinical Oncology · doi:10.1200/jco.1996.14.6.1810 · Cited by 189
Flagged first, then by citations
Cited by
Sorted by citations
Circulating tumor cells (CTCs): Detection methods and their clinical relevance in breast cancer
Mostert, B., Sleijfer, S., Foekens, J. A., & Gratama, J. W. (2009) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2009.03.004 · Cited by 284
Ceci, C., Atzori, M. G., Lacal, P. M., & Graziani, G. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21041388 · Cited by 254
Prognostic Significance of Complications after Curative Surgery for Gastric Cancer
Kubota, T., Hiki, N., Sano, T., Nomura, S., Nunobe, S., Kumagai, K., Aikou, S., Watanabe, R., Kosuga, T., & Yamaguchi, T. (2013) · Annals of Surgical Oncology · doi:10.1245/s10434-013-3384-9 · Cited by 234
Circulating and disseminated tumor cells: harbingers or initiators of metastasis?
Dasgupta, A., Lim, A. R., & Ghajar, C. M. (2017) · Molecular Oncology · doi:10.1002/1878-0261.12022 · Cited by 225
Clinical and biological significance of circulating tumor cells in cancer
Masuda, T., Hayashi, N., Iguchi, T., Ito, S., Eguchi, H., & Mimori, K. (2016) · Molecular Oncology · doi:10.1016/j.molonc.2016.01.010 · Cited by 149
Self-citation
Metadata
- Authors
- Mimori, K., Fukagawa, T., Kosaka, Y., Kita, Y., Ishikawa, K., Etoh, T., Iinuma, H., Sasako, M., & Mori, M.
- Affiliations
- Medical Institute of Bioregulation, Kyushu University (JP)
- Teikyo University (JP)
- ORCID
- Venue
- Clinical Cancer Research
- Published
- 2008-05-01
- Volume
- 14
- Issue
- 9
- Pages
- 2609-2616
- ISSN
- 1078-0432 (ISSN-L)
- 1557-3265
- OpenAlex
- W2142670764
- Cited by
- 71
- References
- 32
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 2 · 2022: 2 · 2021: 3 · 2020: 1 · 2019: 1 · 2018: 2 · 2017: 7 · 2016: 4 · 2015: 8 · 2014: 5 · 2013: 6 · 2012: 7
- FWCI
- 3.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Cancer Research (publishedVersion)
- PubMed (publishedVersion)
- Institutional Repositories DataBase (IRDB) (submittedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Health Sciences › Medicine › Oncology › Gastric Cancer Management and Outcomes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Keywords
- gastric cancer, isolated tumor cells, VEGFR1, hematogenous metastasis, bone marrow, circulating tumor cells, carcinoembryonic antigen, cytokeratin 19, CK7, disease stage
- MeSH terms
- Adult, Aged, Aged, 80 and over, Bone Marrow, Carcinoembryonic Antigen, Female, Humans, Liver Neoplasms, Lung Neoplasms, Male, Middle Aged, Neoplastic Cells, Circulating, Neoplasm Metastasis, Prospective Studies, Stomach Neoplasms, Reverse Transcriptase Polymerase Chain Reaction, Vascular Endothelial Growth Factor Receptor-1, Keratin-19, Keratin-7
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
