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Loss of HER2 Amplification Following Trastuzumab-Based Neoadjuvant Systemic Therapy and Survival Outcomes
Open accessAbstract
PURPOSE: To evaluate HER2 status in residual tumor identified at the time of surgery in patients not achieving a pathologic complete response (pCR) and to determine the effect of alterations in HER2 status on recurrence-free survival (RFS). EXPERIMENTAL DESIGN: Clinicopathologic data for patients with HER2-overexpressing breast cancer receiving neoadjuvant therapy with a taxane, anthracycline, and concomitant trastuzumab between 2004 and 2007 were reviewed. Surgical specimens for patients achieving less than a pCR were assessed to determine if there was enough residual tissue to evaluate posttreatment HER2 status. RFS was determined using the Kaplan-Meier method and compared by the log-rank statistic. RESULTS: A pCR was achieved in 72 of the 142 (50.7%) patients. Residual tumor was sufficient to assess posttreatment HER2 status in 25 patients. Fluorescence in situ hybridization done on pretreatment specimens confirmed HER2 amplification before beginning therapy. Eight (32.0%) posttreatment tumors were found to be HER2-negative by fluorescence in situ hybridization. At a median follow-up of 37 months (range, 8-56 months), the RFS was significantly better for patients with tumors that retained HER2 amplification (87.5% versus 50%, P = 0.04). CONCLUSION: High pCR rates are achieved in patients with HER2-positive breast cancer treated with neoadjuvant trastuzumab in combination with anthracyclines and taxanes. One third of patients with significant residual disease loses HER2 amplification, and this change is associated with poor RFS. Residual tumor identified at the time of surgery should be reassessed for HER2 status, and novel adjuvant therapy strategies need to be studied in this population.
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“some patients with HER2+ tumors convert to HER2-negative following neoadjuvant trastuzumab and chemotherapy”
From ERBB Receptors: From Oncogene Discovery to Basic Science to Mechanism-Based Cancer Therapeutics (2014) · cites this paper as Mittendorf et al., 2009
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“these patients exhibit a shorter relapse-free survival compared to those with residual tumors that remain HER2 amplified (Hurley et al., 2006; Mittendorf et al., 2009).”
From ERBB Receptors: From Oncogene Discovery to Basic Science to Mechanism-Based Cancer Therapeutics (2014) · cites this paper as Mittendorf et al., 2009
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Cites
Slamon, D. J., Clark, G. M., Wong, S. G., Levin, W. J., Ullrich, A., & McGuire, W. L. (1987) · Science · doi:10.1126/science.3798106 · Cited by 11,760
Slamon, D. J., Leyland-Jones, B., Shak, S., Fuchs, H., Paton, V., Bajamonde, A., Fleming, T., Eiermann, W., Wolter, J., Pegram, M., et al. (2001) · New England Journal of Medicine · doi:10.1056/nejm200103153441101 · Cited by 11,500
Self-citationStudies of the HER-2/ neu Proto-Oncogene in Human Breast and Ovarian Cancer
Slamon, D. J., Godolphin, W. J., Jones, L. A., Holt, J. A., Wong, S., Keith, D. E., Levin, W. J., Stuart, S. G., Udove, J. A., Ullrich, A., et al. (1989) · Science · doi:10.1126/science.2470152 · Cited by 6,817
Trastuzumab plus Adjuvant Chemotherapy for Operable HER2-Positive Breast Cancer
Romond, E. H., Perez, E. A., Bryant, J., Suman, V. J., Geyer, C. E., Davidson, N. E., Tan-Chiu, E., Martino, S., Paik, S., Kaufman, P. A., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa052122 · Cited by 5,438
Trastuzumab after Adjuvant Chemotherapy in HER2-Positive Breast Cancer
Piccart-Gebhart, M. J., Procter, M., Leyland-Jones, B., Goldhirsch, A., Untch, M., Smith, I., Gianni, L., Baselga, J., Bell, R., Jackisch, C., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa052306 · Cited by 5,084
Self-citationWolff, A. C., Hammond, M. E., Schwartz, J. N., Hagerty, K. L., Allred, D. C., Côté, R. J., Dowsett, M., Fitzgibbons, P. L., Hanna, W. M., Langer, A. S., et al. (2006) · Journal of Clinical Oncology · doi:10.1200/jco.2006.09.2775 · Cited by 4,424
Cobleigh, M., Vogel, C. L., Tripathy, D., Robert, N. J., Scholl, S., Fehrenbacher, L., Wolter, J. M., Paton, V. E., Shak, S., Lieberman, G., et al. (1999) · Journal of Clinical Oncology · doi:10.1200/jco.1999.17.9.2639 · Cited by 2,767
Kuerer, H. M., Newman, L. A., Smith, T. L., Ames, F. C., Hunt, K. K., Dhingra, K., Theriault, R. L., Singh, G., Binkley, S. M., Sneige, N., et al. (1999) · Journal of Clinical Oncology · doi:10.1200/jco.1999.17.2.460 · Cited by 1,329
Self-citationLamon, D. E. J. S., Eyland, B. R. L., Hak, S. T. S., Uchs, H. A. F., Aton, V. I. P., Ajamonde, A. L. B., LeMing, T., Iermann, W. O. E., Olter, J. A. W., Egram, M. A. P., et al. (2009) · Cited by 1,199
Buzdar, A. U., Ibrahim, N. K., Francis, D., Booser, D. J., Thomas, E. S., Theriault, R. L., Pusztai, L., Green, M. C., Arun, B., Giordano, S. H., et al. (2005) · Journal of Clinical Oncology · doi:10.1200/jco.2005.07.032 · Cited by 1,174
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Items 101–200 of 331
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Kim, H. J., & Oh, S. C. (2018) · Journal of the Korean Gastric Cancer Association · doi:10.5230/jgc.2018.18.e3 · Cited by 45
Advances in Molecular and Clinical Subtyping of Breast Cancer and Their Implications for Therapy
Cadoo, K. A., Traina, T. A., & King, T. A. (2013) · Surgical Oncology Clinics of North America · doi:10.1016/j.soc.2013.06.006 · Cited by 43
He, X.-H., Zhu, W., Yuan, P., Jiang, S., Li, D., Zhang, H.-W., & Liu, M.-F. (2016) · Oncogene · doi:10.1038/onc.2016.132 · Cited by 43
Overcoming Treatment Resistance in HER2-Positive Breast Cancer
Puglisi, F., Minisini, A. M., Angelis, C. D., & Arpino, G. (2012) · Drugs · doi:10.2165/11634000-000000000-00000 · Cited by 41
G9a Promotes Breast Cancer Recurrence through Repression of a Pro-inflammatory Program
Mabe, N. W., Garcia, N. M. G., Wolery, S. E., Newcomb, R., Meingasner, R. C., Vilona, B. A., Lupo, R., Lin, C., Chi, J., & Alvarez, J. V. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108341 · Cited by 40
Discordance of HER2-Low between Primary Tumors and Matched Distant Metastases in Breast Cancer
Almstedt, K., Krauthauser, L., Kappenberg, F., Wagner, D., Heimes, A.-S., Battista, M. J., Anić, K., Krajnak, S., Lebrecht, A., Schwab, R. M., et al. (2023) · Cancers · doi:10.3390/cancers15051413 · Cited by 41
Loss of HER2 and disease prognosis after neoadjuvant treatment of HER2+ breast cancer.
Branco, F., Machado, D. H., Silva, F. F., André, S., Catarino, A., Madureira, R., Moreira-Pinto, J., Godinho, J. P. B., Simões, P., Brito, M., et al. (2019) · PubMed Central · Cited by 39
Gris‐Oliver, A., Palafox, M., Monserrat, L., Brasó‐Maristany, F., Òdena, A., Sánchez-Guixé, M., Ibrahim, Y. H., Villacampa, G. J., Grueso, J., Parés, M., et al. (2020) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-19-3324 · Cited by 39
Self-citationIntrinsic Resistance to Chemotherapy in Breast Cancer
Moulder, S. (2010) · Women s Health · doi:10.2217/whe.10.60 · Cited by 39
Tarantino, P., Ajari, O. W., Graham, N., Vincuilla, J., Parker, T., Hughes, M. E., Tayob, N., Garrido-Castro, A. C., Morganti, S., King, T. A., et al. (2024) · European Journal of Cancer · doi:10.1016/j.ejca.2024.113920 · Cited by 40
Self-citationLi, C., Fan, H., Xiang, Q., Xu, L., Zhang, Z., Liu, Q., Zhang, T., Ling, J., Zhou, Y. F., Zhao, X., et al. (2019) · Breast Cancer Research and Treatment · doi:10.1007/s10549-019-05421-7 · Cited by 38
Khasraw, M., Brogi, E., & Seidman, A. D. (2010) · Current Oncology Reports · doi:10.1007/s11912-010-0137-9 · Cited by 37
Neutralization of BCL-2/XL Enhances the Cytotoxicity of T-DM1 In Vivo
Zoeller, J. J., Vagodny, A., Taneja, K. L., Tan, B. Y., O’Brien, N. A., Slamon, D. J., Sampath, D., Leverson, J. D., Bronson, R. T., Dillon, D. A. R., et al. (2019) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-18-0743 · Cited by 37
Du, S., Luo, C., Yang, G., Gao, H., Wang, Y., Li, X., Zhao, H., Luo, Q., Ma, X., Shi, J., et al. (2020) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.0c00334 · Cited by 37
Prognostic implications of receptor discordance between primary and recurrent breast cancer
Matsumoto, A., Jinno, H., Murata, T., Seki, T., Takahashi, M., Hayashida, T., Kameyama, K., & Kitagawa, Y. (2014) · International Journal of Clinical Oncology · doi:10.1007/s10147-014-0759-2 · Cited by 37
Zhu, S., Lu, Y., Fei, X., Shen, K., & Chen, X. (2023) · British Journal of Cancer · doi:10.1038/s41416-023-02403-x · Cited by 35
Antibody-lectin chimeras for glyco-immune checkpoint blockade
Stark, J. C., Gray, M. A., Ibarlucea-Benitez, I., Lustig, M., Bond, A., Cho, B., Govil, I., Luu, T., Priestley, M. J., Veth, T. S., et al. (2025) · Nature Biotechnology · doi:10.1038/s41587-025-02884-6 · Cited by 41
Martín-Castillo, B., López‐Bonet, E., Cuyàs, E., Viñas, G., Pernas, S., Dorca, J., & Menéndez, J. A. (2015) · Oncotarget · doi:10.18632/oncotarget.6094 · Cited by 35
An anti-EGFR antibody-drug conjugate overcomes resistance to HER2-targeted drugs
Gandullo‐Sánchez, L., & Pandiella, A. (2022) · Cancer Letters · doi:10.1016/j.canlet.2022.216024 · Cited by 32
Fracol, M. E., Xu, S., Mick, R., Fitzpatrick, E., Nisenbaum, H. L., Roses, R. E., Fisher, C. S., Tchou, J. C., Fox, K. R., Zhang, P., et al. (2013) · Annals of Surgical Oncology · doi:10.1245/s10434-013-3119-y · Cited by 34
Companion Diagnostics in Oncology - Current Status and Future Aspects
Jørgensen, J. T. (2013) · Oncology · doi:10.1159/000353454 · Cited by 34
Gonzalez-Angulo, A. M., Liu, S., Chen, H., Chávez‐MacGregor, M., Şahin, A. A., Hortobágyi, G. N., Mills, G. B., Do, K.-A., & Meric‐Bernstam, F. (2012) · Annals of Oncology · doi:10.1093/annonc/mds530 · Cited by 34
Self-citationGoh, G., Schmid, R., Guiver, K., Arpornwirat, W., Chitapanarux, I., Ganju, V., Im, S., Kim, S., Dechaphunkul, A., Maneechavakajorn, J., et al. (2016) · PLoS Medicine · doi:10.1371/journal.pmed.1002136 · Cited by 34
Peng, J., Zhang, X., Song, J., Liang, R., Luo, R., Li, H., & Wang, Y. (2019) · Medicine · doi:10.1097/md.0000000000013554 · Cited by 34
Kijima, T., Arigami, T., Uenosono, Y., Hiraki, T., Yanagita, S., Matsushita, D., Okubo, K., Shimonosono, M., Ishigami, S., Maemura, K., et al. (2019) · Anticancer Research · doi:10.21873/anticanres.13927 · Cited by 34
Rosati, D., & Giordano, A. (2021) · Biochemical Pharmacology · doi:10.1016/j.bcp.2021.114811 · Cited by 36
Cross-Resistance Among Sequential Cancer Therapeutics: An Emerging Issue
Loria, R., Vici, P., Lisa, F. S. D., Soddu, S., Maugeri‐Saccà, M., & Bon, G. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.877380 · Cited by 34
Zhao, F., Miyashita, M., Hattori, M., Yoshimatsu, T. F., Howard, F. M., Kaneva, K., Jones, R., Bell, J. S. K., Fleming, G. F., Jaskowiak, N. T., et al. (2023) · JAMA Network Open · doi:10.1001/jamanetworkopen.2023.3329 · Cited by 33
Challenges and prospects in HER2-positive breast cancer-targeted therapy
Li, X., Zhang, X., Yin, S., & Nie, J. (2025) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2025.104624 · Cited by 39
Li, X., Wang, M., Wang, M., Yu, X., Guo, J., Sun, T., Yao, L., Zhang, Q., & Xu, Y. (2019) · Journal of Breast Cancer · doi:10.4048/jbc.2019.22.e49 · Cited by 31
Pathology after neoadjuvant treatment – How to assess residual disease
Viale, G., & Fusco, N. (2021) · The Breast · doi:10.1016/j.breast.2021.11.009 · Cited by 31
Hosking, M. P., Shirinbak, S., Omilusik, K., Chandra, S., Kaneko, M., Gentile, A., Yamamoto, S., Shrestha, B., Grant, J., Boyett, M., et al. (2025) · Cell Stem Cell · doi:10.1016/j.stem.2025.05.007 · Cited by 30
Signatures of Tumor–Immune Interactions as Biomarkers for Breast Cancer Prognosis
Manjili, M. H., Najarian, K., & Wang, X. (2012) · Future Oncology · doi:10.2217/fon.12.57 · Cited by 30
Tintelnot, J., Goekkurt, E., Binder, M., Thuss-Patience, P. C., Lorenzen, S., Knorrenschild, J. R., Kretzschmar, A., Ettrich, T. J., Lindig, U., Jacobasch, L., et al. (2020) · BMC Cancer · doi:10.1186/s12885-020-06958-3 · Cited by 30
Targeting HER2 heterogeneity in early-stage breast cancer
Pernas, S., & Tolaney, S. M. (2020) · Current Opinion in Oncology · doi:10.1097/cco.0000000000000685 · Cited by 31
Pinder, S. E., Rakha, E. A., Purdie, C. A., Bartlett, J. M. S., Francis, A., Stein, R. C., Thompson, A. M., & Shaaban, A. M. (2015) · Histopathology · doi:10.1111/his.12649 · Cited by 29
Current Approaches and Emerging Directions in HER2-resistant Breast Cancer
Brufsky, A. (2014) · Breast Cancer Basic and Clinical Research · doi:10.4137/bcbcr.s9453 · Cited by 29
Dong, Z., Huang, Z., Li, S., Wang, Y., Yao, Y., Yang, X., & Xu, X. (2022) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2022.09.021 · Cited by 30
Heitz, F., Barinoff, J., du Bois, O., Hils, R., Fisseler‐Eckhoff, A., Harter, P., Heitz, J., Willenbrock, K., Traut, A., & du Bois, A. (2013) · Oncology · doi:10.1159/000346184 · Cited by 29
Chong, Q.-Y., You, M., Pandey, V., Banerjee, A., Chen, Y., Poh, H.-M., Zhang, M., Ma, L., Zhu, T., Basappa, B., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.18431 · Cited by 28
Resistance to Neoadjuvant Treatment in Breast Cancer: Clinicopathological and Molecular Predictors
Chica-Parrado, M. D. R., Godoy-Ortíz, A., Jiménez, B., Ribelles, N., Barragán, I., & Alba, E. (2020) · Cancers · doi:10.3390/cancers12082012 · Cited by 29
Recent developments in peptide-based SPECT radiopharmaceuticals for breast tumor targeting
Ahmadpour, S., & Hosseinimehr, S. J. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.116870 · Cited by 28
Dowling, G. P., Keelan, S., Cosgrove, N. S., Daly, G. R., Giblin, K., Toomey, S., Hennessy, B. T., & Hill, A. D. K. (2024) · Breast Cancer Research and Treatment · doi:10.1007/s10549-024-07431-6 · Cited by 27
Latest biopsy approach for suspected metastases in patients with breast cancer
Niikura, N., Odisio, B. C., Tokuda, Y., Symmans, W. F., Hortobágyi, G. N., & Ueno, N. T. (2013) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2013.182 · Cited by 27
Influence of Neoadjuvant Chemotherapy on HER2/neu Status in Invasive Breast Cancer
Li, P., Liu, T., Wang, Y., Shao, S., Zhang, W., Lv, Y., Yi, J., & Wang, Z. (2012) · Clinical Breast Cancer · doi:10.1016/j.clbc.2012.09.011 · Cited by 27
Cockburn, A., Yan, J., Rahardja, D., Euhus, D., Peng, Y. S., Fang, Y. V., & Sarode, V. R. (2013) · Human Pathology · doi:10.1016/j.humpath.2013.09.002 · Cited by 27
Breast specimen handling and reporting in the post-neoadjuvant setting: challenges and advances
Mrkonjic, M., Berman, H. K., Done, S. J., Youngson, B. J., & Mulligan, A. M. (2019) · Journal of Clinical Pathology · doi:10.1136/jclinpath-2018-205598 · Cited by 26
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Torigoe, H., Shien, K., Takeda, T., Yoshioka, T., Namba, K., Sato, H., Suzawa, K., Yamamoto, H., Soh, J., Sakaguchi, M., et al. (2018) · Cancer Science · doi:10.1111/cas.13571 · Cited by 25
Gameiro, A., Nascimento, C., Correia, J., & Ferreira, F. (2021) · Cancers · doi:10.3390/cancers13092007 · Cited by 28
Ahn, S., Kim, H. J., Kim, M., Chung, Y. R., Kang, E., Kim, E., Kim, S. H., Kim, Y. J., Kim, J. H., Kim, I. A., et al. (2018) · Cancer Research and Treatment · doi:10.4143/crt.2017.552 · Cited by 25
Texture Analysis of Breast DCE-MRI Based on Intratumoral Subregions for Predicting HER2 2+ Status
Lu, H., & Yin, J. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.00543 · Cited by 24
Betts, A. M., Clark, T. H., Jasper, P., Tolsma, J., van der Graaf, P. H., Graziani, E. I., Rosfjord, E. C., Sung, M. S., Ma, D., & Barletta, F. (2020) · Journal of Pharmacokinetics and Pharmacodynamics · doi:10.1007/s10928-020-09702-3 · Cited by 24
Coiro, S., Gasparini, E., Falco, G., Santandrea, G., Foroni, M., Besutti, G., Iotti, V., Cicilia, R. D., Foroni, M., Mele, S., et al. (2021) · Diagnostics · doi:10.3390/diagnostics11122249 · Cited by 24
Ishimine, Y., Goto, A., Watanabe, Y., Yajima, H., Nakagaki, S., Yabana, T., Adachi, T., Kondo, Y., & Kasai, K. (2015) · Case Reports in Gastrointestinal Medicine · doi:10.1155/2015/132030 · Cited by 24
PI3K Pathway Mutations and PTEN Levels in Primary and Metastatic Breast Cancer
Miller, T., & Arteaga, C. (2011) · Breast Diseases A Year Book Quarterly · doi:10.1016/j.breastdis.2011.10.024 · Cited by 24
Adding Adjuvant Systemic Treatment after Neoadjuvant Therapy in Breast Cancer: Review of the Data
Patel, S. A., & DeMichele, A. M. (2017) · Current Oncology Reports · doi:10.1007/s11912-017-0613-6 · Cited by 22
Breast cancer, neoadjuvant chemotherapy and residual disease
Chávez‐MacGregor, M., & Gonzalez-Angulo, A. M. (2010) · Clinical & Translational Oncology · doi:10.1007/s12094-010-0538-0 · Cited by 22
Self-citationEscrivá-de-Romaní, S., & Saura, C. (2023) · Cancer Drug Resistance · doi:10.20517/cdr.2022.52 · Cited by 22
Metastases to and from the Breast
Bombonati, A., & Lerwill, M. F. (2012) · Surgical pathology clinics · doi:10.1016/j.path.2012.06.004 · Cited by 21
Rossi, L., Verrico, M., Tomao, F., Ricci, F., Fontana, A., Spinelli, G. P., Colonna, M., Vici, P., & Tomao, F. (2019) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-019-03981-5 · Cited by 21
Ghadban, T., Jessen, A., Reeh, M., Dibbern, J. L., Mahner, S., Müller, V., Wellner, U. F., Güngör, C., Izbicki, J. R., & Vashist, Y. K. (2016) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2016.2696 · Cited by 20
Asgari-Karchekani, S., Aryannejad, A., Mousavi, S. A., Shahsavarhaghighi, S., & Tavangar, S. M. (2022) · Medical Oncology · doi:10.1007/s12032-022-01817-6 · Cited by 23
Yang, L., Bhattacharya, A., Peterson, D. L., Li, Y., Liu, X., Marangoni, E., Robila, V., & Zhang, Y. (2024) · Drug Resistance Updates · doi:10.1016/j.drup.2024.101078 · Cited by 20
Resistance to Targeted Therapies in Breast Cancer
Braga, S. A. (2016) · Methods in molecular biology · doi:10.1007/978-1-4939-3347-1_8 · Cited by 21
Chen, Y., Liu, X., Yu, K., Sun, X., Xu, S., Qiu, P., Lv, Z., Zhang, X., Guo, A., & Xu, Y. (2022) · Annals of Translational Medicine · doi:10.21037/atm-21-6924 · Cited by 19
Chan, A., Morey, A. L., Brown, B., Hastrich, D. J., Willsher, P. C., & Ingram, D. (2012) · BMC Cancer · doi:10.1186/1471-2407-12-555 · Cited by 19
Yuan, J., Ding, N., & Xiao, Z. Q. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.537265 · Cited by 19
Allegretti, M., Fabi, A., Giordani, E., Ercolani, C., Romania, P., Nisticò, C., Gasparro, S., Barberi, V., Ciolina, M., Pescarmona, E. O., et al. (2021) · Molecular Cancer · doi:10.1186/s12943-021-01438-z · Cited by 19
Discordance of HER2 Expression and/or Amplification on Repeat Testing
DiPeri, T. P., Kong, K., Varadarajan, K., Karp, D. D., Ajani, J. A., Pant, S., Press, M. F., Piha-Paul, S. A., Dumbrava, E. E. I., & Meric‐Bernstam, F. (2023) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-22-0630 · Cited by 18
Self-citationFabi, A., Mottolese, M., & Segatto, O. (2014) · Journal of Molecular Medicine · doi:10.1007/s00109-014-1169-7 · Cited by 18
Krell, J., James, C. R., Shah, D., Gojiš, O., Lim, A. K. P., Riddle, P., Ahmad, R., Makris, A., Cowdray, A., Chow, A., et al. (2011) · Clinical Breast Cancer · doi:10.1016/j.clbc.2011.03.012 · Cited by 18
Esteva, F. J., Franco, S. X., Hagan, M. K., Brewster, A. M., Somer, R. A., Williams, W., Florance, A. M., Turner, S., Stein, S., & Perez, A. (2013) · The Oncologist · doi:10.1634/theoncologist.2012-0129 · Cited by 18
Self-citationMechanisms of resistance to trastuzumab in HER2-positive gastric cancer
Li, Z., Zhao, H., Hu, H., Shang, H.-L., Ren, Y., Qiu, W., Su, H., Lyu, H., & Chen, X. (2024) · Chinese Journal of Cancer Research · doi:10.21147/j.issn.1000-9604.2024.03.07 · Cited by 17
Gouda, M. A., Gonugunta, A. S., Dumbrava, E. E. I., Yap, T. A., Rodon, J. A., Piha-Paul, S. A., Pohlmann, P. R., Damodaran, S., Murthy, R. K., Valero, V., et al. (2025) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-24-3468 · Cited by 17
Self-citationZelnak, A. B., Nikolinakos, P. G., Srinivasiah, J., Jonas, W. S., Pippas, A. M., Liu, Y., Li, X., Torres, M. A., & O'Regan, R. M. (2014) · Clinical Breast Cancer · doi:10.1016/j.clbc.2014.06.004 · Cited by 17
Feng, Z., Wen, H., Ju, X., Bi, R., Chen, X., Yang, W., & Wu, X. (2017) · Oncotarget · doi:10.18632/oncotarget.15858 · Cited by 17
Ran, R., Zhao, S., Zhou, Y., Hang, X., Wang, H. Z., Fan, Y., Zhang, Y., Qiao, Y., Yang, J., & Dong, D. (2024) · BMC Cancer · doi:10.1186/s12885-024-12974-4 · Cited by 16
Tanaka, S., Luk, S. O., Kiyokawa, J., Onozato, M. L., Iafrate, A. J., Shah, K., Martuza, R. L., Rabkin, S. D., Batchelor, T. T., Cahill, D. P., et al. (2019) · Scientific Reports · doi:10.1038/s41598-018-37437-2 · Cited by 15
Lu, Y., Tong, Y., Chen, X., & Shen, K. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.638619 · Cited by 16
Bossuyt, V., Provenzano, E., Symmans, W. F., Webster, F., Allison, K. H., Dang, C. T., Gobbi, H., Kulka, J., Lakhani, S. R., Moriya, T., et al. (2024) · Histopathology · doi:10.1111/his.15165 · Cited by 16
Kleeberg, U. R., Fink, M. K., Tessen, H.-W., Nennecke, A., Hentschel, S., & Bartels, S. (2013) · Oncology Research and Treatment · doi:10.1159/000351253 · Cited by 16
New developments in the treatment of HER2-positive breast cancer
Nahta, R. (2012) · Breast Cancer Targets and Therapy · doi:10.2147/bctt.s24976 · Cited by 16
Laokulrath, N., Gudi, M. A., Salahuddin, S. A., Chong, A. P. Y., Ding, C. S. L., Iqbal, J., Leow, W. Q., Tan, B. Y., Tse, G. M.-K., Rakha, E. A., et al. (2024) · Histopathology · doi:10.1111/his.15213 · Cited by 15
Pathological complete response in younger and older breast cancer patients
Kołacińska, A., Chałubińska, J., Błasińska-Morawiec, M., Dowgier-Witczak, I., Fendler, W. M., Kordek, R., & Morawiec, Z. (2012) · Archives of Medical Science · doi:10.5114/aoms.2012.28559 · Cited by 15
Mayer, E. L., Gropper, A. B., Harris, L. N., Gold, J. M., Parker, L. M., Kuter, I., Come, S. E., Najita, J., Guo, H., Winer, E. P., et al. (2014) · Clinical Breast Cancer · doi:10.1016/j.clbc.2014.07.010 · Cited by 15
Ge, W., Yang, B., Wen-shu, Z., Zheng, G., Dai, Y., Han, C., Yang, L. H., & Zheng, M. (2014) · Thoracic Cancer · doi:10.1111/1759-7714.12133 · Cited by 14
NBRST Investigators Group, Beitsch, P. D., Whitworth, P. W., Baron, P. L., Pellicane, J. V., Treece, T., Yoder, E. B., & Gittleman, M. A. (2016) · Annals of Surgical Oncology · doi:10.1245/s10434-016-5329-6 · Cited by 14
Alterations in Breast Cancer Biomarkers Following Neoadjuvant Therapy
Mohan, S. C., Walcott‐Sapp, S., Lee, M. K., Srour, M. K., Kim, S., Amersi, F. F., Giuliano, A. E., & Chung, A. P. (2021) · Annals of Surgical Oncology · doi:10.1245/s10434-021-09814-1 · Cited by 14
Niu, J., Gelbspan, D., Weitz, D. J., Markman, M., & Quan, W. (2014) · PubMed Central · doi:10.3978/j.issn.2078-6891.2014.045 · Cited by 14
Pathology Considerations in Patients Treated with Neoadjuvant Chemotherapy
Sahoo, S., & Lester, S. C. (2012) · Surgical pathology clinics · doi:10.1016/j.path.2012.06.005 · Cited by 14
He, Y., Zhang, J., Chen, H., Zhou, Y., Hong, L., Ma, Y., Chen, N., Zhao, W., & Tong, Z. (2023) · Frontiers in Surgery · doi:10.3389/fsurg.2022.1037215 · Cited by 13
Self-citationModern therapies and iatrogenic changes in breast pathology
Provenzano, E., & Pinder, S. E. (2016) · Histopathology · doi:10.1111/his.13098 · Cited by 13
Xu, L., Duan, X., Zhou, B., Liu, Y., Ye, J., Liu, Z., Ma, C., Zhang, H., Zhang, S., Zhang, L., et al. (2018) · The Breast · doi:10.1016/j.breast.2018.03.010 · Cited by 13
The neoadjuvant approach in breast cancer treatment: it is not just about chemotherapy anymore
Caudle, A. S., & Hunt, K. K. (2010) · Current Opinion in Obstetrics & Gynecology · doi:10.1097/gco.0b013e3283416477 · Cited by 13
Self-citationShu, S., Iimori, M., Nakanishi, R., Jogo, T., Saeki, H., Oki, E., & Maehara, Y. (2018) · In Vivo · doi:10.21873/invivo.11405 · Cited by 13
(2010) · Current Opinion in Obstetrics & Gynecology · doi:10.1097/gco.0b013e3283432017 · Cited by 13
Gao, Y., Shelling, A. N., Nolan, E., Porter, D. J. T., Leung, E. Y., & Wu, Z. (2024) · Journal of Liposome Research · doi:10.1080/08982104.2024.2305866 · Cited by 12
Development of Cell Technologies Based on Dendritic Cells for Immunotherapy of Oncological Diseases
Васильевич, К. В., Alshevskaya, A., & Sennikov, S. V. (2024) · Biomedicines · doi:10.3390/biomedicines12030699 · Cited by 13
Monitoring changing patterns in HER2 addiction by liquid biopsy in advanced breast cancer patients
Giordani, E., Allegretti, M., Sinibaldi, A., Michelotti, F., Ferretti, G., Ricciardi, E., Ziccheddu, G., Valenti, F., Martino, S. D., Ercolani, C., et al. (2024) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-024-03105-9 · Cited by 12
Mellouli, M., Graja, S., Kridis, W. B., Ayed, H. B., Makni, S., Triki, M., Charfi, S., Khanfir, A., Boudawara, T. S., & Kallel, R. (2022) · Annals of Diagnostic Pathology · doi:10.1016/j.anndiagpath.2022.152044 · Cited by 12
Metadata
- Authors
- Mittendorf, E. A., Wu, Y., Scaltriti, M., Meric-Bernstam, F., Hunt, K. K., Dawood, S., Esteva, F. J., Buzdar, A. U., Chen, H., Eksambi, S., Hortobagyi, G. N., Baselga, J., & Gonzalez-Angulo, A. M.
- Affiliations
- The University of Texas MD Anderson Cancer Center (US)
- Authors' Affiliations: Departments of 1Surgical Oncology, 2Pathology, 3Breast Medical Oncology, and 4Systems Biology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas; and 5Department of Medical Oncology, Vall d'Hebron Institute of Oncology, Vall d'Hebron University Hospital, Barcelona, Spain
- Corresponding author
- Gonzalez-Angulo, Ana M.
- ORCID
- Venue
- Clinical Cancer Research
- Published
- 2009-11-30
- Volume
- 15
- Issue
- 23
- Pages
- 7381-7388
- ISSN
- 1078-0432 (ISSN-L)
- 1557-3265
- PMC
- PMC2788123
- OpenAlex
- W2140927379
- Cited by
- 330
- References
- 31
- Citations by year
- 2026: 8 · 2025: 19 · 2024: 20 · 2023: 27 · 2022: 24 · 2021: 29 · 2020: 20 · 2019: 20 · 2018: 12 · 2017: 10 · 2016: 17 · 2015: 23 · 2014: 18 · 2013: 25 · 2012: 23
- FWCI
- 9.50
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Clinical Cancer Research (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (5k23ca121994-03, 1k99ca133244-01)
- National Cancer Institute (1K23CA121994-01), 1K99CA133244-01, K99 CA133244, K23-CA121994, 1K23CA121994)
- Topics
- Health Sciences › Medicine › Oncology › HER2/EGFR in Cancer Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Breast Cancer Treatment Studies
- Health Sciences › Medicine › Oncology › Gastric Cancer Management and Outcomes
- Keywords
- HER2 amplification, trastuzumab, neoadjuvant therapy, HER2-positive breast cancer, pathological complete response, residual tumor, recurrence-free survival, anthracyclines, taxanes, fluorescence in situ hybridization
- MeSH terms
- Trastuzumab, Adult, Aged, Aged, 80 and over, Antibodies, Monoclonal, Antineoplastic Agents, Breast Neoplasms, Female, Humans, Middle Aged, Recurrence, Treatment Outcome, Disease-Free Survival, Receptor, ErbB-2, Erb-b2 Receptor Tyrosine Kinases, Anthracyclines, Neoadjuvant Therapy, Taxoids, Cell Line, Tumor, Antibodies, Monoclonal, Humanized
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