The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
p27: A Barometer of Signaling Deregulation and Potential Predictor of Response to Targeted Therapies
Open accessAbstract
Phosphorylation of the cyclin-dependent kinase inhibitor p27 by upstream mitogenic signaling pathways regulates its stability, localization, and biological function. In human cancers, loss of the antiproliferative action of p27 can arise through reduced protein levels and/or cytoplasmic mislocalization, leading to increased cell proliferation and/or cell migration, respectively. Reduced p27 expression levels and p27 mislocalization have potential prognostic and therapeutic implications in various types of human cancers. This review highlights mechanisms of functional deregulation of p27 by oncogenic signaling that provide an important molecular rationale for pathway targeting in cancer treatment. Clin Cancer Res; 17(1); 12–8. ©2010 AACR.
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Cites
New functional activities for the p21 family of CDK inhibitors.
LaBaer, J., Garrett, M. D., Stevenson, L. F., Slingerland, J. M., Sandhu, C., Chou, H. S., Fattaey, A., & Harlow, E. (1997) · Genes & Development · doi:10.1101/gad.11.7.847 · Cited by 1,402
Self-citationmTOR and cancer: insights into a complex relationship
Sabatini, D. M. (2006) · Nature Reviews Cancer · doi:10.1038/nrc1974 · Cited by 1,322
García-Martínez, J. M., & Alessi, D. R. (2008) · Biochemical Journal · doi:10.1042/bj20081668 · Cited by 907
Diehl, J. A., Zindy, F., & Sherr, C. J. (1997) · Genes & Development · doi:10.1101/gad.11.8.957 · Cited by 746
Cheng, M., Sexl, V., Sherr, C. J., & Roussel, M. F. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.3.1091 · Cited by 496
Cited by
Amyloid-β precursor protein promotes cell proliferation and motility of advanced breast cancer
Lim, S., Yoo, B. K., Kim, H.-S., Gilmore, H. L., Lee, Y., Lee, H.-P., Kim, S.-J., Letterio, J., & Lee, H.-G. (2014) · BMC Cancer · doi:10.1186/1471-2407-14-928 · Cited by 100
Dulic, V. (2013) · Methods in Molecular Biology · doi:10.1007/978-1-62703-239-1_2 · Cited by 42
Metadata
- Authors
- Wander, S. A., Zhao, D., & Slingerland, J. M.
- Venue
- Clinical Cancer Research
- Published
- 2011-01-01
- Volume
- 17
- Issue
- 1
- Pages
- 12-18
- ISSN
- 1078-0432 (ISSN-L)
- 1557-3265
- OpenAlex
- W2103732635
- Cited by
- 178
- References
- 5
- FWCI
- 7.12
- Type
- journal article
- Language
- en
- Open access
- green
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- Wander, S. A., Zhao, D., & Slingerland, J. M. (2011). p27: A Barometer of Signaling Deregulation and Potential Predictor of Response to Targeted Therapies. Clinical Cancer Research. https://doi.org/10.1158/1078-0432.ccr-10-0752
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