Antitumor activity and pharmacodynamic properties of PX-478, an inhibitor of hypoxia-inducible factor-1α

Welsh, Sarah; Williams, Ryan; Kirkpatrick, Lynn; Paine-Murrieta, Gillian; Powis, Garth

doi:10.1158/1535-7163.233.3.3

Antitumor activity and pharmacodynamic properties of PX-478, an inhibitor of hypoxia-inducible factor-1α

The hypoxia-inducible factor-1 (HIF-1) transcription factor is an important regulator of tumor response to hypoxia that include increased angiogenesis, glycolytic metabolism, and resistance to apoptosis. HIF-1 activity is regulated by the availability of the HIF-1α subunit, the levels of which in…