Cited by 231Cell death mechanisms and regulationAutophagy in Disease and TherapyCellular transport and secretion

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Active Ras Triggers Death in Glioblastoma Cells through Hyperstimulation of Macropinocytosis

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Overmeyer, Jean H., Kaul, Aparna, Johnson, Erin E., Maltese, William A.·2008·Molecular Cancer Research

DOI 10.1158/1541-7786.mcr-07-2036PMC PMC2994605

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Abstract

Expression of activated Ras in glioblastoma cells induces accumulation of large phase-lucent cytoplasmic vacuoles, followed by cell death. This was previously described as autophagic cell death. However, unlike autophagosomes, the Ras-induced vacuoles are not bounded by a double membrane and do not sequester organelles or cytoplasm. Moreover, they are not acidic and do not contain the autophagosomal membrane protein LC3-II. Here we show that the vacuoles are enlarged macropinosomes. They rapidly incorporate extracellular fluid-phase tracers but do not sequester transferrin or the endosomal protein EEA1. Ultimately, the cells expressing activated Ras detach from the substratum and rupture, coincident with the displacement of cytoplasm with huge macropinosome-derived vacuoles. These changes are accompanied by caspase activation, but the broad-spectrum caspase inhibitor carbobenzoxy-Val-Ala-Asp-fluoromethylketone does not prevent cell death. Moreover, the majority of degenerating cells do not exhibit chromatin condensation typical of apoptosis. These observations provide evidence for a necrosis-like form of cell death initiated by dysregulation of macropinocytosis, which we have dubbed “methuosis.” An activated form of the Rac1 GTPase induces a similar form of cell death, suggesting that Ras acts through Rac-dependent signaling pathways to hyperstimulate macropinocytosis in glioblastoma. Further study of these signaling pathways may lead to the identification of other chemical and physiologic triggers for this unusual form of cell death. (Mol Cancer Res 2008;6(6):965–77)

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LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing.
Kabeya, Y., Mizushima, N., Ueno, T., Yamamoto, A., Kirisako, T., Noda, T., Kominami, E., Ohsumi, Y., & Yoshimori, T. (2000) · The EMBO Journal · doi:10.1093/emboj/19.21.5720 · Cited by 6,605
The small GTP-binding protein rac regulates growth factor-induced membrane ruffling
Ridley, A. J., Paterson, H. F., Johnston, C. L., Diekmann, D., & Hall, A. (1992) · Cell · doi:10.1016/0092-8674(92)90164-8 · Cited by 3,616
Apoptosis, oncosis, and necrosis. An overview of cell death.
Majno, G., & Joris, I. (1995) · PubMed · Cited by 3,328
Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury
Degterev, A., Huang, Z., Boyce, M., Li, Y., Jagtap, P., Mizushima, N., Cuny, G. D., Mitchison, T. J., Moskowitz, M. A., & Yuan, J. (2005) · Nature Chemical Biology · doi:10.1038/nchembio711 · Cited by 3,068
Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease
Ravikumar, B., Vacher, C., Berger, Z., Davies, J. E., Luo, S., Oroz, L. G., Scaravilli, F., Easton, D. F., Duden, R., O'Kane, C. J., et al. (2004) · Nature Genetics · doi:10.1038/ng1362 · Cited by 2,347
Role of autophagy in cancer
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Levine, B. (2005) · Journal of Clinical Investigation · doi:10.1172/jci26390 · Cited by 1,694
A Detergent‐trypsin method for the preparation of nuclei for flow cytometric DNA analysis
Vindeløv, L. L., Christensen, I. J., & Nissen, N. I. (1983) · Cytometry · doi:10.1002/cyto.990030503 · Cited by 1,633
Autophagy as a cell death and tumor suppressor mechanism
Gözüaçık, D., & Kimchi, A. (2004) · Oncogene · doi:10.1038/sj.onc.1207521 · Cited by 1,396
Death by design: apoptosis, necrosis and autophagy
Edinger, A. L., & Thompson, C. B. (2004) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2004.09.011 · Cited by 1,362

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Formation of a giant unilocular vacuole via macropinocytosis-like process confers anoikis resistancePreprint
Kim, J., Kim, D., Kim, D., Lee, S., Jang, W., & Lim, D. (2024) · eLife · doi:10.7554/elife.96178.3 · Cited by 4
PI3K/mTOR Inhibitor Induces Context-Dependent Apoptosis and Methuosis in Cancer Cells
Hua, X., Chen, P., Zeng, W., Han, Y., Guo, Y., Chen, Y., Li, C., Du, Y., Ma, M., & Dong, S. (2025) · Pharmaceuticals · doi:10.3390/ph18121849 · Cited by 3
Of Barriers and Loops—How Evolution Limits Most Cancer Risks to Older Ages
Dominici, M. D., & DeGregori, J. V. (2026) · Cancer Discovery · doi:10.1158/2159-8290.cd-25-0779 · Cited by 3
Cell-Specific Vulnerability of Human Glioblastoma and Astrocytoma Cells to Mephedrone—An In Vitro Study
Marszałek‐Grabska, M., Lemieszek, M. K., Chojnacki, M., Winiarczyk, S., Jakubowicz-Gil, J., Zarzyka, B., Pawelec, J., Kotlinska, J. H., Rzeski, W., & Turski, W. A. (2025) · Molecules · doi:10.3390/molecules30112277 · Cited by 3
Cell Injury and Necrosis
d’Avila, J. C., Levin, S., & Radi, Z. A. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.64220-4 · Cited by 3
Oral delivery of MOMIPP lipid nanoparticles for methuosis-induced cancer chemotherapy
Mao, Z., & Chai, G. (2025) · Nanoscale · doi:10.1039/d4nr04044a · Cited by 4
Self-Assembling Imidazolium Nanoaggregates Trigger a Unique Dynamin-Dependent Cell Death via Cytoplasmic Vacuolization and Mitochondrial Dysfunction in Human Lung Adenocarcinoma
Dewan, S., Sonker, H., Chaudhary, K., Agrawal, S., Chaudhary, A., Kumar, A., Agrahari, B., & Singh, R. G. (2025) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5c00651 · Cited by 3
[Mechanism of Platycarya strobilacea Sieb. et Zucc extract-induced methuosis in human nasopharyngeal carcinoma CNE1 and CNE2 cells].
Zhu, J., Tu, W., Zeng, C., Mao, H., Du, Q., & Cai, H. (2017) · Europe PMC (PubMed Central) · doi:10.3969/j.issn.1673-4254.2017.06.20 · Cited by 3
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Witt, D. (2013) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-4294 · Cited by 3
Milk makes lysosomes lethal
Krishna, S., & Overholtzer, M. (2014) · Nature Cell Biology · doi:10.1038/ncb3059 · Cited by 2
Metabolic cell death in cancer: mechanisms and therapeutic potential
Hao, Y., Shao, J., Lian, N., & Bian, M. (2025) · APOPTOSIS · doi:10.1007/s10495-025-02176-z · Cited by 2
Activation of virus uptake through induction of macropinocytosis with a novel polymerizing peptide
Daniels, S. I., Soule, E. E., Davidoff, K. S., Bernbaum, J. G., Hu, D., Maeda, K., Stahl, S. J., Naiman, N. E., Waheed, A. A., Freed, E. O., et al. (2013) · The FASEB Journal · doi:10.1096/fj.13-238113 · Cited by 2
Pattern of Histopathological Alterations in N-methyl-N-Nitrosourea (MNU) Induced Breast Cancer in Female Sprague Dawley (SD) Rats Treated with Crude Honey
Banik, U., Ahamed, S., Latt, S. S., Jalil, N. A. C., Rahman, W. F. W. A., & Othman, N. H. (2020) · Pertanika journal of science & technology · doi:10.47836/pjst.28.4.22 · Cited by 2
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Aki, T., Unuma, K., Funakoshi, T., & Uemura, K. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-95488-4.00013-9 · Cited by 1
Vacuolization as a Novel Approach to Cancer Therapy
Pasternak, M. A., Hussein, N. A., Piedra, V., Malla, S., Karthikeyan, C., Amawi, H. A., Rajak, H., Ashby, C. R., Babu, R. J., & Tiwari, A. K. (2026) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.70912 · Cited by 1
Matrine induces V-ATPase-dependent cytoplasmic vacuolation and inhibits the function of the lysosome in leukemia cells
Yang, F., Zhong, W., Cao, J., Tan, J., Li, B., & Ma, L. (2023) · Pharmaceutical Science Advances · doi:10.1016/j.pscia.2023.100013 · Cited by 1
Programmed cell death in human respiratory syncytial virus infection
Yao, P., Ma, C., & Liu, C. (2025) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2025.1719352 · Cited by 1
The Significance of the Feedback Loops between Kras and Ink4a in Pancreatic Cancer
Aguda, B. D. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-408103-1.00012-1 · Cited by 1
Modes of Chemically Induced Cell Death
Aki, T., Noritake, K., Funakoshi, T., & Uemura, K. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.01893-6 · Cited by 1
Studies on Autophagy and Apoptosis of Fibrosarcoma HT-1080 Cells Mediated by Chalcone with Indole Moiety
Honkisz-Orzechowska, E., Woźnicka, O., Kaleta, M., Handzlik, J., & Kieć‐Kononowicz, K. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25116100 · Cited by 1
The IL-1 family in relation to psoriasis
Doble, R. (2014) · White Rose eTheses Online (University of Leeds, The University of Sheffield, University of York)
Regulation of Fluid-phase Uptake in Podocytes by Albumin-associated Lipids
Chung, J.-J. (2014) · Open Scholarship Institutional Repository (Washington University in St. Louis) · doi:10.7936/k7862dfb
Using RNA aptamers to manipulate the functions of Human papillomaviruses (HPV)
Cesur, Ö. (2015) · White Rose eTheses Online (University of Leeds, The University of Sheffield, University of York)
Identification of compounds that target glioma initiating cells
Wee, S. (2015) · Figshare
Validated Cell Lines and References for NucView™ 488 Caspase-3 Substrate Scroll down for full references with links to journals Immortalized cell lines used with NucView™488 Caspase-3 Substrate
Epithelial, M. (2015)
Current state of the evolving MMMN cancer progression models of cancer
Thiagalingam, S. (2015) · Cambridge University Press eBooks · doi:10.1017/cbo9780511979811.022

Authors: Overmeyer, J. H., Kaul, A., Johnson, E. E., & Maltese, W. A.
Affiliations: University of Toledo (US)
ORCID: Johnson, Erin E.
Maltese, William A.
Venue: Molecular Cancer Research
Publisher: American Association for Cancer Research (AACR)
Published: 2008-06-01
Volume: 6
Issue: 6
Pages: 965-977
ISSN: 1541-7786 (ISSN-L)
1557-3125
DOI: 10.1158/1541-7786.mcr-07-2036
PMC: PMC2994605
OpenAlex: W2018951108
Cited by: 229
References: 56
Citations by year: 2026: 10 · 2025: 30 · 2024: 22 · 2023: 15 · 2022: 14 · 2021: 16 · 2020: 12 · 2019: 9 · 2018: 14 · 2017: 12 · 2016: 16 · 2015: 12 · 2014: 14 · 2013: 10 · 2012: 7
FWCI: 2.06
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Molecular Cancer Research (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Cancer Institute (R01 CA 34569, R01CA034569, R01CA115495)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
Keywords: activated Ras, glioblastoma, macropinocytosis, methuosis, necrosis-like cell death, macropinosomes, Rac1 GTPase, caspase activation, cytoplasmic vacuoles, cell detachment
MeSH terms: Brain Neoplasms, Glioblastoma, Humans, Necrosis, Pinocytosis, Vacuoles, Proto-Oncogene Proteins p21(ras), rac1 GTP-Binding Protein, Cell Line, Tumor

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Active Ras Triggers Death in Glioblastoma Cells through Hyperstimulation of Macropinocytosis

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