The DOI matches its Crossref record; 65 of the 65 references it cites were found in a registry or an index.
Comprehensive Transcriptome and Mutational Profiling of Endemic Burkitt Lymphoma Reveals EBV Type–Specific Differences
Open accessPublished version of a preprint
Abstract
Endemic Burkitt lymphoma (eBL) is the most common pediatric cancer in malaria-endemic equatorial Africa and nearly always contains Epstein–Barr virus (EBV), unlike sporadic Burkitt lymphoma (sBL) that occurs with a lower incidence in developed countries. Given these differences and the variable clinical presentation and outcomes, we sought to further understand pathogenesis by investigating transcriptomes using RNA sequencing (RNAseq) from multiple primary eBL tumors compared with sBL tumors. Within eBL tumors, minimal expression differences were found based on: anatomical presentation site, in-hospital survival rates, and EBV genome type, suggesting that eBL tumors are homogeneous without marked subtypes. The outstanding difference detected using surrogate variable analysis was the significantly decreased expression of key genes in the immunoproteasome complex (PSMB9/β1i, PSMB10/β2i, PSMB8/β5i, and PSME2/PA28β) in eBL tumors carrying type 2 EBV compared with type 1 EBV. Second, in comparison with previously published pediatric sBL specimens, the majority of the expression and pathway differences was related to the PTEN/PI3K/mTOR signaling pathway and was correlated most strongly with EBV status rather than geographic designation. Third, common mutations were observed significantly less frequently in eBL tumors harboring EBV type 1, with mutation frequencies similar between tumors with EBV type 2 and without EBV. In addition to the previously reported genes, a set of new genes mutated in BL, including TFAP4, MSH6, PRRC2C, BCL7A, FOXO1, PLCG2, PRKDC, RAD50, and RPRD2, were identified. Overall, these data establish that EBV, particularly EBV type 1, supports BL oncogenesis, alleviating the need for certain driver mutations in the human genome. Implications: Genomic and mutational analyses of Burkitt lymphoma tumors identify key differences based on viral content and clinical outcomes suggesting new avenues for the development of prognostic molecular biomarkers and therapeutic interventions. Mol Cancer Res; 15(5); 563–76. ©2017 AACR.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source doesn’t support the claim as written.
In the citing paper
“In addition, an RNA-seq study of patient tumors of EBL, a common childhood cancer from equatorial Africa where malaria is endemic, showed that the vast majority of cases which harbor EBV contain PLCγ2 mutations, along with mutations in other genes including MYC (142).”
From The role of PLCγ2 in immunological disorders, cancer, and neurodegeneration (2021) · cites this paper as [142]
Checked by a reasoning model — may be wrong.
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Interestingly, while MYC translocation and hyperexpression is a hallmark of EBL, it in itself is not sufficient to induce lymphogenesis (143), which may at least in part explain why mutations in PLCγ2 are relevant to the disease initiation (142).”
From The role of PLCγ2 in immunological disorders, cancer, and neurodegeneration (2021) · cites this paper as [142]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
Love, M. I., Huber, W., & Anders, S. (2014) · Genome Biology · doi:10.1186/s13059-014-0550-8 · Cited by 95,106
Subramanian, A., Tamayo, P., Mootha, V. K., Mukherjee, S., Ebert, B. L., Gillette, M. A., Paulovich, A., Pomeroy, S. L., Golub, T. R., Lander, E. S., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506580102 · Cited by 53,625
STAR: ultrafast universal RNA-seq aligner
Dobin, A., Davis, C. A., Schlesinger, F., Drenkow, J., Zaleski, C., Jha, S., Batut, P., Chaisson, M., & Gingeras, T. R. (2013) · Bioinformatics · doi:10.1093/bioinformatics/bts635 · Cited by 51,709
The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data
McKenna, A., Hanna, M., Banks, E., Sivachenko, A., Cibulskis, K., Kernytsky, A., Garimella, K., Altshuler, D., Gabriel, S., Daly, M., et al. (2010) · Genome Research · doi:10.1101/gr.107524.110 · Cited by 27,895
RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome
Li, B., & Dewey, C. N. (2011) · BMC Bioinformatics · doi:10.1186/1471-2105-12-323 · Cited by 22,179
Molecular signatures database (MSigDB) 3.0
Liberzon, A., Subramanian, A., Pinchback, R., Thorvaldsdóttir, H., Tamayo, P., & Mesirov, J. P. (2011) · Bioinformatics · doi:10.1093/bioinformatics/btr260 · Cited by 7,111
Kadoch, C., Hargreaves, D. C., Hodges, H. C., Elias, L., Ho, L., Ranish, J. A., & Crabtree, G. R. (2013) · Nature Genetics · doi:10.1038/ng.2628 · Cited by 1,493
Burkitt lymphoma pathogenesis and therapeutic targets from structural and functional genomics
Schmitz, R., Young, R. M., Ceribelli, M., Jhavar, S. G., Xiao, W., Zhang, M., Wright, G. W., Shaffer, A. L., Hodson, D. J., Buras, E. D., et al. (2012) · Nature · doi:10.1038/nature11378 · Cited by 935
Landscape of genomic alterations in cervical carcinomas
Ojesina, A. I., Lichtenstein, L., Freeman, S. S., Pedamallu, C. S., Imaz-Rosshandler, I., Pugh, T. J., Cherniack, A. D., Ambrogio, L., Cibulskis, K., Bertelsen, B. I., et al. (2013) · Nature · doi:10.1038/nature12881 · Cited by 874
Rowe, M., Rowe, D., Gregory, C. D., Young, L. S., Farrell, P. J., Rupani, H., & Rickinson, A. B. (1987) · The EMBO Journal · doi:10.1002/j.1460-2075.1987.tb02568.x · Cited by 711
Cited by
Sorted by citations
Alaggio, R., Amador, C., Anagnostopoulos, I., Attygalle, A. D., Araújo, I., Berti, E., Bhagat, G., Borges, A. M., Boyer, D. F., Calaminici, M., et al. (2022) · Leukemia · doi:10.1038/s41375-022-01620-2 · Cited by 4,059
Epstein–Barr virus-associated lymphomas
Shannon-Lowe, C. D., Rickinson, A. B., & Bell, A. I. (2017) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2016.0271 · Cited by 427
Grande, B. M., Gerhard, D. S., Jiang, A., Griner, N. B., Abramson, J. S., Alexander, T., Allen, H., Ayers, L. W., Bethony, J., Bhatia, K. G., et al. (2019) · Blood · doi:10.1182/blood-2018-09-871418 · Cited by 281
MRE11-RAD50-NBS1 complex alterations and DNA damage response: implications for cancer treatment
Bian, L., Meng, Y., Zhang, M., & Li, D. (2019) · Molecular Cancer · doi:10.1186/s12943-019-1100-5 · Cited by 267
The whole-genome landscape of Burkitt lymphoma subtypes
Panea, R., Love, C., Shingleton, J. R., Reddy, A., Bailey, J. A., Moormann, A. M., Otieno, J. A., Ong’echa, J. M., Oduor, C. I., Schroeder, K., et al. (2019) · Blood · doi:10.1182/blood.2019001880 · Cited by 194
Self-citationLópez, C., Kleinheinz, K., Aukema, S., Rohde, M., Bernhart, S. H., Hübschmann, D., Wagener, R., Toprak, U. H., Raimondi, F., Kreuz, M., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-08578-3 · Cited by 151
López, C., Burkhardt, B., Chan, J. K. C., Leoncini, L., Mbulaiteye, S. M., Ogwang, M. D., Orem, J., Rochford, R. A., Roschewski, M. J., & Siebert, R. (2022) · Nature Reviews Disease Primers · doi:10.1038/s41572-022-00404-3 · Cited by 154
The role of PLCγ2 in immunological disorders, cancer, and neurodegeneration
Jackson, J. T., Mulazzani, E., Nutt, S. L., & Masters, S. L. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.100905 · Cited by 113
“In addition, an RNA-seq study of patient tumors of EBL, a common childhood cancer from equatorial Africa where malaria is endemic, showed that the vast majority of cases which harbor EBV contain PLCγ2 mutations, along with mutations in other genes including MYC (142).”
Roschewski, M. J., Staudt, L. M., & Wilson, W. H. (2022) · New England Journal of Medicine · doi:10.1056/nejmra2025746 · Cited by 108
Understanding human health through metatranscriptomics
Ojala, T., Kankuri, E. M., & Kankainen, M. (2023) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2023.02.002 · Cited by 113
EBV-associated diseases: Current therapeutics and emerging technologies
Chakravorty, S., Afzali, B., & Kazemian, M. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1059133 · Cited by 114
Genetic subgroups inform on pathobiology in adult and pediatric Burkitt lymphoma
Thomas, N., Dreval, K., Gerhard, D. S., Hilton, L. K., Abramson, J. S., Ambinder, R. F., Barta, S. K., Bartlett, N. L., Bethony, J. M., Bhatia, K. G., et al. (2022) · Blood · doi:10.1182/blood.2022016534 · Cited by 91
EBV and Apoptosis: The Viral Master Regulator of Cell Fate?
Fitzsimmons, L., & Kelly, G. L. (2017) · Viruses · doi:10.3390/v9110339 · Cited by 79
Falini, B., Martino, G., & Lazzi, S. (2022) · Leukemia · doi:10.1038/s41375-022-01764-1 · Cited by 85
Andrades, Á., Peinado, P., Álvarez-Pérez, J. C., Sanjuán‐Hidalgo, J., García, D. J., Arenas, A. M., Matia‐González, A. M., & Medina, P. P. (2023) · Molecular Cancer · doi:10.1186/s12943-023-01736-8 · Cited by 81
Deciphering the roles of FOXO1 in human neoplasms
Jiang, S., Li, T. X., Yang, Z. P., Hu, W., & Yang, Y. (2018) · International Journal of Cancer · doi:10.1002/ijc.31338 · Cited by 66
Forconi, C. S., Cosgrove, C., Lakshmi, P. S., Nixon, C. E., Foley, J., Ong’echa, J. M., Otieno, J. A., Alter, G., Münz, C., & Moormann, A. M. (2018) · Blood Advances · doi:10.1182/bloodadvances.2017015404 · Cited by 62
Self-citationForconi, C. S., Oduor, C. I., Oluoch, P. O., Ong’echa, J. M., Münz, C., Bailey, J. A., & Moormann, A. M. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.00162 · Cited by 62
Self-citationHong, T., Parameswaran, S., Donmez, O. A., Miller, D., Forney, C. R., Lape, M., Ribeiro, M. S. J., Liang, J., Edsall, L., Magnusen, A. F., et al. (2021) · Genome Research · doi:10.1101/gr.264705.120 · Cited by 57
Ang, Z., Paruzzo, L., Hayer, K. E., Schmidt, C., Torres-Diz, M., Xu, F., Zankharia, U. S., Zhang, Y., Soldan, S. S., Zheng, S., et al. (2023) · Blood · doi:10.1182/blood.2023020400 · Cited by 54
Epstein-Barr Virus Type 2 Infects T Cells and Induces B Cell Lymphomagenesis in Humanized Mice
Coleman, C. B., Lang, J., Sweet, L. A., Smith, N. A., Freed, B. M., Pan, Z., Haverkos, B. M., Pelanda, R., & Rochford, R. A. (2018) · Journal of Virology · doi:10.1128/jvi.00813-18 · Cited by 54
Richter, J., John, K., Staiger, A. M., Rosenwald, A., Kurz, K. S., Michgehl, U., Ott, G., Franzenburg, S., Kohler, C., Finger, J., et al. (2021) · British Journal of Haematology · doi:10.1111/bjh.17874 · Cited by 48
The variant landscape and function of DDX3X in cancer and neurodevelopmental disorders
Gadek, M., Sherr, E. H., & Floor, S. N. (2023) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2023.06.003 · Cited by 44
Kaymaz, Y., Oduor, C. I., Aydemir, Ö., Luftig, M. A., Otieno, J. A., Ong’echa, J. M., Bailey, J. A., & Moormann, A. M. (2020) · Journal of Virology · doi:10.1128/jvi.02007-19 · Cited by 37
Self-citationA Survey of Reported Disease-Related Mutations in the MRE11-RAD50-NBS1 Complex
Rahman, S., Canny, M. D., Buschmann, T. A., & Latham, M. P. (2020) · Cells · doi:10.3390/cells9071678 · Cited by 35
Wist, M., Meier, L., Gutman, O., Haas, J., Endres, S., Zhou, Y., Rösler, R., Wiese, S., Stilgenbauer, S., Hobeika, E., et al. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.011946 · Cited by 34
Burkitt Lymphomas Evolve to Escape Dependencies on Epstein-Barr Virus
Hutcheson, R., Chakravorty, A. “., & Sugden, B. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.606412 · Cited by 33
Functional Implications of Epstein-Barr Virus Lytic Genes in Carcinogenesis
Yap, L. F., Wong, A. K. C., Paterson, I. C., & Young, L. S. (2022) · Cancers · doi:10.3390/cancers14235780 · Cited by 33
Zhou, P., Blain, A. E., Newman, A. M., Zaka, M., Chagaluka, G., Adlar, F. R., Offor, U. T., Broadbent, C., Chaytor, L., Whitehead, A., et al. (2019) · Blood Advances · doi:10.1182/bloodadvances.2018029546 · Cited by 32
Integrative microRNA and mRNA deep-sequencing expression profiling in endemic Burkitt lymphoma
Oduor, C. I., Kaymaz, Y., Chelimo, K., Otieno, J. A., Ong’echa, J. M., Moormann, A. M., & Bailey, J. A. (2017) · BMC Cancer · doi:10.1186/s12885-017-3711-9 · Cited by 29
Self-citationHuman and Epstein-Barr Virus miRNA Profiling as Predictive Biomarkers for Endemic Burkitt Lymphoma
Oduor, C. I., Movassagh, M., Kaymaz, Y., Chelimo, K., Otieno, J. A., Ong’echa, J. M., Moormann, A. M., & Bailey, J. A. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.00501 · Cited by 28
Self-citationReframing Burkitt lymphoma: virology not epidemiology defines clinical variants
Rochford, R. A. (2021) · Annals of Lymphoma · doi:10.21037/aol-21-18 · Cited by 27
Wang, X., Wu, F., Deng, Y., Chai, J., Zhang, Y., He, G., & Li, X. (2021) · International Journal of Oncology · doi:10.3892/ijo.2021.5286 · Cited by 27
Malaria and Cancer: a critical review on the established associations and new perspectives
Ellis, T., Eze, E., & Raimi‐Abraham, B. T. (2021) · Infectious Agents and Cancer · doi:10.1186/s13027-021-00370-7 · Cited by 25
Genetic errors of immunity distinguish pediatric nonmalignant lymphoproliferative disorders
Forbes, L. R., Eckstein, O. S., Gulati, N., Peckham‐Gregory, E. C., Ozuah, N. W., Lubega, J., El‐Mallawany, N. K., Agrusa, J. E., Poli, M. C., Vogel, T. P., et al. (2021) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2021.07.015 · Cited by 25
Phospholipase Cγ2 regulates endocannabinoid and eicosanoid networks in innate immune cells
Jing, H., Reed, A., Ulanovskaya, O. A., Grigoleit, J.-S., Herbst, D. M., Henry, C. L., Li, H., Barbas, S., Germain, J., Masuda, K., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2112971118 · Cited by 24
Al‐Khreisat, M. J., Ismail, N. H., Tabnjh, A. K., Hussain, F. A., Yusoff, A. A. M., Johan, M. F., & Islam, M. A. (2023) · Diagnostics · doi:10.3390/diagnostics13122068 · Cited by 23
Hatayama, Y., Hashimoto, Y., & Motokura, T. (2020) · Journal of International Medical Research · doi:10.1177/0300060520972880 · Cited by 21
Salmerón‐Villalobos, J., de Anta, N. C., Guerra‐García, P., Ramis-Zaldivar, J. E., López‐Guerra, M., Mato, S., Colomer, D., Diaz-Crespo, F. J., Menárguez, J., Garrido‐Pontnou, M., et al. (2023) · Blood · doi:10.1182/blood.2022019543 · Cited by 21
Frequent mutations of FBXO11 highlight BCL6 as a therapeutic target in Burkitt lymphoma
Pighi, C., Cheong, T.-C., Compagno, M., Patrucco, E., Arigoni, M., Olivero, M., Wang, Q., López, C., Bernhart, S. H., Grande, B. M., et al. (2021) · Blood Advances · doi:10.1182/bloodadvances.2021005682 · Cited by 19
The distribution of cancer cases in Somalia
Baş, Y., Hassan, H. A., Adıgüzel, C., Bulur, O., Ibrahim, İ. A., & Soydan, S. (2017) · Seminars in Oncology · doi:10.1053/j.seminoncol.2017.10.007 · Cited by 19
Fang, H., Wang, W., & Medeiros, L. J. (2024) · Human Pathology · doi:10.1016/j.humpath.2024.105703 · Cited by 18
Solares, S., León, J., & García-Gutiérrez, L. (2024) · Cancers · doi:10.3390/cancers16244212 · Cited by 18
Incrocci, R., Toro, R. M. D., Devitt, G., Salimian, M., Braich, K., & Swanson-Mungerson, M. A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25073944 · Cited by 16
Walliser, C., Wist, M., Hermkes, E., Zhou, Y., Schade, A., Haas, J., Deinzer, J., Désiré, L., Li, S. S. C., Stilgenbauer, S., et al. (2018) · Oncotarget · doi:10.18632/oncotarget.26173 · Cited by 17
Ababneh, E. I., Saad, A. M., & Crane, G. M. (2021) · Histopathology · doi:10.1111/his.14379 · Cited by 17
Chromatin-Remodeled State in Lymphoma
Liu, Y., Gonzalez, Y., & Amengual, J. E. (2019) · Current Hematologic Malignancy Reports · doi:10.1007/s11899-019-00541-9 · Cited by 16
Khan, M. A., Massey, S., Ahmad, I. S., Sadaf, S., Akhter, N., Habib, M., Mustafa, S., Deo, S. V. S., & Husain, S. A. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.842943 · Cited by 16
Sureda-Gómez, M., Iaccarino, I., Bolòs, A. D., Meyer, M., Balsas, P., Richter, J., Rodríguez, M.-L., López, C., Carreras-Caballé, M., Glaser, S., et al. (2024) · Blood · doi:10.1182/blood.2023023242 · Cited by 16
The X-Linked Helicase DDX3X Is Required for Lymphoid Differentiation and MYC-Driven Lymphomagenesis
Lacroix, M., Beauchemin, H., Fraszczak, J., Ross, J., Shooshtarizadeh, P., Chen, R., & Möröy, T. (2022) · Cancer Research · doi:10.1158/0008-5472.can-21-2454 · Cited by 16
Zhang, W., Zhu, G.-L., Xu, W., Zhang, W., Wang, H.-Z., Wang, Y., & Li, Y. (2022) · Diagnostic Pathology · doi:10.1186/s13000-022-01234-3 · Cited by 16
Kaposi Sarcoma-Associated Herpesvirus Infection and Endemic Burkitt Lymphoma
Oluoch, P. O., Oduor, C. I., Forconi, C. S., Ong’echa, J. M., Münz, C., Dittmer, D. P., Bailey, J. A., & Moormann, A. M. (2020) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiaa060 · Cited by 15
Self-citationViral and host factors drive a type 1 Epstein–Barr virus spontaneous lytic phenotype
Willard, K. A., Barry, A. P., Oduor, C. I., Ong’echa, J. M., Bailey, J. A., Moormann, A. M., & Luftig, M. A. (2023) · mBio · doi:10.1128/mbio.02204-23 · Cited by 14
Self-citationIkeda, M., Hayes, C. K., Schaller, S. J., & Longnecker, R. (2022) · Blood Advances · doi:10.1182/bloodadvances.2022007695 · Cited by 13
The RNA helicase DDX3 and its role in c-MYC driven germinal center-derived B-cell lymphoma
Lacroix, M., Beauchemin, H., Khandanpour, C., & Möröy, T. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1148936 · Cited by 14
Zanelli, M., Sanguedolce, F., Zizzo, M., Ricci, S., Bisagni, A., Palicelli, A., Fragliasso, V., Donati, B., Broggi, G., Boutas, I., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252313213 · Cited by 13
Yamazaki, T., Liu, L., Conlon, E. G., & Manley, J. L. (2020) · RNA Biology · doi:10.1080/15476286.2020.1772559 · Cited by 13
Chang, Y., Huang, Z., Quan, H., Li, H., Yang, S., Song, Y., Wang, J., Yuan, J., & Wu, C. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2022.1085632 · Cited by 12
Lakshmi, P. S., Oduor, C. I., Forconi, C. S., M’Bana, V., Bly, C. S., Gerstein, R. M., Otieno, J. A., Ong’echa, J. M., Münz, C., Luftig, M. A., et al. (2023) · Life Science Alliance · doi:10.26508/lsa.202101355 · Cited by 12
Self-citationMETTL3 regulates M6A methylation-modified EBV-pri-miR-BART3-3p to promote NK/T cell lymphoma growth
Wu, S., Wang, H., Yang, Q., Liu, Z., Du, J., Wang, L., Chen, S., Lu, Q., & Yang, D. (2024) · Cancer Letters · doi:10.1016/j.canlet.2024.217058 · Cited by 11
Subtyping Burkitt Lymphoma by DNA Methylation
Glaser, S., Wagener, R., Kretzmer, H., López, C., Baptista, M. J., Bens, S., Bernhart, S. H., Bhatia, K. G., Borkhardt, A., Elgaafary, S., et al. (2025) · Genes Chromosomes and Cancer · doi:10.1002/gcc.70042 · Cited by 11
Identification of clinical molecular targets for childhood Burkitt lymphoma
Zhang, J., Meng, L., Jiang, W., Zhang, H., Zhou, A., & Zeng, N. (2020) · Translational Oncology · doi:10.1016/j.tranon.2020.100855 · Cited by 10
Cancer Omics in Africa: Present and Prospects
Jaddaoui, I. E., Allali, I., Sehli, S., Ouldim, K., Hamdi, S., Idrissi, N. A., Nejjari, C., Amzazi, S., Bakri, Y., & Ghazal, H. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.606428 · Cited by 12
Genomic landscape of virus-associated cancers
Nam, Y., Gómez, K., Nam, Y., Khamnei, C. C., Khamnei, C., Zheng, V., Lhakhang, T. W., Casula, M., Palmieri, G., Cossu, A., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-60836-9 · Cited by 17
Genes associated with diagnosis and prognosis of Burkitt lymphoma
Doughan, A., & Salifu, S. P. (2022) · IET Systems Biology · doi:10.1049/syb2.12054 · Cited by 10
Corinaldesi, C., Holmes, A. B., Martire, G., Tosato, A., Rizzato, D., Lovisa, F., Gallingani, I., Shen, Q. “., Ferrone, L., Harris, M. H., et al. (2024) · Leukemia · doi:10.1038/s41375-024-02431-3 · Cited by 10
Molina, E., García-Gutiérrez, L., Junco, V., Pérez‐Olivares, M., de Yébenes, V. G., Blanco, R. E., Quevedo, L., Acosta, J. C., Marín, A. V., Ulgiati, D., et al. (2023) · Oncogene · doi:10.1038/s41388-023-02846-9 · Cited by 10
Rare EBV-associated B cell neoplasms of the gastrointestinal tract
Volaric, A. K., Singh, K., & Gru, A. A. (2021) · Seminars in Diagnostic Pathology · doi:10.1053/j.semdp.2021.04.004 · Cited by 10
Movassagh, M., Oduor, C. I., Forconi, C. S., Moormann, A. M., & Bailey, J. A. (2019) · Scientific Reports · doi:10.1038/s41598-019-56472-1 · Cited by 9
Self-citationCytogenomics of B-cell non-Hodgkin lymphomas: The “old” meets the “new”
Grau, M., López, C., Martín-Subero, J. I., & Beà, S. (2023) · Best Practice & Research Clinical Haematology · doi:10.1016/j.beha.2023.101513 · Cited by 8
Forconi, C., Mulama, D. H., Lakshmi, P. S., Foley, J., Otieno, J. A., Kurtis, J., Berg, L., Ong'echa, J., Münz, C., & Moormann, A. (2021) · Cancers · doi:10.3390/cancers13215375 · Cited by 7
Self-citationMurugesan, P., Begum, H., & Tangutur, A. D. (2022) · Gene · doi:10.1016/j.gene.2022.147092 · Cited by 8
Deletion of the transcriptional regulator TFAP4 accelerates c-MYC-driven lymphomagenesis
Potts, M. A., Mizutani, S., Garnham, A. L., Suen, C. S. N. L. W., Kueh, A. J., Tai, L., Pál, M., Strasser, A., & Herold, M. J. (2023) · Cell Death and Differentiation · doi:10.1038/s41418-023-01145-w · Cited by 6
Riel, M., & Johannsen, E. (2025) · Current topics in microbiology and immunology · doi:10.1007/82_2025_330 · Cited by 8
PLCG2 across human disease: genetic variants, signaling mechanisms, and clinical implications
Jiang, P., Wang, M., Zhang, C., Li, X., Wang, Z. Q., Guo, Y., Zhang, J., Yan, W., & Xi, X. (2026) · Journal of Translational Medicine · doi:10.1186/s12967-025-07632-7 · Cited by 7
Rea, B. A., Liu, Y., Maguire, A., Soma, L. A., Bacon, C. M., Bayerl, M. G., Smith, M. H., Barrett, M. T., Swerdlow, S. H., & Gibson, S. E. (2021) · Modern Pathology · doi:10.1038/s41379-021-01002-6 · Cited by 6
Burkitt Lymphoma—A Guide to Biological Features, Diagnosis and Differential Diagnosis
Anagnostopoulos, I., Zamò, A., Horn, H., Staiger, A. M., & Ott, G. (2026) · Cancers · doi:10.3390/cancers18040579 · Cited by 5
Singh, A. P., & Obiorah, I. E. (2023) · Seminars in Diagnostic Pathology · doi:10.1053/j.semdp.2023.06.002 · Cited by 5
RNA-seq research landscape in Africa: systematic review reveals disparities and opportunities
Doughan, A., Adingo, W., & Salifu, S. P. (2023) · European journal of medical research · doi:10.1186/s40001-023-01206-3 · Cited by 5
Transcriptional regulation of gene modules in Epstein-Barr virus
Lieberman, P. M. (2025) · Transcription · doi:10.1080/21541264.2025.2562704 · Cited by 5
Gurtsevitch, V., Lubenskaya, A. K., Senyuta, N. B., Dushenkina, T. E., & Smirnova, K. V. (2022) · Problems of Virology · doi:10.36233/0507-4088-120 · Cited by 5
Silencing proline-rich coiled-coil 2C inhibit the proliferation and metastasis of liver cancer cells
Zhang, K., Xu, J., & Chen, R. (2023) · Journal of Gastrointestinal Oncology · doi:10.21037/jgo-23-10 · Cited by 5
The ‘Oma’s of the Gammas—Cancerogenesis by γ-Herpesviruses
Banerjee, A., Dass, D., Mukherjee, S., Kaul, M., Harshithkumar, R., Bagchi, P., & Mukherjee, A. (2024) · Viruses · doi:10.3390/v16121928 · Cited by 5
Galli, E., D’Alò, F., Cuccaro, A., Alma, E., Maiolo, E., Brugnoletti, F., Larocca, L. M., Zollino, M., Bacigalupo, A. P., & Hohaus, S. (2020) · Mediterranean Journal of Hematology and Infectious Diseases · doi:10.4084/mjhid.2020.034 · Cited by 4
Siddiqui, S. H., Thakral, B., Aakash, F., Ok, C. Y., Tang, Z., & Medeiros, L. J. (2023) · Annals of Diagnostic Pathology · doi:10.1016/j.anndiagpath.2023.152182 · Cited by 4
Mosaic chromosomal alterations in peripheral blood leukocytes of children in sub-Saharan Africa
Zhou, W., Fischer, A., Ogwang, M. D., Luo, W., Kerchan, P., Reynolds, S. J., Tenge, C., Were, P. A., Kuremu, R. T., Wekesa, W. N., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-43881-0 · Cited by 4
Genomic landscape of virus-associated cancersPreprint
Gómez, K., Schiavoni, G., Nam, Y., Reynier, J.-B., Khamnei, C. C., Aitken, M., Palmieri, G., Cossu, A., Levine, A. J., van Noesel, C. J. M., et al. (2023) · medRxiv · doi:10.1101/2023.02.14.23285775 · Cited by 4
Dierickx, D., Keane, C., & Natkunam, Y. (2024) · Histopathology · doi:10.1111/his.15342 · Cited by 3
Pathogenesis of B-Cell Lymphoma
Wagener, R., López, C., & Siebert, R. (2019) · Springer eBooks · doi:10.1007/978-3-030-11769-6_4 · Cited by 3
Concerning data inconsistencies in Burkitt lymphoma genome study
Rushton, C. K., Dreval, K., & Morin, R. D. (2022) · Blood · doi:10.1182/blood.2022016505 · Cited by 3
Cancer Biomarkers V: Update on B-Cell Lymphoma Biomarkers
Crane, G. M. (2023) · Archives of Pathology & Laboratory Medicine · doi:10.5858/arpa.2023-0056-ra · Cited by 2
Kim, I. E., Fola, A. A., Puig, E., Maina, T. K., Hui, S. T., Ma, H., Zuckerman, K., Agwati, E. O., Leonetti, A., Crudale, R., et al. (2025) · Scientific Reports · doi:10.1038/s41598-025-94737-0 · Cited by 2
Self-citationInhibition of EgRad50 leads to impaired DNA repair in Echinococcus granulosus sensu stricto
Zhao, J., Xu, S., Du, Y., Tuniyazi, X., Liao, X., Liao, X., Jia, Y., Lü, G., & Zhao, J. (2025) · Infection Genetics and Evolution · doi:10.1016/j.meegid.2025.105855 · Cited by 2
Kim, I. E., Oduor, C. I., Stamp, J., Luftig, M. A., Moormann, A. M., Crawford, L. A., & Bailey, J. A. (2025) · International Journal of Cancer · doi:10.1002/ijc.35384 · Cited by 3
Self-citationBeauchemin, H., Dalloul, Z., Piskor, E.-M., Calderon, V., Chatr‐aryamontri, A., Bertomeu, T., & Möröy, T. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1642006 · Cited by 2
Landscape of Epstein-Barr virus gene expression and perturbations in cancerPreprint
Tang, K., Tian, Y., Xie, G., Bäckerholm, A., Holmqvist, I., Vracar, D., Lin, J., Carlsten, J. O. P., Abrahamsson, S., Liu, Z., et al. (2024) · Research Square · doi:10.21203/rs.3.rs-3911441/v1 · Cited by 2
Evaluation of KIR3DL1/KIR3DS1 allelic polymorphisms in Kenyan children with endemic Burkitt lymphoma
Muriuki, B. M., Forconi, C. S., Kirwa, E. K., Maina, T. K., Ariera, B., Bailey, J. A., Ghansah, A., Moormann, A. M., & Ong’echa, J. M. (2023) · PLoS ONE · doi:10.1371/journal.pone.0275046 · Cited by 1
Self-citationUpdate: The molecular spectrum of virus-associated high-grade B-cell non-Hodgkin lymphomas
Witte, H. M., Künstner, A., & Gebauer, N. (2024) · Blood Reviews · doi:10.1016/j.blre.2024.101172 · Cited by 1
Gao, H., Wang, L., Lei, Z., Fang, Y., Ding, M., Guo, S., Chen, J., Chen, Z., & Wang, G. (2026) · Discover Oncology · doi:10.1007/s12672-026-04523-1 · Cited by 1
Malaria driven mechanisms shaping cancer risk and aggressiveness in African populations
Udobi, M. E., Bella-Omunagbe, M., Effiong, P. E., Afolabi, I. S., & Chinedu, S. N. (2026) · Cancer Treatment and Research Communications · doi:10.1016/j.ctarc.2026.101210 · Cited by 1
Metadata
- Authors
- Kaymaz, Y., Oduor, C. I., Yu, H., Otieno, J. A., Ong'echa, J. M., Moormann, A. M., & Bailey, J. A.
- Affiliations
- University of Massachusetts Chan Medical School (US)
- Maseno University (KE)
- Ministry of Health (KE)
- 2Center for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya.
- Corresponding author
- Bailey, Jeffrey A.
- Venue
- Molecular Cancer Research
- Published
- 2017-05-01
- Volume
- 15
- Issue
- 5
- Pages
- 563-576
- ISSN
- 1541-7786 (ISSN-L)
- 1557-3125
- PMC
- PMC5471630
- OpenAlex
- W2580872164
- Cited by
- 120
- References
- 65
- Citations by year
- 2026: 10 · 2025: 11 · 2024: 17 · 2023: 23 · 2022: 16 · 2021: 14 · 2020: 11 · 2019: 9 · 2018: 4 · 2017: 5
- FWCI
- 3.50
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Molecular Cancer Research (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- The Journal of the American Medical Association (JAMA) Network (American Medical Association) (submittedVersion)
- Funders
- National Institutes of Health (UL1TR001453, UL1TR000161)
- National Cancer Institute (R01CA134051, R01CA189806)
- National Institute of Allergy and Infectious Diseases (R01AI099473)
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Medicine › Oncology › Viral-associated cancers and disorders
- Health Sciences › Medicine › Pathology and Forensic Medicine › Lymphoma Diagnosis and Treatment
- Health Sciences › Medicine › Clinical Neurology › CNS Lymphoma Diagnosis and Treatment
- Keywords
- endemic Burkitt lymphoma, sporadic Burkitt lymphoma, Epstein-Barr virus, transcriptome, mutational profiling, immunoproteasome, PSMB9, TFAP4, MSH6, prognostic factors, pediatric lymphoma
- MeSH terms
- Adolescent, Burkitt Lymphoma, Child, Child, Preschool, Herpesvirus 4, Human, Female, Humans, Kenya, Male, Mutation, Genome, Viral, Sequence Analysis, RNA, Endemic Diseases, Epstein-Barr Virus Infections, Gene Expression Profiling, Gene Regulatory Networks, Mutation Rate
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
