The DOI matches its Crossref record; 57 of the 57 references it cites were found in a registry or an index.
ceRNA Cross-Talk in Cancer: When ce-bling Rivalries Go Awry
Open accessAbstract
The cancer transcriptome is characterized by aberrant expression of both protein-coding and noncoding transcripts. Similar to mRNAs, a significant portion of the noncoding transcriptome, including long noncoding RNAs and pseudogenes, harbors microRNA (miRNA)-response elements (MRE). The recent discovery of competitive endogenous RNAs (ceRNA), natural decoys that compete for a common pool of miRNAs, provides a framework to systematically functionalize MRE-harboring noncoding RNAs and integrate them with the protein-coding RNA dimension in complex ceRNA networks. Functional interactions in ceRNA networks aid in coordinating a number of biologic processes and, when perturbed, contribute to disease pathogenesis. In this review, we discuss recent discoveries that implicate natural miRNA decoys in the development of cancer. Significance: Cross-talk between ceRNAs through shared miRNAs represents a novel layer of gene regulation that plays important roles in the physiology and development of diseases such as cancer. As cross-talk can be predicted on the basis of the overlap of miRNA-binding sites, we are now one step closer to a complete functionalization of the human transcriptome, especially the noncoding space. Cancer Discov; 3(10); 1113–21. ©2013 AACR.
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Self-citation
Cited by
The role and mechanisms of action of microRNAs in cancer drug resistance
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Metadata
- Authors
- Karreth, F. A., & Pandolfi, P. P.
- Venue
- Cancer Discovery
- Published
- 2013-10-01
- Volume
- 3
- Issue
- 10
- Pages
- 1113-1121
- ISSN
- 2159-8274 (ISSN-L)
- 2159-8290
- OpenAlex
- W2160068229
- Cited by
- 851
- References
- 57
- FWCI
- 7.86
- Type
- journal article
- Language
- en
- Open access
- green
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