The DOI matches its Crossref record.
Positive Results for Tazemetostat in Follicular Lymphoma
Abstract
A recently reported clinical trial indicates that the EZH2 inhibitor tazemetostat is effective against relapsed or refractory follicular lymphoma. Three of 28 patients with EZH2 mutations had complete responses, and 17 had partial responses.
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“More recently, the arginine methyltransferase PRMT5 has been implicated in driving neoplastic growth of multiple tumours including B cell lymphoma, multiple myeloma, breast cancer and glioblastoma 171-178 .”
From The roles of DNA, RNA and histone methylation in ageing and cancer (2019) · cites this paper as [171]
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The roles of DNA, RNA and histone methylation in ageing and cancer
Michalak, E. M., Burr, M. L., Bannister, A. J., & Dawson, M. A. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0143-1 · Cited by 549
Carbone, A., Roulland, S., Gloghini, A., Younes, A., von Keudell, G., López‐Guillermo, A., & Fitzgibbon, J. (2019) · Nature Reviews Disease Primers · doi:10.1038/s41572-019-0132-x · Cited by 303
Bugide, S., Gupta, R., Green, M. R., & Wajapeyee, N. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2102718118 · Cited by 86
B cells in chronic graft-versus-host disease
McManigle, W. C., Youssef, A., & Sarantopoulos, S. (2019) · Human Immunology · doi:10.1016/j.humimm.2019.03.003 · Cited by 81
Li, C., Wang, Y., Gong, Y., Zhang, T., Huang, J., Tan, Z. W., & Xue, L. (2021) · Clinical Epigenetics · doi:10.1186/s13148-021-01045-1 · Cited by 82
Murashima, A., Shinjo, K., Katsushima, K., Onuki, T., Kondoh, Y., Osada, H., Kagaya, N., Shin‐ya, K., Kimurâ, H., Yoshida, M., et al. (2019) · The Journal of Biochemistry · doi:10.1093/jb/mvz007 · Cited by 12
Iizuka, T., Ishikawa, A., Motoi, N., et al. (2025) · Human Pathology · doi:10.1016/j.humpath.2025.105823 · Cited by 1
Nouvelles stratégies thérapeutiques dans le traitement du gliome infiltrant du tronc cérébral
Herrault, G. (2024) · theses.fr (ABES) · doi:10.70675/539ee639z4f77z47b3z903ez909ec614384d
Metadata
- Venue
- Cancer Discovery
- Published
- 2018-08-01
- Volume
- 8
- Issue
- 8
- Pages
- OF3-OF3
- ISSN
- 2159-8274 (ISSN-L)
- 2159-8290
- OpenAlex
- W4241004197
- Cited by
- 8
- References
- 0
- Citations by year
- 2025: 1 · 2024: 1 · 2021: 2 · 2019: 4
- FWCI
- 1.15
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cancer Discovery (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Lymphoma Diagnosis and Treatment
- Health Sciences › Medicine › Hematology › Chronic Lymphocytic Leukemia Research
- Health Sciences › Medicine › Dermatology › Cutaneous lymphoproliferative disorders research
- Keywords
- tazemetostat, follicular lymphoma, EZH2 inhibitors, EZH2 mutation, relapsed/refractory lymphoma, complete response, partial response, clinical trial results
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