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Gut Microbiota May Mediate AEs
Abstract
In patients with melanoma and in in vivo models, gut colonization by Bacteroides intestinalis is associated with increased immune-related adverse events, such as colitis, resulting from treatment with combined immune checkpoint blockade.
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In the citing paper
“For example, recolonization of Enterobacteriaceae during ICI treatment has been implicated in increasing intestinal inflammatory toxicity through the expression of inflammatory cytokine IL-1β153.”
From Microbiome meets immunotherapy: unlocking the hidden predictors of immune checkpoint inhibitors (2025) · cites this paper as [153]
Citations
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Cited by 3
Metadata
- Venue
- Cancer Discovery
- Published
- 2021-09-01
- Volume
- 11
- Issue
- 9
- Pages
- 2118-2118
- ISSN
- 2159-8274 (ISSN-L)
- 2159-8290
- OpenAlex
- W4206353527
- Cited by
- 3
- References
- 0
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 1
- FWCI
- 0.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cancer Discovery (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Bacterial Cancer Therapy
- Keywords
- gut microbiota, Bacteroides intestinalis, immune-related adverse events, melanoma, immune checkpoint blockade, colitis, intestinal colonization, cancer immunotherapy
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Gut Microbiota May Mediate AEs. https://app.cochat.ai/papers/10.1158/2159-8290.cd-nb2021-0371
- The paper
- Gut Microbiota May Mediate AEs. (2021). Cancer Discovery. https://doi.org/10.1158/2159-8290.cd-nb2021-0371
