The immunological synapse
Open accessAbstract
The molecular interactions underlying regulation of the immune response take place in a nanoscale gap between T cells and antigen-presenting cells, termed the immunological synapse. If these interactions are regulated appropriately, the host is defended against a wide range of pathogens and deranged host cells. If these interactions are disregulated, the host is susceptible to pathogens or tumor escape at one extreme and autoimmunity at the other. Strategies targeting the synapse have helped to establish immunotherapy as a mainstream element in cancer treatment. This Masters' primer will cover the basics of the immunological synapse and some of the applications to tumor immunology. Cancer Immunol Res; 2(11); 1023–33. ©2014 AACR.
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This architecture resembles immunological and neuronal synapses, suggesting the existence of a pigmentary synapse through which keratinocytes and melanocytes can communicate to control the production and transfer of melanin in the epidermis.
“This architecture resembles the well-known immunological and neuronal synapses [ 126 , 127 ], suggesting the existence of a pigmentary synapse through which keratinocytes and melanocytes can communicate to control the production and transfer of melanin in the epidermis.”
From Melanin's Journey from Melanocytes to Keratinocytes: Uncovering the Molecular Mechanisms of Melanin Transfer and Processing (2023) · cites this paper as [126]
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References 333 · Cited by 502
- Authors
- Dustin, M. L.
- Affiliations
- University of Oxford (GB)
- Corresponding author
- Dustin, Michael L.
- ORCID
- Dustin, Michael L.
- Venue
- Cancer Immunology Research
- Published
- 2014-11-01
- Volume
- 2
- Issue
- 11
- Pages
- 1023-1033
- ISSN
- 2326-6066 (ISSN-L)
- 2326-6074
- PMC
- PMC4692051
- OpenAlex
- W1816311090
- Cited by
- 502
- References
- 333
- Citations by year
- 2026: 52 · 2025: 57 · 2024: 64 · 2023: 50 · 2022: 62 · 2021: 49 · 2020: 51 · 2019: 36 · 2018: 33 · 2017: 20 · 2016: 14 · 2015: 5 · 2014: 1 · 2013: 2
- FWCI
- 1.30
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cancer Immunology Research (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Wellcome Trust (100262, 100262/Z/12/Z)
- National Institute of Allergy and Infectious Diseases (R01AI043542, R01AI055037, R21AI055037, AI043542, R01AI044931, R37AI043542, AI55037)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Keywords
- immunological synapse, T cell-antigen-presenting cell interaction, T cell activation, immune regulation, autoimmunity, tumor escape, cancer immunotherapy, tumor immunology
- MeSH terms
- Animals, Humans, Immunotherapy, Neoplasms, Tumor Escape, Immunological Synapses
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