Association of Probiotic Clostridium butyricum Therapy with Survival and Response to Immune Checkpoint Blockade in Patients with Lung Cancer

Tomita, Yusuke; Ikeda, Tokunori; Sakata, Shinya; Saruwatari, Koichi; Sato, Ryo; Iyama, Shinji; Jodai, Takayuki; Akaike, Kimitaka; Ishizuka, Shiho; Saeki, Sho; Sakagami, Takuro

doi:10.1158/2326-6066.cir-20-0051

Association of Probiotic Clostridium butyricum Therapy with Survival and Response to Immune Checkpoint Blockade in Patients with Lung Cancer

Gut dysbiosis caused by antibiotics impairs response to immune checkpoint blockade (ICB). Gut microbiota is becoming an attractive therapeutic target for cancer. The Clostridium butyricum MIYAIRI 588 strain is a probiotic therapy used to improve symptoms related to antibiotic-induced dysbiosis in…