The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Aminoglycoside Antibiotics
Abstract
In the 50 years since their discovery, the aminoglycoside antibiotics have seen unprecedented use. Discovered in the 1940s, they were the long-sought remedy for tuberculosis and other serious bacterial infections. The side effects of renal and auditory toxicity, however, led to a decline of their use in most countries in the 1970s and 1980s. Nevertheless, today the aminoglycosides are still the most commonly used antibiotics worldwide thanks to the combination of their high efficacy with low cost. This review first summarizes the history, chemistry, antibacterial actions and acute side effects of the drugs. It then details the pathophysiology of aminoglycoside ototoxicity including experimental and clinical observations, risk factors and incidence. Pharmacokinetics, cellular actions and our current understanding of the underlying molecular mechanisms of ototoxicity are discussed at length. The review concludes with recent advances towards therapeutic intervention to prevent aminoglycoside ototoxicity.
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Citations
Cites
Song, B.-B., & Schacht, J. (1996) · Hearing Research · doi:10.1016/0378-5955(96)00003-2 · Cited by 157
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Metadata
- Authors
- Forge, A., & Schacht, J.
- Venue
- Audiology and Neurotology
- Publisher
- S. Karger AG
- Published
- 2000
- Volume
- 5
- Issue
- 1
- Pages
- 3-22
- ISSN
- 1420-3030 (ISSN-L)
- 1421-9700
- OpenAlex
- W4246398711
- Cited by
- 595
- References
- 1
- FWCI
- 8.18
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
