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Pathogenesis of Renal Failure in Rhabdomyolysis: The Role of Myoglobin
Abstract
Rhabdomyolysis causes renal dysfunction associated with renal vasoconstriction, tubular toxicity and luminal obstruction. There is now accumulating evidence that renal injury, caused by lipid peroxidation, is important in the pathogenesis of renal failure. The proposed central role of free iron in this process is examined. Current data have shown that the heme center of myoglobin can initiate lipid peroxidation and renal injury without invoking release of free iron, and this process is due to redox cycling of the heme group from ferrous to ferric and to ferryl oxidation states. Alkaline conditions prevent myoglobin-induced lipid peroxidation by stabilizing the reactive ferryl myoglobin complex. This review explores the evidence for each of these mechanisms.
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Citations
Cited by
Free heme toxicity and its detoxification systems in human
Kumar, S., & Bandyopadhyay, U. (2005) · Toxicology Letters · doi:10.1016/j.toxlet.2005.03.004 · Cited by 852
VANHOLDER, R., SEVER, M. S. D. D., EREK, E., & LAMEIRE, N. (2000) · Journal of the American Society of Nephrology · doi:10.1681/asn.v1181553 · Cited by 657
Acute kidney injury due to rhabdomyolysis and renal replacement therapy: a critical review
Petejova, N., & Martinek, A. (2014) · Critical Care · doi:10.1186/cc13897 · Cited by 444
Redox Reactions of Hemoglobin and Myoglobin: Biological and Toxicological Implications
Alayash, A. I., Patel, R. P., & Cashon, R. E. (2001) · Antioxidants & Redox Signaling · doi:10.1089/152308601300185250 · Cited by 243
What Is Responsible for the Initiating Chemistry of Iron-Mediated Lipid Peroxidation: An Update
Cheng, Z., & Li, Y. (2007) · Chemical Reviews · doi:10.1021/cr040077w · Cited by 211
Metadata
- Authors
- Holt, S., & Moore, K.
- Venue
- Nephron Experimental Nephrology
- Publisher
- S. Karger AG
- Published
- 2000-03-15
- Volume
- 8
- Issue
- 2
- Pages
- 72-76
- ISSN
- 1660-2129 (ISSN-L)
- OpenAlex
- W2078601157
- Cited by
- 195
- References
- 0
- FWCI
- 7.85
- Type
- journal article
- Language
- en
- Open access
- closed
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