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Glutathione S-Transferase Polymorphisms and Their Biological Consequences
Abstract
Two supergene families encode proteins with glutathione S-transferase (GST) activity: the family of soluble enzymes comprises at least 16 genes; the separate family of microsomal enzymes comprises at least 6 genes. These two GST families are believed to exert a critical role in cellular protection against oxidative stress and toxic foreign chemicals. They detoxify a variety of electrophilic compounds, including oxidized lipid, DNA and catechol products generated by reactive oxygen species-induced damage to intracellular molecules. An increasing number of GST genes are being recognized as polymorphic. Certain alleles, particularly those that confer impaired catalytic activity (e.g. GSTM1*0, GSTT1*0), may be associated with increased sensitivity to toxic compounds. GST polymorphisms may be disease modifying; for example, in subgroups of patients with basal cell carcinoma or bronchial hyper-responsiveness, certain GST appear to exert a statistically significant and biologically relevant impact on disease susceptibility.
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Cites
The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation
Ricote, M., Li, A. C., Willson, T. M., Kelly, C. J., & Glass, C. K. (1998) · Nature · doi:10.1038/34178 · Cited by 3,525
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SHEEHAN, D., MEADE, G., FOLEY, V. M., & DOWD, C. A. (2001) · Biochemical Journal · doi:10.1042/0264-6021:3600001 · Cited by 3,057
Glucosinolates, isothiocyanates and human health
Traka, M., & Mithen, R. (2009) · Phytochemistry Reviews · doi:10.1007/s11101-008-9103-7 · Cited by 490
Sex Differences in Cancer: Epidemiology, Genetics and Therapy
Kim, H.-I., Lim, H., & Moon, A. (2018) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2018.103 · Cited by 315
Gilliland, F. D., Li, Y.-F., Dubeau, L., Berhane, K., Avol, E., McConnell, R., Gauderman, W. J., & Peters, J. M. (2002) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.2112064 · Cited by 289
Role of glutathione in neuroprotective effects of mood stabilizing drugs lithium and valproate
Cui, J., Shao, L., Young, L. T., & Wang, J.-F. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2006.11.010 · Cited by 160
Metadata
- Authors
- Hayes, J. D., & Strange, R. C.
- Venue
- Pharmacology
- Publisher
- S. Karger AG
- Published
- 2000
- Volume
- 61
- Issue
- 3
- Pages
- 154-166
- ISSN
- 0031-7012 (ISSN-L)
- 1423-0313
- OpenAlex
- W1976346227
- Cited by
- 1,001
- References
- 1
- FWCI
- 9.35
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
