The Scaling of White Matter to Gray Matter in Cerebellum and Neocortex
Abstract
It is known that the white matter of neocortex increases disproportionately with brain size. However, relatively few measurements have been made of white matter/gray matter scaling in the cerebellum. We present data on the volumes of white and gray matter in both structures, taken from 45 species of mammals. We find a scaling exponent of 1.13 for cerebellum and 1.28 for neocortex. The 95% confidence intervals for our estimates of these two exponents do not overlap. This difference likely reflects differences in the connectivity and/or micro-structure of white matter in the two regions.
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In the cerebellum, there is a much less steep increase in white matter volume with overall size than in the neocortex.
“In the cerebellum, there is a much less steep increase in white matter volume with overall size (figure 1b; and see [47]).”
From Embodied cognitive evolution and the cerebellum (2012) · cites this paper as [47]
Larger cortices are increasingly made up of white rather than grey matter.
“larger cortices are increasingly made up of white rather than grey matter (figure 1a, see also [46,47]).”
From Embodied cognitive evolution and the cerebellum (2012) · cites this paper as [47]
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References 17 · Cited by 81
- Authors
- Bush, E. C., & Allman, J. M.
- Affiliations
- California Institute of Technology (US)
- ORCID
- Bush, Eliot C.
- Venue
- Brain, Behavior and Evolution
- Publisher
- S. Karger AG
- Published
- 2003
- Volume
- 61
- Issue
- 1
- Pages
- 1-5
- ISSN
- 0006-8977 (ISSN-L)
- 1421-9743
- OpenAlex
- W2021032796
- Cited by
- 81
- References
- 17
- Citations by year
- 2025: 4 · 2024: 2 · 2023: 2 · 2022: 2 · 2021: 2 · 2019: 3 · 2018: 2 · 2017: 2 · 2016: 6 · 2015: 2 · 2014: 3 · 2013: 3 · 2012: 7
- FWCI
- 6.95
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Behavior and Evolution (publishedVersion)
- PubMed (publishedVersion)
- CaltechAUTHORS (California Institute of Technology) (submittedVersion)
- Funders
- National Institutes of Health (5r01ey011759-05)
- National Eye Institute (EY11759)
- National Institute of General Medical Sciences (T32GM007737, GM-07737)
- Topics
- Social Sciences › Psychology › Social Psychology › Primate Behavior and Ecology
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Physical Sciences › Earth and Planetary Sciences › Paleontology › Evolution and Paleontology Studies
- Keywords
- white matter, gray matter, cerebellum, neocortex, brain size scaling, scaling exponents, mammalian brain, white matter volume, brain microstructure, brain connectivity
- MeSH terms
- Animals, Behavior, Animal, Cerebellum, Mammals, Neocortex
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