Neocortical Glial Cell Numbers in Alzheimer’s Disease
Abstract
Most studies agree that specific regions of the hippocampus and specific subcortical regions show neuronal loss in Alzheimer's disease (AD). The aim of the study was to use design-based stereological methods to obtain an estimate of the total glial cell population in 14 AD cases and 20 controls to determine whether brains from AD patients have a different number of neocortical glial cells than controls. The mean total number of neocortical glial cells was 25.9 x 10(9) for the AD group and 29.1 x 10(9) for the control group, 2p = 0.18. The mean total number of neocortical neurons was 18.9 x 10(9) for the AD group and 21.2 x 10(9) for the control group, 2p = 0.059. Estimates of the sum of all glial cells and neurons in the neocortex were in the order of 50 billion cells with a glia to neuron ratio of 1.37 in both groups.
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Pelvig et al. identified microglia based on morphology and quantified them using stereology, but found no difference in the total number of cells in the neocortex.
“In contrast, Pelvig et al.122 also identified microglia based on morphology and quantified them using stereology, but found no difference in the total number of cells in the neocortex.”
From Markers of microglia in post-mortem brain samples from patients with Alzheimer’s disease: a systematic review (2018) · cites this paper as [122]
The three stereology studies that counted all microglia, identified by either Iba1 or morphology, reported no differences in total microglial counts in AD relative to control samples, whereas increases were noted in the number of cells positive for activation-associated markers MHCII, CD68 and CD33.
“Interestingly, the three stereology studies that counted all microglia, identified by either Iba1 or morphology, reported no differences in total microglial counts in AD relative to control samples,54, 122, 70 whereas increases were noted in the number of cells positive for activation-associated markers MHCII, CD68 and CD33.54, 70, 83, 84”
From Markers of microglia in post-mortem brain samples from patients with Alzheimer’s disease: a systematic review (2018) · cites this paper as [122]
Secreted Aβ40 and Aβ42 during HN cell aging has implications in the development of Aβ-related neuropathology and resembles Aβ deposition during brain aging and in AD.
“Secreted Aβ40 and Aβ42 during HN cell aging has implications in the development of Aβ-related neuropathology and resembles Aβ deposition during brain aging and in AD (Crapper et al., 1975; Pelvig et al., 2003; Terry, 1983).”
From Docosanoids and elovanoids from omega-3 fatty acids are pro-homeostatic modulators of inflammatory responses, cell damage and neuroprotection (2018) · cites this paper as Pelvig et al., 2003
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References 28 · Cited by 81
- Authors
- Pelvig, D. P., Pakkenberg, H., Regeur, L., Oster, S., & Pakkenberg, B.
- Affiliations
- Bispebjerg Hospital (DK)
- ORCID
- Pakkenberg, Bente
- Venue
- Dementia and Geriatric Cognitive Disorders
- Publisher
- S. Karger AG
- Published
- 2003
- Volume
- 16
- Issue
- 4
- Pages
- 212-219
- ISSN
- 1420-8008 (ISSN-L)
- 1421-9824
- OpenAlex
- W2074424606
- Cited by
- 81
- References
- 28
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 3 · 2023: 3 · 2022: 5 · 2021: 3 · 2020: 4 · 2019: 2 · 2018: 4 · 2017: 2 · 2016: 6 · 2015: 3 · 2014: 2 · 2013: 3 · 2012: 7
- FWCI
- 1.34
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Dementia and Geriatric Cognitive Disorders (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Johns Hopkins University
- National Institutes of Health
- National Institute on Aging (P50AG005146, AG 05146)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- Alzheimer's disease, neocortex, glial cells, neuronal loss, stereology
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Cell Count, Female, Humans, Male, Middle Aged, Neuroglia, Cell Death, Neocortex
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