High iron and low ascorbic acid concentrations in the dermis of atopic dermatitis patients
Abstract
BACKGROUND: Atopic dermatitis (AD) is a chronic inflammatory skin disease in which reactive oxygen species (ROS) may be involved. Iron catalyses ROS formation and ascorbic acid (AA) scavenges these species. OBJECTIVE: The aim of this work was to determine iron and AA levels in AD patients' dermis and to compare their concentrations with those of healthy volunteers' dermis. METHODS: Five AD patients and 5 healthy subjects (controls) were enrolled in this study. Iron and AA were collected from human dermis by microdialysis and assessed by atomic absorption spectrometry and gas chromatography-mass spectrometry, respectively. RESULTS: The AD dermis demonstrated higher iron concentrations (44.3 +/- 4.6 microg/l) compared to controls (21.8 +/- 1.2 microg/l) as well as a significantly lower concentration of AA (46.7 +/- 0.6 vs. 176.8 +/- 14.5 microg/ml, respectively). CONCLUSION: These results suggest that iron and AA dermis levels could be indicators of inflammatory tissues and might be implicated in dermatological diseases such as AD.
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In patients suffering from atopic dermatitis, the plasma vitamin C levels are normal, but their dermis contains approximately four times less vitamin C.
“In patients suffering from atopic dermatitis, the plasma vitamin C levels are normal, but their dermis contains approximately four times less vitamin C [176].”
From Vitamin C-Sources, Physiological Role, Kinetics, Deficiency, Use, Toxicity, and Determination (2021) · cites this paper as [176]
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References 20 · Cited by 34
- Authors
- Leveque, N., Robin, S., Muret, P., Mac-Mary, S., Makki, S., & Humbert, P.
- Affiliations
- Université de Franche-Comté (FR)
- Venue
- Dermatology
- Publisher
- S. Karger AG
- Published
- 2003
- Volume
- 207
- Issue
- 3
- Pages
- 261-264
- ISSN
- 1018-8665 (ISSN-L)
- 1421-9832
- OpenAlex
- W2089385261
- Cited by
- 34
- References
- 20
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2023: 1 · 2022: 3 · 2021: 4 · 2019: 6 · 2018: 2 · 2017: 1 · 2016: 2 · 2014: 2 · 2013: 1 · 2012: 1
- FWCI
- 1.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Dermatology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
- Health Sciences › Medicine › Dermatology › Contact Dermatitis and Allergies
- Keywords
- atopic dermatitis, iron, vitamin C, dermis, reactive oxygen species, oxidative stress, inflammatory markers, microdialysis, skin inflammation
- MeSH terms
- Adult, Ascorbic Acid, Dermatitis, Atopic, Female, Humans, Iron, Male, Middle Aged, Probability, Prognosis, Sensitivity and Specificity, Severity of Illness Index, Biomarkers, Case-Control Studies, Statistics, Nonparametric, Dermis
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