The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Transforming Growth Factor-β Signaling during Epithelial-Mesenchymal Transformation: Implications for Embryogenesis and Tumor Metastasis
Abstract
The molecular mechanisms of epithelial-mesenchymal transformation (EMT) have long been studied to gain a greater understanding of this distinct change in cellular morphology. Early studies of the developing embryo have designated the involvement of Wnt signaling in EMT, through an activated complex of the lymphoid-enhancing factor-1 (LEF-1) transcription factor and the cell adhesion molecule β-catenin. However, more recent studies have implicated a significant role of the transforming growth factor-β (TGF-β) in causing EMT in both development and pathology. The ability of TGF-β isoforms to signal through a variety of molecules such as Smads, phosphatidylinositol 3-kinase (PI3K), and mitogen-activated protein kinase (MAPK) creates an incredible complexity as to their role in this transition. Here we assess the biochemical signaling pathways of TGF-β and their potential cross-interaction with traditional Wnt signaling molecules to bring about EMT during embryogenesis and tumor metastasis.
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Cites
TGF-β Signaling in Tumor Suppression and Cancer Progression
Derynck, R., Akhurst, R. J., & Balmain, A. (2001) · Nature Genetics · doi:10.1038/ng1001-117 · Cited by 2,275
Gaullier, J.-M., Simonsen, A., D'Arrigo, A., Bremnes, B., Stenmark, H., & Aasland, R. (1998) · Nature · doi:10.1038/28767 · Cited by 553
Cited by
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Kalluri, R., & Weinberg, R. A. (2009) · Journal of Clinical Investigation · doi:10.1172/jci39104 · Cited by 10,196
Signaling mechanisms of the epithelial-mesenchymal transition
Gonzalez, D. M., & Medici, D. (2014) · Science Signaling · doi:10.1126/scisignal.2005189 · Cited by 1,721
Embryonic and tumorigenic pathways converge via Nodal signaling: role in melanoma aggressiveness
Topczewska, J. M., Postovit, L.-M., Margaryan, N. V., Sam, A., Hess, A. R., Wheaton, W. W., Nickoloff, B. J., Topczewski, J., & Hendrix, M. J. C. (2006) · Nature Medicine · doi:10.1038/nm1448 · Cited by 438
Inflammation: A driving force speeds cancer metastasis
Wu, Y., & Zhou, B. P. (2009) · Cell Cycle · doi:10.4161/cc.8.20.9699 · Cited by 327
Epithelial-mesenchymal Transition and Cell Invasion
Son, H.-J., & Moon, A. (2010) · Toxicological Research · doi:10.5487/tr.2010.26.4.245 · Cited by 320
Metadata
- Authors
- Nawshad, A., LaGamba, D., Polad, A., & Hay, E. D.
- Venue
- Cells Tissues Organs
- Publisher
- S. Karger AG
- Published
- 2005
- Volume
- 179
- Issue
- 1-2
- Pages
- 11-23
- ISSN
- 1422-6405 (ISSN-L)
- 1422-6421
- OpenAlex
- W2000099153
- Cited by
- 327
- References
- 2
- FWCI
- 5.88
- Type
- journal article
- Language
- en
- Open access
- closed
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- Nawshad, A., LaGamba, D., Polad, A., & Hay, E. D. (2005). Transforming Growth Factor-β Signaling during Epithelial-Mesenchymal Transformation: Implications for Embryogenesis and Tumor Metastasis. Cells Tissues Organs. https://doi.org/10.1159/000084505
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