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Cited by 127Diabetes Treatment and ManagementElectrolyte and hormonal disordersRegulation of Appetite and Obesity

The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.

Glucagon-Like Peptide-1 Is Involved in Sodium and Water Homeostasis in Humans

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Gutzwiller, Jean-Pierre, Hruz, Petr, Huber, Andreas R., Hamel, Christian, Zehnder, Carlos, Drewe, Juergen, Gutmann, Heike, Stanga, Zeno, Vogel, Daniel, Beglinger, Christoph·2006·Digestion
DOI 10.1159/000094334
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Abstract

In previous studies with glucagon-like peptide-1 (GLP-1) we have observed that this peptide modulates fluid intake and increases renal sodium excretion in healthy volunteers and in patients with diabetes mellitus type 2. The effect of GLP-1 on thirst, water intake and on osmoregulation has, however, not been examined in detail in humans. Methods: Seventeen healthy male subjects were enrolled in two double-blind, placebo-controlled studies. In study part A, 8 volunteers participated in a protocol with an intravenous salt load of 26.7 ± 0.9 g comparing the effect of an infusion of GLP-1 (1.5 pmol/kg × min) to isotonic saline (placebo). Sodium excretion and water intake were measured. In part B, 9 volunteers were challenged with an oral salt load of 27.7 ± 0.5 g; sodium excretion and water intake were determined comparing an infusion of GLP-1 (1.5 pmol/kg × min) to isotonic saline (placebo). In part C, intestinal biopsies along the gastrointestinal tract were obtained from 14 healthy subjects. Expression of human GLP-1 receptor mRNA was measured by real-time polymerase chain reaction. Results: In study part A, an increase in renal sodium excretion was demonstrated: FeNa rose from 1.6 ± 0.3 (placebo) to 2.7 ± 0.2% (GLP-1; p = 0.0005). There was no difference in water consumption between the two treatments: 1,291 ± 69 (saline) vs. 1,228 ± 74 ml (GLP-1; p = 0.49). In part B, an oral salt challenge of 27.7 ± 0.5 g led to an increased renal excretion of sodium during GLP-1: FeNa increased from 1.6 ± 0.2% (placebo) to 2.0 ± 0.2% (GLP-1; p = 0.012). In contrast to part A, oral water intake was reduced by 36% under GLP-1 treatment: 1,848 ± 331 ml (placebo) vs. 1,181 ± 177 ml (GLP-1; p = 0.0414). Three subjects in part B did not finish treatment with GLP-1 because of diarrhea. Human GLP-1 receptor mRNA expression was highest in the proximal human small intestine compared to terminal ileum and colon (p < 0.02). Conclusions: GLP-1 acts on renal tissue reducing sodium absorption, probably via similar sodium transporters, which also may be localized in the gastrointestinal tract. This hypothesis needs to be confirmed by further studies.

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  1. 10.2337%2Fdiabetes.47.2.159 · DOI
  2. 10.1146%2Fannurev.physiol.59.1.257 · DOI

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Metadata

Authors
Gutzwiller, J.-P., Hruz, P., Huber, A. R., Hamel, C., Zehnder, C., Drewe, J., Gutmann, H., Stanga, Z., Vogel, D., & Beglinger, C.
Affiliations
  • Kantonsspital Aarau (CH)
  • Clínica Las Condes (CL)
  • University Hospital of Basel (CH)
  • University Hospital of Bern (CH)
ORCID
Venue
Digestion
Publisher
S. Karger AG
Published
2006
Volume
73
Issue
2-3
Pages
142-150
ISSN
  • 0012-2823 (ISSN-L)
  • 1421-9867
DOI
10.1159/000094334
OpenAlex
W2059555444
Cited by
127
References
23
Citations by year
2026: 10 · 2025: 6 · 2024: 5 · 2023: 7 · 2022: 5 · 2021: 4 · 2020: 2 · 2019: 8 · 2018: 2 · 2017: 7 · 2016: 12 · 2015: 9 · 2014: 10 · 2013: 13 · 2012: 3
FWCI
1.81
Type
journal article
Language
en
Open access
Licence
Locations
  • Digestion (publishedVersion)
  • PubMed (publishedVersion)
  • BORIS (University Library Bern) (submittedVersion, other-oa)
  • Open Access CRIS of the University of Bern
Funders
  • National Science Foundation
  • Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
  • Health Sciences › Medicine › Nephrology › Electrolyte and hormonal disorders
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Keywords
glucagon-like peptide-1, sodium homeostasis, water homeostasis, thirst, water intake, renal sodium excretion, osmoregulation, salt loading, gastrointestinal tract, type 2 diabetes, fluid intake regulation, GLP-1 receptor antagonists, vasopressin
MeSH terms
Adult, Analysis of Variance, Blood Glucose, Body Water, Double-Blind Method, Homeostasis, Humans, Male, Natriuresis, Sodium, Thirst, Area Under Curve, Reverse Transcriptase Polymerase Chain Reaction, Glucagon-Like Peptide 1

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