Apolipoprotein E ε4 Allele Is Associated with Vascular Dementia
Abstract
Background/Aims: The apolipoprotein E (ApoE) exon 4 polymorphism has been associated with vascular dementia (VaD) risk. Since not all studies confirm this finding, we explored this association in a case-control study. Methods: We genotyped ApoE in 144 VaD patients and 251 controls. Results: VaD patients were more likely than controls to have ApoE Ε3/Ε4 or Ε4/Ε4 genotypes: 23.6% versus 15.1%, odds ratio (OR) = 1.7, p = 0.036. This association remained significant after adjustment for age, sex, hypertension and diabetes by multiple logistic regression: OR = 1.9, p = 0.030. The association of Ε3/Ε4 or Ε4/Ε4 genotypes with VaD was strong among people with hypertension (OR = 2.9, p = 0.007) or diabetes (OR = 6.5, p = 0.011). The association was absent among people without hypertension (OR = 1.1, p = 0.79) or diabetes (OR = 1.3, p = 0.43). Conclusion: This interaction with hypertension and diabetes should be examined in other studies to confirm or refute this observation.
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The ε4 allele plays a role in vascular dementia.
“ε4 also plays a role in vascular dementia [21][22][23][24][25][26]”
From APOE and vascular disease: Sequencing and genotyping in general population cohorts (2023) · cites this paper as [23]
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References 21 · Cited by 57
- Authors
- Baum, L., Lam, L. C. W., Kwok, T., Lee, J., Chiu, H. F. K., Mok, V. C. T., Wong, A., Chen, X., Cheung, W. S., Pang, C. P., Ma, S. L., Tang, N. L. S., Wong, K. S., & Ng, H. K.
- Affiliations
- Chinese University of Hong Kong (HK)
- ORCID
- Venue
- Dementia and Geriatric Cognitive Disorders
- Publisher
- S. Karger AG
- Published
- 2006
- Volume
- 22
- Issue
- 4
- Pages
- 301-305
- ISSN
- 1420-8008 (ISSN-L)
- 1421-9824
- OpenAlex
- W2036545376
- Cited by
- 57
- References
- 21
- Citations by year
- 2024: 2 · 2023: 1 · 2022: 1 · 2020: 3 · 2019: 1 · 2018: 2 · 2017: 1 · 2016: 3 · 2015: 4 · 2014: 5 · 2013: 3 · 2012: 5
- FWCI
- 2.77
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Dementia and Geriatric Cognitive Disorders (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Chinese University of Hong Kong
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- apolipoprotein E, APOE ε4, vascular dementia, genetic susceptibility, hypertension, diabetes mellitus, APOE genotype, case-control association
- MeSH terms
- Aged, Alleles, Cerebrovascular Disorders, DNA, Exons, Female, Humans, Male, Middle Aged, Dementia, Vascular, Odds Ratio, Case-Control Studies, Risk Assessment, Reverse Transcriptase Polymerase Chain Reaction, Stroke, Apolipoprotein E4
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