The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
KiSS-1 and Reproduction: Focus on Its Role in the Metabolic Regulation of Fertility
Abstract
Unraveling of the master role of kisspeptins, the products of the KiSS-1 gene, and their receptor, GPR54, in the control of reproduction has been a major breakthrough in contemporary neuroendocrinology. Indeed, since the disclosure of their reproductive dimension in late 2003, an ever-growing number of genetic, molecular, physiologic and pharmacological studies have defined the crucial role of KiSS-1 neurons as central processors for the dynamic regulation of the gonadotropic axis and its full activation at puberty. Yet, the potential role of the hypothalamic KiSS-1 system as an intermediary factor for the well-known interplay between energy status and reproduction initially received little attention. Recent data, however, strongly suggest a prominent role of KiSS-1 in the metabolic control of fertility, as expression of KiSS-1 gene at the hypothalamus is down-regulated in conditions of negative energy balance and kisspeptin administration is capable of overcoming the hypogonadotropic state observed in undernutrition and disturbed metabolic conditions. Leptin, the adipocyte hormone signaling the size of body energy stores, is likely to play a pivotal role in the metabolic control of the KiSS-1 system, since kisspeptin neurons express leptin receptors and leptin is able to normalize defective KiSS-1 gene expression in models of impaired gonadotropin secretion linked to hypoleptinemia, such as the ob/ob mouse and streptozotocin-induced diabetic rat. In sum, these data provide strong evidence for a central role of kisspeptins and GPR54 as molecular conduits for the metabolic regulation of reproductive function – a phenomenon with potential physiopathologic and therapeutic implications.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Evidence from studies of animal models points to a role for kisspeptin 1 in the reproductive effects of leptin.”
From The genetic and molecular basis of idiopathic hypogonadotropic hypogonadism (2009) · cites this paper as [62]
Citations
Cites
The GPR54 Gene as a Regulator of Puberty
Seminara, S. B., Messager, S., Chatzidaki, E. E., Thresher, R. R., Acierno, J. S., Shagoury, J. K., Bo-Abbas, Y., Kuohung, W., Schwinof, K. M., Hendrick, A. G., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa035322 · Cited by 2,557
Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54
de Roux, N., Genin, E., Carel, J.-C., Matsuda, F., Chaussain, J.-L., & Milgrom, E. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1834399100 · Cited by 2,431 · cited 1×
“In late 2003, our understanding of the factors involved in the central control of reproduction was revolutionized by the finding, independently reported by de Roux et al. [”
ResultKotani, M., Detheux, M., Vandenbogaerde, A., Communi, D., Vanderwinden, J.-M., Le Poul, E., Brézillon, S., Tyldesley, R., Suarez-Huerta, N., Vandeput, F., et al. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104847200 · Cited by 1,546
Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor
Ohtaki, T., Shintani, Y., Honda, S., Matsumoto, H., Hori, A., Kanehashi, K., Terao, Y., Kumano, S., Takatsu, Y., Masuda, Y., et al. (2001) · Nature · doi:10.1038/35079135 · Cited by 1,447
Messager, S., Chatzidaki, E. E., Ma, D., Hendrick, A. G., Zahn, D., Dixon, J., Thresher, R. R., Malinge, I., Lomet, D., Carlton, M. B. L., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409330102 · Cited by 1,242
A role for kisspeptins in the regulation of gonadotropin secretion in the mouse
Gottsch, M. L., Cunningham, M. J., Smith, J. T., Popa, S. M., Acohido, B. V., Crowley, W. F., Seminara, S., Clifton, D. K., & Steiner, R. A. (2004) · Endocrinology · doi:10.1210/en.2004-0431 · Cited by 1,161
Regulation of Kiss1 gene expression in the brain of the female mouse
Smith, J. T., Cunningham, M. J., Rissman, E. F., Clifton, D. K., & Steiner, R. A. (2005) · Endocrinology · doi:10.1210/en.2005-0488 · Cited by 1,102
KiSS-1, a Novel Human Malignant Melanoma Metastasis-Suppressor Gene
Lee, J.-H., Miele, M. E., Hicks, D. J., Phillips, K. K., Trent, J. M., Weissman, B. E., & Welch, D. R. (1996) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/88.23.1731 · Cited by 1,072
Han, S.-K., Gottsch, M. L., Lee, K. J., Popa, S. M., Smith, J. T., Jakawich, S. K., Clifton, D. K., Steiner, R. A., & Herbison, A. E. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.3328-05.2005 · Cited by 1,036
Irwig, M. S., Fraley, G. S., Smith, J. T., Acohido, B. V., Popa, S. M., Cunningham, M. J., Gottsch, M. L., Clifton, D. K., & Steiner, R. A. (2004) · Neuroendocrinology · doi:10.1159/000083140 · Cited by 930
Cited by
Sorted by citations
Items 101–132 of 132
Srivastava, V. K., Hiney, J. K., Stevener, K., & Dees, W. L. (2015) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.12905 · Cited by 11
Xu, Y. J., Han, C. Y., Park, M. J., & Gye, M. C. (2022) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-022-00944-z · Cited by 8
β‐Sheet aggregation of kisspeptin‐10 is stimulated by heparin but inhibited by amphiphiles
Nielsen, S. B., Franzmann, M., Basaiawmoit, R. V., Wimmer, R., Mikkelsen, J. D., & Otzen, D. E. (2010) · Biopolymers · doi:10.1002/bip.21434 · Cited by 8
Weber, G. M. (2009) · doi:10.1002/9780813807379.ch13 · Cited by 8
Is there a hypothalamic basis for anorexia nervosa?
Tolle, V., Ramoz, N., & Epelbaum, J. (2021) · Handbook of clinical neurology · doi:10.1016/b978-0-12-820683-6.00030-0 · Cited by 7
Millar, R. P., Newton, C. L., & Roseweir, A. K. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-375097-6.10002-2 · Cited by 6
Husna, M. S. S. A., Flatscher‐Bader, T., Lehnert, S. A., Reverter, A., Chan, E., Phillips, N. J., McGowan, M., & D’Occhio, M. J. (2012) · Simulating the effects of changing planting date towards rice production in MADA area Malaysia · Cited by 6
Reproductive Regulation of PrRPs in Teleost: The Link Between Feeding and Reproduction
Xia, C., Qin, X., Zhou, L., Shi, X., Cai, T., Xie, Y., Li, W., Du, R., Ouyang, Y., Yin, Z., et al. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.762826 · Cited by 5
Febriana, A., Sutopo, S., Kurnianto, E., & Widiyanto, W. (2021) · Journal of the Indonesian Tropical Animal Agriculture · doi:10.14710/jitaa.46.4.282-294 · Cited by 5
Chapter 2 Endocrine Targets of the Hypothalamus and Pituitary
Kah, O. (2009) · Fish physiology · doi:10.1016/s1546-5098(09)28002-2 · Cited by 15
New Insights in Bovine Follicular Cysts
Carbonari, A., Martino, N. A., Burgio, M., Cicirelli, V., Frattina, L., Dell’Aquila, M. E., & Rizzo, A. (2025) · Reproduction in Domestic Animals · doi:10.1111/rda.70048 · Cited by 4
Mecanismos reguladores de la pubertad en la cabra: actualización de algunos conceptos
Meza-Herrera, C. A. (2008) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) · Cited by 4
Hatef, A., Rajeswari, J. J., & Unniappan, S. (2022) · Aquaculture and Fisheries · doi:10.1016/j.aaf.2022.02.003 · Cited by 3
Tkanka tłuszczowa jako narząd wydzielania wewnętrznego
Mazur, A., Matusik, P., & Małecka‐Tendera, E. (2010) · Pediatria Polska · doi:10.1016/s0031-3939(10)70033-0 · Cited by 3
Effects of prenatal stress on reproductive function of male offspring through the KISS1 system
Gong, J., Lv, Y., Meng, Y., Zhang, W., Jiang, X., & Xiao, M. (2024) · Endocrine Connections · doi:10.1530/ec-24-0027 · Cited by 1
A NARRATIVE REVIEW OF ADDRESSING FEMALE REPRODUCTIVE DISORDERS: THE POTENTIAL ROLE OF MELATONIN.
Pervez, A. (2023) · Student s Journal of Health Research Africa · doi:10.51168/sjhrafrica.v4i12.897 · Cited by 1
The Role of KNDy Neurons in Estrogen Modulation of LH Release, Body Weight, and Thermoregulation
Smith, M. A. (2012) · UA Campus Repository (The University of Arizona) · Cited by 1
De Novo Assembly and Analysis of the Testes Transcriptome from the Menhaden, Bervoortia tyrannus
Zadlock, F. J., Rana, S., Alvi, Z. A., Zhang, Z., Murphy, W., & Bentivegna, C. S. (2017) · Fisheries and Aquaculture Journal · doi:10.4172/2150-3508.1000186
Geraudie, P., Gerbron, M., Lockyer, A. E., Jobling, S., & Minier, C. (2018) · Environmental Science and Pollution Research · doi:10.1007/s11356-018-3299-x
Amato, L. G. L. (2018) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.5.2018.tde-22102018-142108
Luteinizing Hormone effect on the GDF-9 and BMPR-1a Expression of Bovine Granulosa Cells culture
Rahayu, S., Prasetyawan, S., Souhaly, J. W., & Ciptadi, G. (2019) · IOP Conference Series Materials Science and Engineering · doi:10.1088/1757-899x/546/6/062021
Xu, Y., Han, C. Y., Park, M. J., & Gye, M. C. (2021) · Research Square · doi:10.21203/rs.3.rs-829382/v1
(2007) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0b013e3282f315ef
Nano-Encapsulated Kisspeptin Peptides Enhanced the Gonadal Maturity in Labeo CatlaPreprint
Kar, S., Bhat, I. A., Mushtaq, M. W., Pathan, M. A., Nayak, S., Reang, D., Rather, M. A., Kumar, D., & Sharma, R. (2025) · SSRN Electronic Journal · doi:10.2139/ssrn.5352347
Xu, Y., Han, C. Y., Park, M. J., & Gye, M. C. (2022) · Figshare · doi:10.6084/m9.figshare.19641934
Xu, Y., Han, C. Y., Park, M. J., & Gye, M. C. (2022) · Figshare · doi:10.6084/m9.figshare.19641937
Xu, Y., Han, C. Y., Park, M. J., & Gye, M. C. (2022) · Figshare · doi:10.6084/m9.figshare.19641940
Metadata
- Authors
- Tena-Sempere, M.
- Venue
- Neuroendocrinology
- Publisher
- S. Karger AG
- Published
- 2006
- Volume
- 83
- Issue
- 5-6
- Pages
- 275-281
- ISSN
- 0028-3835 (ISSN-L)
- 1423-0194
- OpenAlex
- W2113860075
- Cited by
- 132
- References
- 35
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 3 · 2022: 5 · 2021: 9 · 2020: 3 · 2019: 4 · 2018: 6 · 2017: 5 · 2016: 1 · 2015: 1 · 2014: 4 · 2013: 13 · 2012: 10
- FWCI
- 2.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- kisspeptin, KISS1, GPR54, kisspeptin neurons, hypothalamus, energy balance, leptin, leptin receptor, hypogonadotropic hypogonadism, malnutrition, gonadotropin secretion, puberty, ob/ob mice, streptozotocin-induced diabetes, fertility control
- MeSH terms
- Receptors, Kisspeptin-1, Animals, Energy Metabolism, Fertility, Humans, Hypothalamus, Neurosecretory Systems, Reproduction, Sexual Maturation, Signal Transduction, Leptin, Tumor Suppressor Proteins, Receptors, G-Protein-Coupled, Kisspeptins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
