The DOI matches its Crossref record.
Small-Vessel Vascular Disease in Human Immunodeficiency Virus Infection: The Hawaii Aging with HIV Cohort Study
Abstract
Background This study is designed to determine the relationship between age and occurrence of cerebral manifestations of small-vessel ischemic vascular disease in human immunodeficiency virus (HIV)-seropositive individuals. Methods Periventricular leukoaraiosis severity and white matter lesion volume were determined by magnetic resonance imaging of the brain of 57 HIV-seropositive individuals. Results Cerebral small-vessel ischemic vascular disease manifestations correlated with age and systolic blood pressure, but not with HIV infection-related parameters. Conclusions These findings suggest that, in the era of highly active antiretroviral therapy, leukoaraiosis severity and white matter lesion volume may be more indicative of small-vessel ischemic vascular disease than HIV-related CNS pathology, and support the need for aggressive treatment of vascular risk factors in HIV-seropositive individuals.
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Small-vessel cerebral ischemic disease is prominent in HIV-1-associated dementia.
“MRI studies reveal that small-vessel cerebral ischemic disease is also prominent in HAD (401).”
From Blood-Brain Barrier: From Physiology to Disease and Back (2019) · cites this paper as [401]
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Blood-Brain Barrier: From Physiology to Disease and Back
Sweeney, M. D., Zhao, Z., Montagne, A., Nelson, A. R., & Zlokovic, B. V. (2019) · Physiological Reviews · doi:10.1152/physrev.00050.2017 · Cited by 2,312
Metadata
- Authors
- McMurtray, A., Nakamoto, B., Shikuma, C., & Valcour, V.
- Affiliations
- University of Hawaiʻi at Mānoa (US)
- Venue
- Cerebrovascular Diseases
- Publisher
- S. Karger AG
- Published
- 2007
- Volume
- 24
- Issue
- 2-3
- Pages
- 236-241
- ISSN
- 1015-9770 (ISSN-L)
- 1421-9786
- OpenAlex
- W2064551122
- Cited by
- 46
- References
- 0
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 3 · 2021: 1 · 2020: 2 · 2019: 2 · 2018: 6 · 2017: 7 · 2016: 3 · 2014: 7 · 2013: 1 · 2012: 2
- FWCI
- 1.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cerebrovascular Diseases (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Academy of Neurology
- National Institutes of Health (5p20rr011091-15)
- National Institute of Allergy and Infectious Diseases (G12 RR/AI03061)
- National Institute of Neurological Disorders and Stroke (U54NS043049)
- National Center for Research Resources (P20-RR11091, R25RR019321)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Cerebrovascular and genetic disorders
- Health Sciences › Medicine › Infectious Diseases › HIV-related health complications and treatments
- Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
- Keywords
- HIV infection, white matter lesions, aging, systolic blood pressure, cerebrovascular risk factors, highly active antiretroviral therapy, HIV-associated neurocognitive disorders
- MeSH terms
- Adult, Age Factors, Aging, Blood Pressure, Cerebral Arteries, Brain Ischemia, Female, Hawaii, HIV Seropositivity, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Population Surveillance, Risk Factors, Severity of Illness Index, Cohort Studies, AIDS Dementia Complex, Linear Models, Risk Assessment, Leukoaraiosis
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