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Mitochondrial Ca 2+ Transport and the Role of Intramitochondrial Ca 2+ in the Regulation of Energy Metabolism
Abstract
The mitochondrial inner membrane of all mammalian tissues, including brain tissues, has specific active transport systems for the uptake and egress of Ca2+. The primary role of this transport system is to relay changes in cytosolic [Ca2+], which stimulates energy-requiring processes in the cytosol (e.g. secretion), into the mitochondrial matrix where it stimulates several key steps in energy production. Thus using the same second-messenger molecule, the latter events allow energetic homeostasis to be maintained under conditions of cell stimulation. This appears to be brought about by a co-ordinated enhancement of steps throughout the pathways of oxidative phosphorylation, including substrate supply to the respiratory chain by dehydrogenase activation, activation of the respiratory chain itself by a mechanism which appears to involve changes in the matrix volume, and also possibly activation of the ATP synthetase where the release of a specific inhibitory subunit has been proposed.
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“Inhibiting MPT pore opening may also prevent the loss of enzyme scavengers of ROS within the matrix that normally neutralizes ROS in the matrix (220).”
From Mitochondrial reactive oxygen species production in excitable cells: Modulators of mitochondrial and cell function (2009) · cites this paper as [220]
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BackgroundKumar, A., Kumar, P., Dixit, S., Kumar, N., & Alam, B. (2025) · EPJ Web of Conferences · doi:10.1051/epjconf/202534101031
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Metadata
- Authors
- McCormack, J. G., & Denton, R. M.
- Affiliations
- Heriot-Watt University (GB)
- Venue
- Developmental Neuroscience
- Publisher
- S. Karger AG
- Published
- 1994-08-18
- Volume
- 15
- Issue
- 3-5
- Pages
- 165-173
- ISSN
- 0378-5866 (ISSN-L)
- 1421-9859
- OpenAlex
- W1986720672
- Cited by
- 150
- References
- 0
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 5 · 2023: 5 · 2022: 6 · 2021: 5 · 2020: 8 · 2019: 4 · 2018: 3 · 2017: 9 · 2016: 6 · 2014: 7 · 2013: 3 · 2012: 5
- FWCI
- 1.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Developmental Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › ATP Synthase and ATPases Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- mitochondrial calcium transport, mitochondrial calcium, energy metabolism, inner mitochondrial membrane, oxidative phosphorylation, ATP synthase, intracellular calcium, brain mitochondria
- MeSH terms
- Animals, Biological Transport, Calcium, Energy Metabolism, Humans, Mitochondria
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