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Animal Models for Predicting Clinical Efficacy of Anxiolytic Drugs: Social Behaviour
Abstract
The behavioural, physiological and pharmacological validation of one animal test of anxiety, the social interaction test, is described in detail. The effects of anxiolytic and anxiogenic drugs, and manipulations of catecholaminergic and serotonergic pathways are considered. The test is able to distinguish anxiolytic from sedative effects and is not sensitive to the actions of antidepressants or neuroleptics.
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“In the social interaction task, social contacts between unfamiliar individuals in a brightly illuminated arena are quantified; anxiolytics have been found to increase social interaction in this task51.”
From Resolving the neural circuits of anxiety (2015) · cites this paper as [51]
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“Finally, tac1 −/− and tac1 +/+ mice were tested in the social activity paradigm ( File 1985 ).”
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“indoleamines, of which catecholamines are mainly composed of dopamine, norepinephrine, and epinephrine, and indoleamines are especially 5-hydroxytryptamine (5-HT; File, 1985; Bernardy and Friedman, 2015).”
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Self-citationUse of Mice with Targeted Genetic Inactivation in the Serotonergic System for the Study of Anxiety
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Metadata
- Authors
- File, S. E.
- Affiliations
- University of London (GB)
- Corresponding author
- File, Sandra E.
- Venue
- Neuropsychobiology
- Publisher
- S. Karger AG
- Published
- 2008-02-19
- Volume
- 13
- Issue
- 1-2
- Pages
- 55-62
- ISSN
- 0302-282X (ISSN-L)
- 1423-0224
- OpenAlex
- W1967111731
- Cited by
- 141
- References
- 0
- Citations by year
- 2024: 1 · 2023: 1 · 2022: 1 · 2021: 3 · 2020: 1 · 2017: 2 · 2016: 2 · 2015: 4
- FWCI
- 1.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuropsychobiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- social interaction test, anxiety, anxiolytics, anxiogenic drugs, sedative effects, animal models of anxiety, drug efficacy prediction, catecholaminergic pathways, serotonergic pathways, antidepressants, antipsychotic drugs
- MeSH terms
- Animals, Anxiety, Benzodiazepines, Brain, Catecholamines, Drug Evaluation, Preclinical, Humans, Synaptic Transmission, Receptors, GABA-A, Serotonin, Social Behavior, Anti-Anxiety Agents, Rats
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