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Postweaning Development of Negative Feedback in the Pituitary-Adrenal System of the Rat
Abstract
In response to ether or electric shock, plasma corticosterone concentrations in weanling and adult rats rose to equivalent levels by 15 min, but then diverged, with the weanlings showing a later peak and a slower return to resting levels. An interpretation of this effect, in terms of an immature feedback mechanism in weanling rats, was supported by an experiment in which pretreatment with peripherally injected dexamethasone completely blocked a plasma corticosterone increase, in response to an ether and blood sampling stress in adults, but only partially reduced this response in weanlings. The failure of basal hypothalamic implants of corticoids to differentiate between ages in their ability to inhibit this stress response supported the suggestion of extra-hypothalamic inhibitory systems as the loci of the deficit in weanlings.
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Citations
Cited by
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Spear, L. P. (2000) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(00)00014-2 · Cited by 5,433
The dynamic effects of nicotine on the developing brain
Dwyer, J. B., McQuown, S. C., & Leslie, F. M. (2009) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2009.02.003 · Cited by 559
Sheng, J. A., Bales, N. J., Myers, S. A., Bautista, A. I., Roueinfar, M., Hale, T. M., & Handa, R. J. (2021) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2020.601939 · Cited by 418
Levine, S. (2001) · Physiology & Behavior · doi:10.1016/s0031-9384(01)00496-6 · Cited by 428
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Metadata
- Authors
- Goldman, L., Winget, C., Hollingshead, G. W., & Levine, S.
- Venue
- Neuroendocrinology
- Publisher
- S. Karger AG
- Published
- 1973
- Volume
- 12
- Issue
- 3
- Pages
- 199-211
- ISSN
- 0028-3835 (ISSN-L)
- 1423-0194
- OpenAlex
- W1976934495
- Cited by
- 202
- References
- 0
- FWCI
- 4.69
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- karger.com/pages/terms-and-conditions (vor)
- karger.com/pages/terms-and-conditions (tdm)
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- Goldman, L., Winget, C., Hollingshead, G. W., & Levine, S. (1973). Postweaning Development of Negative Feedback in the Pituitary-Adrenal System of the Rat. Neuroendocrinology. https://doi.org/10.1159/000122169
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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