The DOI matches its Crossref record.
Effects of Intravenous Corticotropin-Releasing Hormone upon Sleep-Related Growth Hormone Surge and Sleep EEG in Man
Abstract
Corticotropin-releasing hormone (CRH) plays a key role in coordinating neuroendocrine, metabolic and behavioral responses in stress and affective disorders. To further investigate the effects of enhanced pituitary-adrenocortical activity upon sleep-related phenomena we administered four intravenous injections of 50 µg human (h)-CRH or saline to 11 normal males at 10 p.m., 11 p.m., 12 p.m. and 1 a.m. and measured plasma levels of cortisol and growth hormone (GH) as well as sleep EEG recordings throughout the night. Treatment with h-CRH resulted in a significant increase of mean (± SEM) cortisol secretion between 11 p.m. and 3 a.m. (h-CRH: 100.6 + 9.5 ng/ml; saline: 39.0 ± 1.5 ng/ml; p < 0.01). This initial cortisol increase after repeated h-CRH stimulations was followed by a period of attenuated plasma cortisol between 3 and 7 a.m. (h-CRH: 70.3 + 7.0 ng/ml; saline: 115.5 ± 8.0 ng/ml; p < 0.01). Cortisol surges after h-CRH were associated with a significant blunting of sleep-related GH release expressed as areas under concentration curves (h-CRH: 1.245 ± 0.32 ng/ml/min · 103; saline: 2.462 + 0.92 ng/ml/min· 103, p < O.01). In addition to these hormonal effects, h-CRH induced a decrease of REM and slow wave sleep (stages III and IV) while the amount of more shallow sleep (stages I and II)increased. These effects upon sleep structure were more pronounced during the second part of the night. We conclude that h-CRH induces effects in healthy humans (GH blunting and SWS reduction) which resemble those seen among hypercortisolemic depressives and surmise that CRH plays a role to mediate endocrine as well as behavioral phenomena in the affective disorders.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“there is in turn strong evidence that elevated CRH tone increases sleep EEG frequency, thereby decreasing SWS, and increasing light sleep and wakefulness [94].”
From Impact of Sleep and Its Disturbances on Hypothalamo-Pituitary-Adrenal Axis Activity (2010) · cites this paper as [94]
Citations
Cited by
Sorted by citations
Items 101–200 of 256
Hair Cortisol Concentration as a Biomarker of Sleep Quality and Related Disorders
Mlili, N. E., Ahabrach, H., & Cauli, O. (2021) · Life · doi:10.3390/life11020081 · Cited by 50
Tayama, J., Sagami, Y., Shimada, Y., Hongo, M., & Fukudo, S. (2007) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2007.00903.x · Cited by 48
von Bardeleben, U., & Holsboer, F. (1988) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/0278-5846(88)90079-6 · Cited by 45
Self-citationAntonijevic, I. A., Murck, H., Frieboes, R.-M., Barthelmes, J., & Steiger, A. (2000) · PubMed · Cited by 50
Self-citationGuldner, J., Schier, T., Frieß, E., Colla, M., Holsboer, F., & Steiger, A. (1997) · Neurobiology of Aging · doi:10.1016/s0197-4580(97)00106-1 · Cited by 49
Self-citationHypnotics and sleep physiology: A consensus repot
Borbély, A. A., Åkerstedt, T., Benoit, O., Holsboer, F., & Oswald, I. (1991) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/bf02193749 · Cited by 46
“The administration of various hormones (e.g. corticotropin-releasing hormone; Holsboer et al. 1988) may modify sleep, and the secretion of hormones may in turn undergo sleep-related changes (various pituitary hormones: Steiger et al. 1987a; Follenius et al. 1988; renin: Brandenberger et al. 1988).”
BackgroundSelf-citationSleep and Hormonal Changes in Aging
Copinschi, G., & Caufriez, A. (2013) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2013.02.009 · Cited by 43
Voderholzer, U., Laakmann, G., Wittmann, R., Daffner, C., Hinz, A., Haag, C., & Baghai, T. C. (1993) · Psychiatry Research · doi:10.1016/0165-1781(93)90080-z · Cited by 44
All-night electroencephalographic sleep and cranial computed tomography in depression
Lauer, C. J., Wiegand, M. H., & Krieg, J.-C. (1992) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/bf02191547 · Cited by 43
“On the other hand, the pulsed administration of CRH causes a decrease in SWS (Holsboer et al., 1988).”
BackgroundModelling and exploring human sleep with event history analysis
Yassouridis, A., Steiger, A., Klinger, A., & Fahrmeir, L. (1999) · Journal of Sleep Research · doi:10.1046/j.1365-2869.1999.00133.x · Cited by 43
“Under acuteThis finding is similar to a previous observation by Born et al. administration of CRH, REM sleep is diminished in normal(1991), who reported an association between decreasing cortisol subjects (Holsboer et al. 1988).”
ResultSelf-citationKluge, M., SCHÜSSLER, P., Zuber, V., Yassouridis, A., & Steiger, A. (2007) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2006.12.015 · Cited by 42
Self-citationMaes, M. H. J., Meltzer, H. Y., Suy, E., Minner, B., Calabrese, J. R., & Cosyns, P. R. (1993) · Journal of Affective Disorders · doi:10.1016/0165-0327(93)90007-7 · Cited by 43
Hubain, P., Staner, L., Dramaix, M., Kerkhofs, M., Papadimitriou, G., Mendlewicz, J., & Linkowski, P. (1998) · Biological Psychiatry · doi:10.1016/s0006-3223(97)80434-9 · Cited by 40
SCHÜSSLER, P., Yassouridis, A., Uhr, M., Kluge, M., Weikel, J., Holsboer, F., & Steiger, A. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00641.2005 · Cited by 41
“Similarly, SWS, REMS, and GH decrease after CRH administration to young normal male subjects (17).”
BackgroundResultInfluentialSelf-citationZiegenbein, M., Held, K., Kuenzel, H., Murck, H., Antonijevic, I. A., & Steiger, A. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300298 · Cited by 40
“Sleep-EEG recordings were scored manually by a rater who was unaware of the treatment and experienced in the use of standard guidelines, as previously described (Rechtschaffen and Kales, 1968; Holsboer et al, 1988).”
MethodSelf-citationGronfier, C., Chapotot, F., Weibel, L., Jouny, C. C., Piquard, F., & BRANDENBERGER, G. (1998) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1998.275.1.e94 · Cited by 38
The Relationship Between Tobacco Smoking, Cortisol Secretion, and Sleep Continuity
Cohen, A., Colodner, R., Masalha, R., & Haimov, I. (2019) · Substance Use & Misuse · doi:10.1080/10826084.2019.1608250 · Cited by 41
Galanin has REM-sleep deprivation-like effects on the sleep eeg in healthy young men
Murck, H., Antonijevic, I. A., Frieboes, R.-M., Maier, P., Schier, T., & Steiger, A. (1999) · Journal of Psychiatric Research · doi:10.1016/s0022-3956(98)00059-4 · Cited by 36
Self-citationSteiger, A., Guldner, J., Knisatschek, H., Rothe, B., Lauer, C. J., & Holsboer, F. (1991) · Peptides · doi:10.1016/0196-9781(91)90051-p · Cited by 36
Self-citationThe Role of Peptides in Treatment of Psychiatric Disorders
Holsboer, F. (2003) · Journal of neural transmission. Supplementum · doi:10.1007/978-3-7091-6020-6_2 · Cited by 35
Self-citationFrieboes, R.-M., Antonijevic, I. A., Held, K., Murck, H., Pollmächer, T., Uhr, M., & Steiger, A. (2003) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(03)00152-5 · Cited by 36
Self-citationArvat, E., Maccagno, B., Ramunni, J., Maccario, M., Giordano, R., Broglio, F., Camanni, F., & Ghigo, E. (2000) · European Journal of Endocrinology · doi:10.1530/eje.0.1430099 · Cited by 35
Kotronoulas, G., Stamatakis, A., & Stylianopoulou, F. (2009) · HORMONES · doi:10.14310/horm.2002.1239 · Cited by 33
“The hypothesis that CRH promotes REMS is also supported.(50) However, it is claimed that the influence of endogenous CRH on REMS is uncertain as the amount of REMS decreases after CRH.”
BackgroundInfluentialOptimal glucocorticoid replacement in adrenal insufficiency
Øksnes, M., Ross, R. J. M., & Løvås, K. (2014) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2014.09.009 · Cited by 31
Steiger, A., Rupprecht, R., Spengler, D., Guldner, J., Hemmeter, U., Rothe, B., Damm, K., & Holsboer, F. (1993) · Journal of Psychiatric Research · doi:10.1016/0022-3956(93)90038-4 · Cited by 32
Self-citationAustin, M. C., Rice, P. M., Mann, J. J., & Arango, V. (1995) · Neuroscience · doi:10.1016/0306-4522(94)00420-a · Cited by 31
Direct effects of corticotrophin-releasing hormone on stimulated growth hormone secretion
Raza, J., Massoud, A. F., Hindmarsh, P. C., Robinson, I. C. A. F., & Brook, C. G. D. (1998) · Clinical Endocrinology · doi:10.1046/j.1365-2265.1998.3821204.x · Cited by 31
“These results are in agreement with earlier reports (Holsboer et al., 1988; Barbarinoet al., 1990; Ghizzoniet al., 1996), although others have failed to document this effect (Hartog et al.”
ResultKeck, M. E., HOLSBOER, F., & Müller, M. B. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1296.055 · Cited by 28
Self-citationThe Molecular Basis of Insomnia: Implication for Therapeutic Approaches
Wang, Z., & Liu, J. (2016) · Drug Development Research · doi:10.1002/ddr.21338 · Cited by 30
“In humans, CRH also decreased SWS and increase wake [Holsboer et al., 1988; Vgontzas et al., 2001b].”
BackgroundFrieboes, Murck, Antonijevic, et al. (1999) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.1999.00364.x · Cited by 28
Self-citationEffects of hCRH on sleep and body temperature rhythms
Tsuchiyama, Y., Uchimura, N., Sakamoto, T., Maeda, H., & Kotorii, T. (1995) · Psychiatry and Clinical Neurosciences · doi:10.1111/j.1440-1819.1995.tb01906.x · Cited by 28
Buckley, T. M., Duggal, V., & Schatzberg, A. F. (2008) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.27186 · Cited by 27
Wichniak, A., Brünner, H., Ising, M., Gil, F. P., Holsboer, F., & Frieß, E. (2004) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2003.11.004 · Cited by 27
Self-citationCauter, E. V. (2005) · Elsevier eBooks · doi:10.1016/b0-72-160797-7/50029-x · Cited by 27
Growth hormone secretion during sleep in male depressed patients
Sakkas, P. N., Soldatos, C. R., Bergiannaki, J. D., Paparrigopoulos, T. J., & Stefanis, C. N. (1998) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(98)00018-9 · Cited by 26
Steiger, A., Guldner, J., Colla-Müller, M., Frieß, E., Sonntag, A., & Schier, T. (1994) · Journal of Psychiatric Research · doi:10.1016/0022-3956(94)90008-6 · Cited by 26
Self-citationStraub, R. H., Detert, J., Dziurla, R., Fietze, I., Loeschmann, P.-A., Burmester, G. R., & Buttgereit, F. (2017) · NeuroImmunoModulation · doi:10.1159/000475714 · Cited by 25
Taishi, P., de, A. R., Alt, J. A., Gardi, J., Obál, F., & Krueger, J. M. (2004) · Journal of Neuroendocrinology · doi:10.1111/j.0953-8194.2004.01138.x · Cited by 25
Sleep electroencephalography as a biomarker in depression
Steiger, A., Pawlowski, M. A., & Kimura, M. (2015) · ChronoPhysiology and Therapy · doi:10.2147/cpt.s41760 · Cited by 27
“In particular, in young male healthy subjects, decreases in SWS and growth hormone occurred, and in young healthy women, decrease inN3, increased wakefulness, and more REM sleep during the first third of the night were found.(114,115) Subchronic treatment with the synthetic glucocorticoid receptor agonist methylpredni…”
Self-citationHemmeter, U., Rothe, B., Guldner, J., Holsboer, F., & Steiger, A. (1998) · Neuropsychobiology · doi:10.1159/000026513 · Cited by 25
“, 1996], whereas others, such as corticotropinreleasing hormone (CRH) and the ACTH/MSH(4–9) analogue ebiratide, are capable of disturbing sleep and increasing wakefulness [Ehlers et al., 1986; Holsboer et al., 1988; Steiger et al., 1991].”
BackgroundMethodInfluentialSelf-citationJarrett, D. B., Kupfer, D. J., Miewald, J. M., et al. (1994) · Journal of Psychiatric Research · doi:10.1016/0022-3956(94)90007-8 · Cited by 25
Domagalska, J., Rusin, M., Razzaghi, M., & Nowak, P. G. (2021) · Frontiers in Psychology · doi:10.3389/fpsyg.2021.626945 · Cited by 30
“It is indicated that over 40% of teachers resign from work during the first 5 years of work because of experiencing depressive thoughts related to the sense of responsibility for the education of their students (Hussey et al., 2012).”
BackgroundSleep Endocrine Effects of the 11-β-Hydroxysteroiddehydrogenase Inhibitor Metyrapone
Jahn, H., Kiefer, F., Schick, M., Yassouridis, A., Steiger, A., Kellner, M. B., & Wiedemann, K. (2003) · SLEEP · doi:10.1093/sleep/26.7.823 · Cited by 24
Self-citationModulation of Endocrine Function by Sleep-Wake Homeostasis and Circadian Rhythmicity
Pannain, S., & Cauter, E. V. (2007) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2007.03.001 · Cited by 22
Staner, L., Duval, F., Haba, J., Mokrani, M. C., & Macher, J. P. (2002) · Journal of Psychiatric Research · doi:10.1016/s0022-3956(02)00068-7 · Cited by 23
Weight gain and all-night EEG-sleep in anorexia nervosa
Lauer, C. J., & Krieg, J.-C. (1992) · Biological Psychiatry · doi:10.1016/0006-3223(92)90250-4 · Cited by 23
Neuroendocrine–Immune Regulatory Network of Eucommia ulmoides Oliver
Zhao, Y., Tan, D., Peng, B., Yang, L. W., Zhang, S.-Y., Shi, R.-P., Chong, C., Zhong, Z., Wang, S., Liang, Q., et al. (2022) · Molecules · doi:10.3390/molecules27123697 · Cited by 24
Hyporesponsiveness of the Pituitary to CRH during Slow Wave Sleep Is Not Mimicked by Systemic GHRH
Antonijevic, I. A., Murck, H., Frieboes, R.-M., Holsboer, F., & Steiger, A. (1999) · Neuroendocrinology · doi:10.1159/000054406 · Cited by 22
Self-citationPhysiological Correlates of Insomnia
Roehrs, T., Gumenyuk, V., Drake, C. L., & Roth, T. G. (2014) · Current topics in behavioral neurosciences · doi:10.1007/7854_2014_324 · Cited by 21
Relation between growth hormone and Cortisol spontaneous secretion in children
Martinelli, C. E., & Moreira, A. C. (1994) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1994.tb03792.x · Cited by 21
“sleep after C R H administration may also be the consequence of a change in sleep pattern (Holsboer et al., 1988).”
BackgroundSleep and circadian rhythms in normal aging
Carrier, J., & Bliwise, D. L. (2003) · Springer eBooks · doi:10.1007/978-1-4615-0217-3_24 · Cited by 24
Lauer, C. J., Schreiber, W., Berger, T., et al. (1989) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/bf00381467 · Cited by 20
Self-citationVeldhuis, J. D., Iranmanesh, A., Mielke, K. L., Miles, J. M., Carpenter, P. C., & Bowers, C. Y. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-2718 · Cited by 19
Seifritz, E., Müller, M. J., Trachsel, L., Lauer, C. J., Hemmeter, U., Hatzinger, M., Moore, P., & Holsboer‐Trachsler, E. (1996) · Biological Psychiatry · doi:10.1016/0006-3223(95)00319-3 · Cited by 19
Schlegel, S., von Bardeleben, U., Wiedemann, K., Frommberger, U., & Holsboer, F. (1989) · Psychoneuroendocrinology · doi:10.1016/0306-4530(89)90019-x · Cited by 19
Self-citationWang, T., Ma, Y., Zhang, C., Liu, X., Sun, Y., Wang, H., Wang, H., Zhong, Y.-H., Su, Y., Li, J., et al. (2022) · Neuroscience Bulletin · doi:10.1007/s12264-022-00903-z · Cited by 18
“ICV or intraventricular administration of CRH has been shown to increase REM sleep and wakefulness and to decrease the amount of slow-wave sleep (also known as NREM) in humans and rodents [23, 24, 44].”
BackgroundSystemic growth hormone-releasing hormone (GHRH) impairs sleep in healthy young women
Mathias, S., Held, K., Ising, M., Weikel, J. C., Yassouridis, A., & Steiger, A. (2007) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2007.07.008 · Cited by 18
“After pulsatile CRH injection SWS, REMS and growth hormone (GH) are reduced, whereas cortisol is elevated (Holsboer et al., 1988).”
BackgroundSelf-citationSCHÜSSLER, P., Kluge, M., Gamringer, W., Wetter, T. C., Yassouridis, A., Uhr, M., Rupprecht, R., & Steiger, A. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.09.015 · Cited by 18
Self-citationFlumazenil exerts intrinsic activity on sleep EEG and nocturnal hormone secretion in normal controls
Steiger, A., Guldner, J., Lauer, C. J., Meschenmoser, C., Pollmächer, T., & Holsboer, F. (1994) · Psychopharmacology · doi:10.1007/bf02245206 · Cited by 18
Self-citationSafety and side effects of human and ovine corticotropin-releasing hormone administration in man
Nink, M., Krause, U., Lehnert, H., & Beyer, J. (1991) · Journal of Molecular Medicine · doi:10.1007/bf01646939 · Cited by 17
“Lower doses of hCRH repeatedly administered to healthy volunteers during sleep have a potential to alter sleep architecture [ 31 ].”
BackgroundMethodMukherjee, D., Weissenkampen, J. D., Wasserman, E. J., Krishnamurthy, V., Millett, C. E., Conway, S., & Saunders, E. F. H. (2021) · Neuropsychobiology · doi:10.1159/000517343 · Cited by 16
Endocrine and metabolic changes during sleep.
Steiger, A. (2011) · Handbook of Clinical Neurology · doi:10.1016/b978-0-444-52006-7.00016-2 · Cited by 11
“Since CRH (Holsboer et al., 1988) and cortisol exert opposite effects on SWS (Born et al., 1991; Friess et al., 1994) and GH levels (Friess et al., 1994; Bohlhalter et al., 1997), it appears unlikely that these effects are mediated via stimulation of cortisol.”
BackgroundSelf-citationHypothalamic stress systems in mood disorders
(2021) · Handbook of Clinical Neurology · doi:10.1016/b978-0-12-819973-2.00003-4 · Cited by 15
Self-citationSchmid, D. A., Brünner, H., Lauer, C. J., et al. (2008) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2007.12.003 · Cited by 15
“Since CRH injections were shown to severely disrupt sleep in humans (Holsboer et al., 1988; Born et al., 1989) and rats (Ehlers et al.”
BackgroundSelf-citationImpact of shift work on sleep and fatigue in Maritime pilots
Tait, J. L., Chambers, T. P., Tait, R. S., & Main, L. C. (2021) · Ergonomics · doi:10.1080/00140139.2021.1882705 · Cited by 16
Work stress and overtime work: Effects on cortisol, sleep, sleepiness and health
Dahlgren, A. (2006) · PsycEXTRA Dataset · doi:10.1037/e529872013-001 · Cited by 15
“An exogenous increase of CRH has been shown to result in lighter sleep with more awakenings and a decrease in deep (SWS) sleep (Holsboer et al., 1988), although this effect seems to be dependent on the level of CRH.”
Weight reduction improves sleep, sleepiness and metabolic status in obese sleep apnoea patients
Nerfeldt, P., Nilsson, B., Mayor, L., Uddén, J., Rössner, S., & Friberg, D. (2008) · Obesity Research & Clinical Practice · doi:10.1016/j.orcp.2008.08.001 · Cited by 13
Physiologie von Schlaf und Schlafregulation
Pollmächer, T., & Lauer, C. J. (1992) · Springer eBooks · doi:10.1007/978-3-642-75733-4_1 · Cited by 13
Born, J., Bathelt, B., Pietrowsky, R., et al. (1990) · Psychopharmacology · doi:10.1007/bf02253714 · Cited by 13
“The doses yielded plasma concentrations which were presumably distinctly higher than those observed under normal physiological conditions in peripheral blood, and perhaps even slightly higher than concentrations locally occurring in portal blood during stress (e.g., Gibbs and Vale 1982; Stalla et al. 1984; Suda et al.…”
BackgroundPhysiological and Pharmacological Factors of Insomnia in HIV Disease
Phillips, K. D. (1999) · Journal of the Association of Nurses in AIDS Care · doi:10.1016/s1055-3290(06)60346-4 · Cited by 13
Twenty-four hour growth hormone secretion in patients with panic disorder
Abelson, J. L., Curtis, G. C., & Uhde, T. W. (2004) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2004.02.007 · Cited by 12
Frenette, E., Lui, A., & Cao, M. T. (2012) · Vitamins and hormones · doi:10.1016/b978-0-12-394623-2.00001-9 · Cited by 12
Bretazenil modulates sleep EEG and nocturnal hormone secretion in normal men
Guldner, J., Trachsel, L., Kratschmayr, C., Rothe, B., Holsboer, F., & Steiger, A. (1995) · Psychopharmacology · doi:10.1007/bf02246085 · Cited by 12
Self-citationZhang, X.-X., Sun, S., Ma, Z.-J., Li, Z., Zhou, Y.-S., Ye, Y., Rao, J.-X., Zhang, P., Kong, X.-Y., Li, X., et al. (2024) · Sleep Medicine · doi:10.1016/j.sleep.2024.03.017 · Cited by 13
Voderholzer, U., Laakmann, G., Hinz, A., Daffner, C., Haag, C., Hofmann, H.-P., & Börschel, B. (1993) · Psychoneuroendocrinology · doi:10.1016/0306-4530(93)90012-a · Cited by 11
Kostyalik, D., Vas, S., Kátai, Z., Kitka, T., Gyertyán, I., Bagdy, G., & Tóthfalusi, L. (2014) · BMC Neuroscience · doi:10.1186/s12868-014-0120-8 · Cited by 11
“REM sleep deprivation plus chronic vehicle treatment (RD-VEH); REM sleep de also in the suppression of NREM sleep [58-60].”
MethodDie Zukunft der Depressionsforschung
Holsboer, F. (2010) · Der Nervenarzt · doi:10.1007/s00115-010-3053-1 · Cited by 11
Self-citationAssociation of job stress, CLOCK gene polymorphism and their interaction with poor sleep quality
Li, Y., Cao, Z., Wu, S., Wang, C., He, S., Dong, Y. H., & Zhang, X. (2020) · Journal of Sleep Research · doi:10.1111/jsr.13133 · Cited by 11
Dual-release hydrocortisone and its benefits on cognitive function and quality of sleep
Krekeler, C., Kropp, P., Blacha, A. K., Rahvar, A.-H., & Harbeck, B. (2021) · Endocrine · doi:10.1007/s12020-020-02552-6 · Cited by 8
Gefferie, S. R., Maric, A., Critelli, H., Guéden, S., Kurlemann, G., Kurth, S., Nosadini, M., Plecko, B., Ringli, M., Rostasy, K. M., et al. (2021) · NeuroImage · doi:10.1016/j.neuroimage.2021.118281 · Cited by 10
The hypothalamic-pituitary-adrenal (HPA) axis: A major mediator of the adaptive responses to stress
Gabry, K. E., Chrousos, G. P., & Gold, P. W. (2003) · Neuroimmune biology · doi:10.1016/s1567-7443(03)80055-8 · Cited by 12
Frieboes, R.-M., Murck, H., Antonijevic, I. A., et al. (1999) · Psychopharmacology · doi:10.1007/s002130050813 · Cited by 11
“Sleep EEG was investigated as described in detail elsewhere (Holsboer et al. 1988).”
MethodSelf-citationAmbrosio, M. R., Campo, M., Zatelli, M. C., Cella, S. G., Trasforini, G., Margutti, A., Rigamonti, A. E., Müller, E. E., & Uberti, E. C. D. (1998) · Neuroendocrinology · doi:10.1159/000054358 · Cited by 11
Rothe, N., Vogel, S., Schmelzer, K., Kirschbaum, C., Penz, M. S., Wekenborg, M., Gao, W., & Walther, A. (2021) · Comprehensive Psychoneuroendocrinology · doi:10.1016/j.cpnec.2021.100051 · Cited by 11
Wellman, L. L., Yang, L., & Sanford, L. D. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00258 · Cited by 10
“Four intravenous injections of human CRF at hourly intervals increased cortisol and reduced both REM and NREM in young healthy male volunteers (Holsboer et al., 1988).”
BackgroundDifferential effects of the stress peptides PACAP and CRF on sleep architecture in mice
Foilb, A. R., Taylor-Yeremeeva, E. M., Fritsch, E. L., Ravichandran, C. T., Lezak, K. R., Missig, G., McCullough, K. M., & Carlezon, W. A. (2024) · NPP—Digital Psychiatry and Neuroscience · doi:10.1038/s44277-024-00003-y · Cited by 8
Hormones, Cytokines, and Sleep
Obál, F., & Krueger, J. M. (2001) · Comprehensive physiology · doi:10.1002/cphy.cp070416 · Cited by 11
Atrial natriuretic hormone inhibits corticotropin-releasing hormone-induced prolactin release in man
Wiedemann, K., Herzog, L., & Kellner, M. B. (1995) · Journal of Psychiatric Research · doi:10.1016/0022-3956(94)00043-q · Cited by 10
Alpha-Helical CRH Exerts CRH Agonistic Effects on Sleep-Endocrine Activity in Humans
Held, K., Antonijevic, I. A., Murck, H., Kunzel, H. E., & Steiger, A. (2005) · Neuropsychobiology · doi:10.1159/000086606 · Cited by 9
Self-citationHolsboer, F., & Ising, M. (2024) · Pharmacopsychiatry · doi:10.1055/a-2372-3549 · Cited by 8
Self-citationPeroski, M., Proudan, N., Grignol, G., Merchenthaler, I. J., & Dudás, B. (2016) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2016.09.005 · Cited by 8
Bourjeily, G. R., & Mohsenin, V. (2009) · Humana Press eBooks · doi:10.1007/978-1-59745-445-2_4 · Cited by 8
“Furthermore, pulsatile administration of intravenous CRH to young healthy males results in a decrease of the SWS by means of an increase in cortisol secretion and blunting of GH secretion ( 43 ) .I n another study, pulsatile cortisol injections enhanced the slow wave activity on EEG spectral analysis in young normal m…”
BackgroundKalus, S., Kneib, T., Steiger, A., Holsboer, F., & Yassouridis, A. (2009) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.90530.2008 · Cited by 7
“Furthermore, many studies support the view that the neuropeptides growth hormone (GH)releasing hormone (GHRH) and corticotropin-releasing hormone (CRH) act as common regulators of sleep architecture and sleep-associated hormone release (7, 11, 17, 22).”
BackgroundSelf-citationChanges in Electroencephalographic Power Spectra Associated with Reproductive Status in Frog
Fang, G., Cui, J., Chen, Q., et al. (2011) · Lecture notes in computer science · doi:10.1007/978-3-642-21105-8_18 · Cited by 7
“Some hormones including the growth hormone, cortisol and its releasing factors, affect nocturnal sleep EEGs and have been studied thoroughly in both human and animal subjects [ 3 ],[4].”
BackgroundAdeniyi, M. J., Awosika, A., Millis, R. M., & Ige, S. F. (2023) · IntechOpen eBooks · doi:10.5772/intechopen.109148 · Cited by 10
Cauter, E. V., & Turek, F. W. (2001) · Comprehensive physiology · doi:10.1002/cphy.cp070415 · Cited by 7
Endocrine Function During Sleep and Sleep Deprivation
Mullington, J. M. (2009) · Elsevier eBooks · doi:10.1016/b978-008045046-9.00067-x · Cited by 7
Sharma, S. S., Saini, J., Chacko, S. R., Ahmadian, S., Fell, V. M., Erickson, D. Z., Peersen, A. F., Achenbach, S. J., Atkinson, E. J., & Bancos, I. (2025) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgaf553 · Cited by 7
A dopamine D1-like receptor-specific agonist improves the survival of septic mice
Tanaka, K., Choudhury, M. E., Kikuchi, S., Takeda, I., Umakoshi, K., Miyaue, N., Mikami, K., Takenaga, A., Yagi, H., Shinabe, R., et al. (2024) · iScience · doi:10.1016/j.isci.2024.109587 · Cited by 6
“47 AVP has also been implicated in sleep disturbances or insomnia.”
Hypothalamic-Pituitary-Adrenal Axis
Gabry, K. E., Gold, P. W., & Chrousos, G. P. (2002) · Elsevier eBooks · doi:10.1016/b978-012532104-4/50083-4 · Cited by 7
Metadata
- Authors
- Holsboer, F., von Bardeleben, U., & Steiger, A.
- Affiliations
- Johannes Gutenberg University Mainz (DE)
- Venue
- Neuroendocrinology
- Publisher
- S. Karger AG
- Published
- 2008-04-02
- Volume
- 48
- Issue
- 1
- Pages
- 32-38
- ISSN
- 0028-3835 (ISSN-L)
- 1423-0194
- OpenAlex
- W2040727780
- Cited by
- 255
- References
- 0
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 7 · 2023: 2 · 2022: 6 · 2021: 11 · 2020: 3 · 2019: 3 · 2018: 1 · 2017: 3 · 2016: 3 · 2015: 6 · 2014: 7 · 2013: 6 · 2012: 2
- FWCI
- 5.66
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Keywords
- corticotropin-releasing factor, cortisol secretion, sleep EEG, REM sleep, slow-wave sleep, sleep architecture, growth hormone secretion, circadian rhythm
- MeSH terms
- Adult, Corticotropin-Releasing Hormone, Electroencephalography, Humans, Injections, Intravenous, Male, Pituitary-Adrenal System, Sleep, Growth Hormone
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
