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Distribution of Estrogen Receptor-β-Like Immunoreactivity in Rat Forebrain
Abstract
The data presented here are the first to describe the distribution of estrogen receptor-β(ERβ)-like immunoreactivity in brain tissue. We employed an affinity purified rabbit antisemm made against a portion of the C-terminal of the ERβ protein. The majority of ERβ-like immunoreactive (ERβ-ir) neurons were found in the following regions: lateral septum, bed nucleus of the stria terminalis, paraventricular nucleus, supraoptic nucleus, medial amygdala, the dentate gyms and the CA1 and CA2 fields of the hippocampus. A few ERβ-ir neurons were noted in the anterior hypothalamus, periventricular nucleus, medial preoptic area, and in the arcuate nucleus. All of the immunoreactivity appeared nuclear in its subcellular distribution, with the exception of the cells in the lateral septum, CA1 and CA2. In these areas immunoreactivity was noted throughout the perikarya and in cell processes. The data suggest that ERβ mediates estrogen’s actions in a subset of hypothalamic and limbic neurons.
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Metadata
- Authors
- Li, X., Schwartz, P. E., & Rissman, E. F.
- Affiliations
- University of Virginia (US)
- Venue
- Neuroendocrinology
- Publisher
- S. Karger AG
- Published
- 2008-04-09
- Volume
- 66
- Issue
- 2
- Pages
- 63-67
- ISSN
- 0028-3835 (ISSN-L)
- 1423-0194
- OpenAlex
- W2061800243
- Cited by
- 257
- References
- 0
- Citations by year
- 2024: 1 · 2022: 3 · 2021: 2 · 2020: 1 · 2019: 3 · 2018: 2 · 2017: 2 · 2016: 4 · 2015: 2 · 2014: 1 · 2013: 5 · 2012: 2
- FWCI
- 6.27
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01ns035429-03)
- European Regional Development Fund
- National Institute of Mental Health (KO2 MH01349, K02MH001349)
- National Institute of Neurological Disorders and Stroke (R01 NS 35429)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- estrogen receptor beta, forebrain, lateral septum, bed nucleus of the stria terminalis, paraventricular nucleus, supraoptic nucleus, medial amygdala, dentate gyrus, hippocampus, hypothalamus, limbic system, subcellular localization
- MeSH terms
- Animals, Female, Immunohistochemistry, Male, Neurons, Orchiectomy, Ovariectomy, Receptors, Estrogen, Subcellular Fractions, Prosencephalon, Rats, Sprague-Dawley, Rats
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