Hepatic Clearance Measurements and Pharmacokinetics
Abstract
This review emphasizes the need for well-defined models for hepatic pharmacokinetics and discusses the interpretation of hepatic clearance measurements. Such recent approaches are subjected to theoretical and experimental comparisons. The pharmacokinetic consequences, including a classification of drugs according to hepatic clearance, are outlined.
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Organ clearance is based on the loss of a parent drug across an organ of elimination.
“The concept of organ clearance is based on the loss of a parent drug across an organ of elimination [29,30,31,32].”
From Interpretation of Non-Clinical Data for Prediction of Human Pharmacokinetic Parameters: In Vitro-In Vivo Extrapolation and Allometric Scaling (2019) · cites this paper as [32]
Typically ER decreases with increasing QH.
“Typically ER decreases with increasing QH [32].”
From Interpretation of Non-Clinical Data for Prediction of Human Pharmacokinetic Parameters: In Vitro-In Vivo Extrapolation and Allometric Scaling (2019) · cites this paper as [32]
Cited by
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Choi, G.-W., Lee, Y.-B., & Cho, H.-Y. (2019) · Pharmaceutics · doi:10.3390/pharmaceutics11040168 · Cited by 76 · see citing works
“Typically ER decreases with increasing QH [32].”
- Authors
- Keiding, S., & Buch Andreasen, P.
- Affiliations
- Rigshospitalet (DK)
- Corresponding author
- Keiding, S.
- ORCID
- Keiding, S.
- Venue
- Pharmacology
- Publisher
- S. Karger AG
- Published
- 2008-05-29
- Volume
- 19
- Issue
- 3
- Pages
- 105-110
- ISSN
- 0031-7012 (ISSN-L)
- 1423-0313
- OpenAlex
- W2009115623
- Cited by
- 23
- References
- 0
- Citations by year
- 2026: 1 · 2019: 1
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
- Keywords
- hepatic clearance
- MeSH terms
- Pharmaceutical Preparations, Humans, Kinetics, Liver, Liver Circulation, Liver Diseases, Models, Biological
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