Melatonin Decreases Brain Serotonin Release, Arterial Pressure and Heart Rate in Rats
Abstract
The effects of intravenous administration of melatonin (30–60 mg/kg) or vehicle (10% alcohol) on arterial pressure, heart rate, blood gases or brain serotonin release were assessed in rats under urethane anesthesia. Administration of melatonin, but not the vehicle, produced a dose-related fall in mean arterial pressure, heart rate, or serotonin release in both the corpus striatum and the hypothalamus. Melatonin treatment had an insignificant effect on either P a CO 2, P a O 2 or pH. In addition, the melatonin-induced depressor responses were abolished by pretreatment with spinal transection, whereas melatonin-induced bradycardia was abolished by pretreatment with bilateral vagotomy. These results suggest that melatonin decreases brain serotonin release and results in sympathetic inhibition or parasympathetic stimulation which leads to hypotension and bradycardia in rats.
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Melatonin reduces arterial blood pressure in normal and hypertensive rats.
“Melatonin has been reported to reduce arterial blood pressure in normal and hypertensive rats (Kawashima et al. 1987; Chuang et al. 1993; K-Laflamme et al. 1998).”
From Melatonin attenuates the sympathetic nerve responses to orthostatic stress in humans (2003) · cites this paper as Chuang et al. 1993
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Circadian mechanisms of 24-hour blood pressure regulation and patterning
Smolensky, M. H., Hermida, R. C., & Portaluppi, F. (2017) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2016.02.003 · Cited by 237 · see citing works
K.-Laflamme, A. (1998) · American Journal of Hypertension · doi:10.1016/s0895-7061(97)00401-9 · Cited by 97 · see citing works
Burgess, H. J., Sletten, T., Savic, N., Gilbert, S. S., & Dawson, D. (2001) · Journal of Applied Physiology · doi:10.1152/jappl.2001.91.3.1214 · Cited by 94 · see citing works
Melatonin attenuates the sympathetic nerve responses to orthostatic stress in humans
Ray, C. A. (2003) · The Journal of Physiology · doi:10.1111/j.1469-7793.2003.01043.x · Cited by 51 · see citing works
- Authors
- Chuang, J. I., Chen, S. S., & Lin, M. T.
- Affiliations
- Kaohsiung Medical University (TW)
- National Cheng Kung University (TW)
- ORCID
- Lin, Mao T.
- Venue
- Pharmacology
- Publisher
- S. Karger AG
- Published
- 2008-06-10
- Volume
- 47
- Issue
- 2
- Pages
- 91-97
- ISSN
- 0031-7012 (ISSN-L)
- 1423-0313
- OpenAlex
- W2059594432
- Cited by
- 99
- References
- 0
- Citations by year
- 2025: 3 · 2024: 2 · 2023: 3 · 2022: 3 · 2020: 2 · 2019: 5 · 2018: 4 · 2017: 1 · 2016: 3 · 2015: 3 · 2014: 3 · 2013: 2 · 2012: 2
- FWCI
- 1.33
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- melatonin, serotonin release, arterial pressure, heart rate, bradycardia, hypotension, striatum, hypothalamus, spinal cord transection, vagotomy, sympathoinhibition, parasympathetic activation, blood gases, dose-response relationship
- MeSH terms
- Animals, Blood Pressure, Brain Chemistry, Carbon Dioxide, Corpus Striatum, Heart Rate, Hypothalamus, Injections, Intravenous, Male, Melatonin, Oxygen, Serotonin, Rats, Sprague-Dawley, Rats
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