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Diagnosis of Twin Zygosity by Mailed Questionnaire
Abstract
A deterministic questionnaire method for zygosity determination is developed for use in epidemiological studies of adult twins. It is based on the answers of both members of a twin pair to two questions on similarity and confusion in childhood. The algorithm of the method is used to determine the zygosity status of a twin pair at two different levels of certainty. The validity of the method is tested by making blood marker determinations of 11 polymorphic marker systems fro a random sample of 104 twin pairs. The agreement between questionnaire and blood marker diagnosis was 100%, but the stricter level of certainty left 8.7% in the nonclassified group. The genetical representativeness of the sample is tested by the allele distribution of the markers as compared to the Finnish population data as well as by the distribution of the number of intra-pair differences in blood markers.
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Cited by
Lichtenstein, P., Holm, N. V., Verkasalo, P. K., Iliadou, A., Kaprio, J., Koskenvuo, M., Pukkala, E., Skytthe, A., & Hemminki, K. (2000) · New England Journal of Medicine · doi:10.1056/nejm200007133430201 · Cited by 4,114
Self-citationThe Twin Spine Study: Contributions to a changing view of disc degeneration†
Battié, M. C., Videman, T., Kaprio, J., Gibbons, L. E., Gill, K., Manninen, H., Saarela, J., & Peltonen, L. (2009) · The Spine Journal · doi:10.1016/j.spinee.2008.11.011 · Cited by 367
Self-citationPrevalence and heritability of compulsive hoarding: a twin study
Iervolino, A. C., Perroud, N., Fullana, M. A., Guipponi, M., Cherkas, L., Collier, D. A., & Mataix-Cols, D. (2009) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2009.08121789 · Cited by 297
Insufficient sleep—a population-based study in adults
Hublin, C., Kaprio, J., Partinen, M., & Koskenvuo, M. (2001) · Sleep · doi:10.1093/sleep/24.4.392 · Cited by 240
Self-citationKeskitalo, K., Tuorila, H., Spector, T. D., Cherkas, L. F., Knaapila, A., Kaprio, J., Silventoinen, K., & Perola, M. (2008) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/88.2.263 · Cited by 223
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Metadata
- Authors
- Sarna, S., Kaprio, J., Sistonen, P., & Koskenvuo, M.
- Venue
- Human Heredity
- Publisher
- S. Karger AG
- Published
- 1978
- Volume
- 28
- Issue
- 4
- Pages
- 241-254
- ISSN
- 0001-5652 (ISSN-L)
- 1423-0062
- OpenAlex
- W2033466565
- Cited by
- 432
- References
- 0
- FWCI
- 4.41
- Type
- journal article
- Language
- en
- Open access
- closed
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- Sarna, S., Kaprio, J., Sistonen, P., & Koskenvuo, M. (1978). Diagnosis of Twin Zygosity by Mailed Questionnaire. Human Heredity. https://doi.org/10.1159/000152964
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
