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Avoiding Recomputation in Linkage Analysis
Abstract
We describe four improvements we have implemented in a version of the genetic linkage analysis programs in the LINKAGE package: subdivision of recombination classes, better handling of loops, better coordination between the optimization and output routines, and a checkpointing facility. The unifying theme for all the improvements is to store a small amount of data to avoid expensive recomputation of known results. The subdivision of recombination classes improves on a method of Lathrop and Lalouel [Am J Hum Genet 1988;42:498-505]. The new method of handling loops extends a proposal of Lange and Elston [Hum Hered 1975;25:95-105] for loopless pedigrees with multiple nuclear families at the earliest generation. From a practical point of view, the most important improvement may be the checkpointing facility which allows the user to carry out linkage computations that are much longer than the mean-time-to-failure of the underlying computer.
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Self-citationYang, Y., Hentati, A., Deng, H.-X., Dabbagh, O., Sasaki, T., Hirano, M., Hung, W.-Y., Ouahchi, K., Yan, J., Azim, A. C., et al. (2001) · Nature Genetics · doi:10.1038/ng1001-160 · Cited by 743
Metadata
- Authors
- Schäffer, A. A., Gupta, S. K., Shriram, K., & Cottingham, Jr.
- Venue
- Human Heredity
- Publisher
- S. Karger AG
- Published
- 1994
- Volume
- 44
- Issue
- 4
- Pages
- 225-237
- ISSN
- 0001-5652 (ISSN-L)
- 1423-0062
- OpenAlex
- W2061833150
- Cited by
- 668
- References
- 0
- FWCI
- 23.28
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Avoiding Recomputation in Linkage Analysis. https://app.cochat.ai/papers/10.1159/000154222
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- Schäffer, A. A., Gupta, S. K., Shriram, K., & Cottingham, Jr. (1994). Avoiding Recomputation in Linkage Analysis. Human Heredity. https://doi.org/10.1159/000154222
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