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Cited by 186Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsNeurological Disease Mechanisms and Treatments

Mixed Brain Pathologies in Dementia: The BrainNet Europe Consortium Experience

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Kovacs, Gabor G., Alafuzoff, Irina, Al-Sarraj, Safa, Arzberger, Thomas, Bogdanovic, Nenad, Capellari, Sabina, Ferrer, Isidro, Gelpi, Ellen +8 more·2008·Dementia and Geriatric Cognitive Disorders
DOI 10.1159/000161560
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Abstract

Background: Dementia results from heterogeneous diseases of the brain. Mixed disease forms are increasingly recognized. Methods: We performed a survey within brain banks of BrainNet Europe to estimate the proportion of mixed disease forms underlying dementia and age- and gender-specific influences. Results: Data collected in 9 centres from 3,303 individuals were analysed. The proportion of patients with mixed diagnoses among all cases with Alzheimer disease (AD), vascular pathology (VP), argyrophilic grain dementia (AGD), and synucleinopathies, such as Lewy body dementia (LBD), Parkinson disease (PD) and synuclein pathology only in the amygdala, was 53.3%. Mixed pathology was more frequently reported with LBD, PD, AGD, and VP than with AD. The percentage of mixed diagnoses for AGD and VP significantly differed between centres. In patients younger than 75 years, synucleinopathies, and pure forms of AD, VP, and AGD were more frequent in men. Above 75 years of age, more women had pure AD and pure AGD. Conclusions: The most obvious neuropathological alteration should not terminate the diagnostic procedure since copathology is likely to be found. Neuropathological interpretation of AGD and VP has not been sufficiently established in a consensus. Pure forms of synucleinopathies are unlikely sole substrates for dementia.

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  • Common age-related neuropathologies, including Alzheimer's disease and other neurodegenerative and cerebrovascular pathologies, are the main causes of dementia, including Alzheimer's dementia.

    “Common age-related neuropathologies, including Alzheimer’s disease (AD) and other neurodegenerative and cerebrovascular pathologies, are the main causes of dementia, including Alzheimer’s dementia [31,34].”

    From Sex differences in Alzheimer’s disease and common neuropathologies of aging (2018) · cites this paper as [34]

    The Introduction says neurodegenerative diseases are the most common disorders underlying dementia, and the Results document AD, vascular pathology, and other diagnoses among people with dementia. The Influence of Age and Gender section reports that AD and combined diagnoses were more frequent in older patients. The paper does not establish that cerebrovascular pathology is among the main causes, or specifically assess the causes of clinically diagnosed Alzheimer’s dementia. (LLM, conf=0.83)

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  • Another study reported that an AD pathologic diagnosis was more common among women in patients older than age 75 years.

    “Further, another study reported that an AD pathologic diagnosis was more common among women in patients older than age 75 years [34].”

    From Sex differences in Alzheimer’s disease and common neuropathologies of aging (2018) · cites this paper as [34]

  • Two studies that reported different sex-AD pathology association in different ages did not utilize statistical interaction modeling.

    “Likewise, two studies that reported different sex-AD pathology association in different ages did not utilize statistical interaction modeling [34,43].”

    From Sex differences in Alzheimer’s disease and common neuropathologies of aging (2018) · cites this paper as [34]

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Authors
Kovacs, G. G., Alafuzoff, I., Al-Sarraj, S., Arzberger, T., Bogdanovic, N., Capellari, S., Ferrer, I., Gelpi, E., Kövari, V., Kretzschmar, H., Nagy, Z., Parchi, P., Seilhean, D., Soininen, H., Troakes, C., & Budka, H.
Affiliations
  • University of Eastern Finland (FI)
  • Institut für Neuropathologie (DE)
  • Istituto delle Scienze Neurologiche di Bologna (IT)
  • Assistance Publique – Hôpitaux de Paris (FR)
  • King's College London (GB)
  • St Anna Children's Hospital (AT)
ORCID
Venue
Dementia and Geriatric Cognitive Disorders
Publisher
S. Karger AG
Published
2008
Volume
26
Issue
4
Pages
343-350
ISSN
  • 1420-8008 (ISSN-L)
  • 1421-9824
DOI
10.1159/000161560
OpenAlex
W2101841732
Cited by
186
References
35
Citations by year
2026: 7 · 2025: 14 · 2024: 10 · 2023: 6 · 2022: 12 · 2021: 9 · 2020: 11 · 2019: 10 · 2018: 9 · 2017: 13 · 2016: 12 · 2015: 10 · 2014: 16 · 2013: 9 · 2012: 15
FWCI
5.39
Type
journal article
Language
en
Open access
Licence
Locations
  • Dementia and Geriatric Cognitive Disorders (publishedVersion)
  • PubMed (publishedVersion)
  • Open access LMU (Ludwid Maxmilian's Universitat Munchen) (submittedVersion)
  • Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
Keywords
dementia, Alzheimer's disease, vascular pathology, synucleinopathies, dementia with Lewy bodies, Parkinson's disease, brain banks, neuropathology, sex differences, age differences
MeSH terms
Age Factors, Aged, Aged, 80 and over, Brain, Dementia, Europe, Female, Humans, Male, Middle Aged, Sex Factors, Tissue Banks

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